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| 1 | Quercetin protects human brain microvascular endothelial cells from fibrillarβ-amyloid_(1–40)-induced toxicity显示文摘Amyloid beta-peptides(Aβ) are known to undergo active transport across the blood-brain barrier, and cerebral amyloid angiopathy has been shown to be a prominent feature in the majority of Alzheimer's disease. Quercetin is a natural flavonoid molecule and has been demonstrated to have potent neuroprotective effects, but its protective effect on endothelial cells under Aβ-damaged condition is unclear. In the present study, the protective effects of quercetin on brain microvascular endothelial cells injured by fibrillar Aβ_(1–40)(f Aβ_(1–40)) were observed. The results show that f Aβ_(1–40)-induced cytotoxicity in human brain microvascular endothelial cells(h BMECs) can be relieved by quercetin treatment. Quercetin increases cell viability, reduces the release of lactate dehydrogenase, and relieves nuclear condensation.Quercetin also alleviates intracellular reactive oxygen species generation and increases superoxide dismutase activity. Moreover, it strengthens the barrier integrity through the preservation of the transendothelial electrical resistance value, the relief of aggravated permeability, and the increase of characteristic enzyme levels after being exposed to f Aβ_(1–40). In conclusion, quercetin protects h BMECs from f Aβ_(1–40)-induced toxicity. | Yongjie Li Sibai Zhou Jinze Li Yuhua Sun Hamlati Hasimu Rui Liu Tiantai Zhang | 2015 | Acta Pharmaceutica Sinica B2015，5，1： | 3 |
| 2 | Diabolical points in coupled active cavities with quantum emitters显示文摘In single microdisks,embedded active emitters intrinsically affect the cavity modes of the microdisks,resulting in trivial symmetric backscattering and low controllability.Here we demonstrate macroscopic control of the backscattering direction by optimizing the cavity size.The signature of the positive and negative backscattering directions in each single microdisk is confirmed with two strongly coupled microdisks.Furthermore,diabolical points are achieved at the resonance of the two microdisks,which agrees well with theoretical calculations considering the backscattering directions.Diabolical points in active optical structures pave the way for an implementation of quantum information processing with geometric phase in quantum photonic networks. | Jingnan Yang Chenjiang Qian Xin Xie Kai Peng Shiyao Wu Feilong Song Sibai Sun Jianchen Dang Yang Yu Shushu Shi Jiongji He Matthew JSteer Iain GThayne Bei-Bei Li Fang Bo Yun-Feng Xiao Zhanchun Zuo Kuijuan Jin Changzhi Gu Xiulai Xu | 2020 | Light(Science & Applications)2020，9，1： | 2 |
| 3 | Observation of coupling between zero- and two- dimensional semiconductor systems based on anomalous diamagnetic effects显示文摘我们报导在一个单个自我装配的 InAs 量点和弄湿的层之间联合的直接观察,基于用磁电机光致发光光谱学的许多身体激子状态的强壮的抗磁的移动。当在弄湿的层的一个电子在量点与一个洞结合时,一个极其大的积极抗磁的系数被观察;系数比在量点限制的激子状态的大将近一个数量级。有在联合系统的一个量点的洞的电子的再结合导致不平常的否定抗磁的效果,它在一个纯量点系统是比那强壮五倍的。这效果能被归因于在再结合以后处于量点的激动的状态在弄湿的层或电子的传播仍然是电子到弄湿的层的 wavefunction 的扩大。在这种情况中,因为洞的缺席,在量点飞机的最后的状态的 wavefunction 程度比起始的状态的大得多吸引电子。在弄湿的层取决于大电子 wavefunction 程度的射出的光子的性质显示联合发生在不同维数的系统之间,它也从在不同配置使用一个磁场获得的结果被验证。这研究铺平一条新道路与零维、二维的结构观察混合状态,它能为调查 Kondo 物理并且实现是有用的基于纺纱固态量信息处理。 | Shuo Cao Jing Tang Yue Sun Kai Peng Yunan Gao Yanhui Zhao Chenjiang Qian Sibai Sun Hassan Ali Yuting Shao Shiyao Wu Feilong Song David A. Williams Weidong Sheng Kuijuan Jin Xiulai Xu | 2016 | Nano Research2016，9，2： | 2 |
| 4 | Association of H . pylori Infection with Insulin Resistance and Metabolic Syndrome Among L ebanese Adults显示文摘 | Farah Naja Lara Nasreddine Nahla Hwalla Patricia Moghames Hikma Shoaib Maamoun Fatfat Abla Sibai Hala Gali‐Muhtasib | 2012 | Helicobacter2012，，6： | 2 |
| 5 | Pre-eclampsia显示文摘 | Sibai B Dekker G Kupferminc M | 2005 | Lancet2005，365，9461： | 1 |
| 6 | Pre-eclampsia显示文摘 | Sibai B Dekker G Kupferminc M | 2005 | Lancet2005，36，5： | 1 |
| 7 | Diagnosis, controversies,and management of the syndrome of hemolysis, elevated liver enzymes, and low platelet count显示文摘 | SIBAI B M | 2004 | Obstet Gynecol2004，103，： | 1 |
| 8 | Management of late preterm and early-term pregnancies complicated by mild gestational hypertension /pre-eclampsia显示文摘 | Sibai BM | 2011 | Semin perinatol2011，35，： | 1 |
| 9 | Diagnosis and management of gestational hypertension and preeclampsia Obstet Gynecol显示文摘 | Sibai BM | 2003 | 102(1): 181 - 1872003，102，1： | 1 |
| 10 | Acute renal failure in hypertensive disorders of pregnancy显示文摘 | Sibai B M Villar M A Mabie B C | 1990 | Am J Obstet Gyneco11990，162，： | 1 |
| 11 | Current obstetrieal practice and umbilical cord prolapse显示文摘 | Usta IM MercerBM Sibai BM | 1999 | Am J Perination1999，16，9： | 1 |
| 12 | Spontaneously Conceived Pregnancy after 40: Influence of Age and Obesity on Outcome显示文摘 | John Barton Amanda Sibai Niki Istwan Debbie Rhea Cheryl Desch Baha Sibai | 2013 | Amer J Perinatol2013，，： | 1 |
| 13 | Cutaneous uretero-ureterostomy:a technique of urinary diversion for high-risk patients with bladder cancer显示文摘 | Shafik A Shafik I A El Sibai O | 2007 | Surg Technol Int2007，16，： | 1 |
| 14 | Iris recognition using artificial neural networks 显示文摘 | SIBAI F HOSANI H NAQBI R | 2011 | Expert Systems with Applications2011，38，5： | 1 |
| 15 | HELLP syndrome显示文摘 | Egerman RS Sibai BM | 1999 | Clin Obstet Gynecol1999，42，： | 1 |
| 16 | A protocol for managing severe preeclampsia in the second trimester显示文摘 | Sibai BM Akl S Fairlie F | 1990 | Am J Obstet Gynecol1990，163，3： | 1 |
| 17 | Diagnosis,prevention,and management of eclampsia显示文摘 | Sibai BM | | 0，，： | 1 |
| 18 | Chronic hypertension in pregnancy显示文摘 | Sibai BM | 2002 | Obstet Gynecol2002，100，： | 1 |
| 19 | Diagnosis and management of gestational hypertension and preeclampsia 显示文摘 | Sibai BM | 2003 | Obstet Gyneeol2003，102，1： | 1 |
| 20 | Diagnosis,Controversies,and Management of the Syndrome of Hemolysis,Elevated Liver Enzymes,and Low Platelet Count显示文摘 | Sibai BM | | 0，，5： | 1 |
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