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| 1 | ERK kinase phosphorylates and destabilizes the tumor suppressor FBW7 in pancreatic cancer显示文摘 | Shunrong Ji Yi Qin Si Shi Xiangyuan Liu Hongli HU Hu Zhou Jing Gao Bo Zhang Wenyan Xu Jiang Liu Dingkong Liang Liang Liu Chen Liu Jiang Long Haijun Zhou Paul J Chiao Jin Xu Quanxing Ni Daming Gao Xianjun Yu | 2015 | Cell Research2015，25，5： | 19 |
| 2 | Outcomes of furazolidone-and amoxicillin-based quadruple therapy for Helicobacter pylori infection and predictors of failed eradication显示文摘AIM To evaluate the outcomes of furazolidone-and amoxicillin-based quadruple therapy for treatment of Helicobacter pylori(H. pylori) infection and identify predictors of failed eradication.METHODS Patients with H. pylori infection treated with furazolidone, amoxicillin, bismuth, and proton pump inhibitor therapy(January 2015 to December 2015) who received the ^(13)C-urea breath test > 4 wk after treatment were evaluated. Demographic and clinical data including prior H. pylori treatment attempts, medication adherence, alcohol and cigarette consumption during therapy, and treatment-related adverse events were recorded by reviewing medical records and telephone surveys. H. pylori eradication rates for overall and subgroups were evaluated. Multivariate analysis was performed to identify independent predictors of failed H. pylori eradication.RESULTS Of the 992 patients treated and retested for H. pylori infection, the overall eradication rate was 94.5% [95% confidence interval(CI): 94.1%-95.9%]. H. pylori eradication rate of primary therapy was 95.0%(95%CI: 93.5%-96.5%), while that of rescue therapy was 91.3%(95%CI: 86.8%-95.8%). Among the 859 patients who completed the study protocol, 144(17%) reported treatment-related adverse events including 24(3%) leading to premature discontinuation. On multivariate analysis, poor medication adherence [adjusted odds ratio(AOR) = 6.7, 95%CI: 2.8-15.8], two or more previous H. pylori treatments(AOR = 7.4, 95%CI: 2.2-24.9), alcohol consumption during therapy(AOR = 4.4, 95%CI: 1.5-12.3), and possibly smoking during therapy(AOR = 1.9, 95%CI: 0.9-4.3) were associated with failed H. pylori eradication. CONCLUSION Furazolidone-and amoxicillin-based quadruple therapy for H. pylori infection in an area with a high prevalence of clarithromycin resistance demonstrated high eradication rates as primary and rescue therapies with a favorable safety profile. Patient education targeting abstinence from alcohol during therapy and strict medication adherence may further optimize H. pylori eradication. | Ya-Wen Zhang Wei-Ling Hu Yuan Cai Wen-Fang Zheng Qin Du John J Kim John Y Kao Ning Dai Jian-Min Si | 2018 | World Journal of Gastroenterology2018，24，40： | 18 |
| 3 | Effect of dispersant concentration on slip casting of cordierite-based glass ceramics 显示文摘 | MEI Si YANG J FERREIRA M F | 2001 | J Colloid Interface Sci2001，241，： | 2 |
| 4 | Age-dependent reductions in the level of glial fibrillary acidic protein in the prefrontal cortex in major depression显示文摘 | Si X Miguel-Hidalgo J J O′Dwyer G | 2004 | Neuropsychopharmacology2004，29，： | 1 |
| 5 | Global exponential stability of neural networks with globally Lipschitz continuous activations and its application to linear variational inequality problem显示文摘 | Liang X B Si J | 2001 | IEEE Trans Neural Networks2001，12，2： | 1 |
| 6 | Osmotic tolerance limitsand effects of cryoprotectants on the motility,plasma mem-brane integrity and acrosomal integrity of rat sperm显示文摘 | SI W BENSON J D MEN H | 2006 | Cryo-biology2006，53，3： | 1 |
| 7 | Nitrogen, sulfur, and chlorine trans- formations during the pyrolysis of straw显示文摘 | Wang X B Si J P Tan H Z | 2010 | Energy & Fuels2010，24，9： | 1 |
| 8 | Struma ovarii: CT findings显示文摘 | Jung SI Kim Y J Lee MW | 2008 | Abdom Imaging2008，33，6： | 1 |
| 9 | RP-LC simultaneous de- termination of nebivolol hydrochloride and amlodipine be- silate in bi-layer tablets显示文摘 | Joshi S J Karbhari PA Bhoir SI | 2009 | Chromatographia2009，70，34： | 1 |
| 10 | Surgical Resection of Esopha- geal Gastrointestinal Stromal Tumors 显示文摘 | Lee H J Park SI Kim DK | 2009 | Ann Thorac Surg2009，87，5： | 1 |
| 11 | Holocene climate changes in the monsoon/arid transition reflected by carbon concentration in Daihai Lake of Inner Mongolia显示文摘 | XIAOJ L WU J T SI B | | 0，，04： | 1 |
| 12 | Dye Congo Red adsorptive decolorization by adsorbents obtained fi'om Trametes pubescer pellets显示文摘 | Si J Cui B K | 2013 | Desalination and Water Treatment2013，51，： | 1 |
| 13 | Complete genome sequencing and analysis of six entemvirus 71 strains with different clinical phe- notypes显示文摘 | Wen HL Si LY Yuan X J | 2013 | Virol J2013，10，： | 1 |
| 14 | Innate signaling by the C-type lectin DC-SIGN dictates immune responses 显示文摘 | den Dunnen J Gringhuis SI Geijtenbeek TB | 2009 | Cancer Immunol Immunother2009，58，7： | 1 |
| 15 | Hematogenous spreading of hepatocellular careinoma cells:possible participation in recurrence in the liver显示文摘 | Funaki NO Tanaka J Seto SI | 1997 | Hepatology1997，25，5： | 1 |
| 16 | Pathogen recognition by DC-SIGN shapes adaptive immunity显示文摘 | Geijtenbeek TB den Dunnen J Gringhuis SI | 2009 | Future microbiology2009，4，： | 1 |
| 17 | The Relational View:Cooperative Strategy and Sources of Interorganizational Competitive Advantage显示文摘 | DYER J H SI NGH H | 1998 | Academy of Management Review1998，，： | 1 |
| 18 | The cytokines IL-3 and GM CSF regulate the transcriptional activity of retinoic acid receptors in different in vitro models of myeloid differentiation 显示文摘 | Johnson BS Mueller L Si J | 2002 | Blood2002，99，3： | 1 |
| 19 | Biomechanical study of odontoid fractures and fracture fixation显示文摘 | BRAIN J DOHERTY MH HEGGENESS SI | 1993 | Spine1993，18，： | 1 |
| 20 | Mechanisms of resistance to5-aza-2′-deoxycytidine in human cancer cell lines显示文摘 | Qin T Jelinek J Si J | 2009 | Blood2009，113，3： | 1 |
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