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| 1 | Diverse modes of clonal evolution in HBV-related hepatocellular carcinoma revealed by single-cell genome sequencing显示文摘Hepatocellular 癌(HCC ) 是癌症实质词法,基因并且 phenotypic 差异。然而,我们不理解在 intratumor 异质和肿瘤的联系词法 / 组织学的特征之间的关系。用介绍 96 个肿瘤房间(30-36 各个) 和 15 个正常的肝房间(5 各个) 的单个房间的整个染色体的定序,与联系 HBV 的 HCC 从三个男病人收集了,我们证实拷贝数字变化在 hepatocarcinogenesis 早发生,但是此后在整个肿瘤仍然保持相对稳定前进。重要地,我们证明特定的 HCC 能具有 monoclonal 或 polyclonal 起源。有汇合的 multinodular 形态学的肿瘤是典型 polyclonal 肿瘤并且显示最高的 intratumor 异质。除了 mutational 和拷贝数字侧面,我们把了用导出 HBV 的外国 genomic 标记的 HCC 的同种细胞的起源。在 monoclonal HCC,所有肿瘤单身者房间展出一样的 HBV 集成,显示 HBV 集成是一个早司机事件并且在肿瘤前进期间仍然保持极其稳定。另外,我们的结果显示那两个都转移,迟了的传播并且早播种当模特儿,在 HCC 有一个角色前进。尤其是,开始的克隆传播的早 intrahepatic 导致同步 multifocal 肿瘤的形成。同时,我们在 HCC 识别了潜在的司机基因 ZNF717,它展出变化的高频率在单个房间并且人口铺平,,通过调整 IL-6/STAT3 小径行动的肿瘤 suppressor。这些调查结果热点多重不同肿瘤在 HCC 的进化机制,它为特定的处理策略建议需要。 | Meng Duan, Shu Zhang, Zhichao Wang, Jieyi Shi, Longzi Liu, Xiaoying Wang, Aiwu Ke, Jian Zhou, Jia Fan, Qiang Gao Junfeng Hao, Chong Li Sijia Cui Daniel L Worthley Ya Cao Ruibin Xi Xiaoming Zhang Jian Zhou, Jia Fan Qiang Gao | 2018 | Cell Research2018，28，3： | 21 |
| 2 | Cyanoethyl cellulose-based eutectogel electrolyte enabling high-voltage-tolerant and ion-conductive solid-state lithium metal batteries显示文摘Solid-state polymer electrolytes are an important factor in the deployment of highsafety and high-energy-density solid-state lithium metal batteries.Nevertheless,use of the traditional polyethylene oxide-based solid-state polymer electrolyte is limited due to its inherently low ionic conductivity and narrow electrochemical stability window.Herein,for the first time,we specifically designed a cyanoethyl cellulosein-deep eutectic solvent composite eutectogel as a promising candidate for hybrid solid-state polymer electrolytes.It is found that the proposed eutectogel electrolyte achieves high ionic conductivity(1.87×10^(−3) S cm^(−1) at 25℃),superior electrochemical stability(up to 4.8 V),and outstanding lithium plating/striping behavior(low overpotential of 0.04 V at 1mAcm^(−2) and 1mAh cm^(−2) over 300 h).With the eutectogel-based solid-state polymer electrolyte,a 4.45 V LiCoO_(2)/Li metal battery delivers prominent long-term lifespan(capacity retention of 85%after 200 cycles)and high average Coulombic efficiency(99.5%)under ambient conditions,significantly outperforming the traditional carbonate-based liquid electrolyte.Our work demonstrates a promising strategy for designing eutectogel-based solid-state polymer electrolytes to realize high-voltage and high-energy lithium metal batteries. | Hao Zhang Lixue Zhou Xiaofan Du Jianjun Zhang Songwei Tian Tingting Liu Jinning Zhang Sijia Hu Weiling Song Xinhong Zhou Guanglei Cui | 2022 | Carbon Energy2022，4，6： | 3 |
| 3 | Characterization of Electric Field Distribution Within High Voltage Press-packed IGBT Submodules Under Conditions of Repetitive Turn-on and Turn-off显示文摘The high-voltage high-power press-packed IGBT(PPI)devices are the key component of the DC transmission apparatus.A PPI device is composed of several PPI submodules.In general,the PPI submodule works in a state of repetitive turn-on and turn-off,and the corresponding working voltage is the positive periodic square waveform(PPSW)voltage,which is much different from the conventional AC or DC voltage.In addition,insulation capability is one of the most critical challenges in the design and fabrication of PPI devices.To improve the insulation capability of the device,composite insulation structures with multiple dielectrics are usually employed.Under the PPSW voltage,it is essential to analyze the transient electric field to solve the insulation challenge of the PPI devices.However,the electric field of the PPI is often calculated under the electrostatic field or DC field.Moreover,the transient characteristics of the electric field are ignored.Therefore,this paper focuses on the analysis of the transient characteristics of the electric field of the PPI submodule under the PPSW voltage.The influences of the waveform parameters of the PPSW voltage on the transient characteristics are demonstrated in detail.This study is significant for the insulation analysis and design of the PPIs. | Teng Wen Xiang Cui Sijia Liu Xuebao Li Zhibin Zhao | 2022 | CSEE Journal of Power and Energy Systems2022，8，2： | 3 |
| 4 | Osteogenesis effects of magnetic nanoparticles modified-porous scaffolds for the reconstruction of bone defect after bone tumor resection显示文摘The treatment of bone defect after bone tumor resection is a great challenge for orthopedic surgeons.It should consider that not only to inhibit tumor growth and recurrence,but also to repair the defect and preserve the limb function.Hence,it is necessary to find an ideal functional biomaterial that can repair bone defects and inactivate tumor.Magnetic nanoparticles(MNPs)have its unique advantages to achieve targeted hyperthermia to avoid damage to surrounding normal tissues and promote osteoblastic activity and bone formation.Based on the previous stage,we successfully prepared hydroxyapatite(HAP)composite poly(lactic-co-glycolic acid)(PLGA)scaffolds and verified its good osteogenic properties,in this study,we produced an HAP composite PLGA scaffolds modified with MNPs.The composite scaffold showed appropriate porosity and mechanical characteristics,while MNPs possessed excellent magnetic and thermal properties.The cytological assay indicated that the MNPs have antitumor ability and the composite scaffold possessed good biocompatibility.In vivo bone defect repair experiment revealed that the composite scaffold had good osteogenic capacity.Hence,we could demonstrate that the composite scaffolds have a good effect in bone repair,which could provide a potential approach for repairing bone defect after bone tumor excision. | Ming Li Jianheng Liu Xiang Cui Guofei Sun Jianwei Hu Sijia Xu Fei Yang Licheng Zhang XiumeiWang Peifu Tang | 2019 | Regenerative Biomaterials2019，6，6： | 3 |
| 5 | Transient electric field of the combined insulation structure under positive periodic square waveform voltage:Analytical analysis and application显示文摘The working voltage of the high-voltage high-power electronic devices is the positive periodic square waveform(PPSW)voltage,which is much different from the conventional AC or DC voltage.For the composite insulation structure of devices,it is important to analyse the transient electric field under the PPSW voltage.However,the existing investigations are often conducted under the electrostatic field due to the high frequency of the PPSW voltage.Thus,the transient characteristics of the electric field are missed.To obtain some qualitative conclusions,this paper focusses on the theoretical analysis of the transient characteristics of electric field for the composite insulation structure under the PPSW voltage.First,the formula of the electric field intensity and the interfacial charge density are derived analytically.Second,the influence of the cycle and the duty cycle on the transient characteristics are investigated.Third,the maximum of the electric field intensity and the interfacial charge density in the positive square waveform steady-state are discussed in detail.Besides,the engineering calculation methods for obtaining these maximum values are also suggested.Lastly,an actual model is employed to testify the validity of the analytical analysis.This work is significant for the numerical calculation of the transient electric field of composite insulation structure under the PPSW voltage in engineering. | Teng Wen Xiang Cui Xuebao Li Sijia Liu Zhibin Zhao | 2022 | High Voltage2022，7，5： | 2 |
| 6 | PsyMuKB: An Integrative De Novo Variant Knowledge Base for Developmental Disorders显示文摘De novo variants(DNVs)are one of the most significant contributors to severe earlyonset genetic disorders such as autism spectrum disorder,intellectual disability,and other developmental and neuropsychiatric(DNP)disorders.Presently,a plethora of DNVs have been identified using next-generation sequencing,and many efforts have been made to understand their impact at the gene level.However,there has been little exploration of the effects at the isoform level.The brain contains a high level of alternative splicing and regulation,and exhibits a more divergent splicing program than other tissues.Therefore,it is crucial to explore variants at the transcriptional regulation level to better interpret the mechanisms underlying DNP disorders.To facilitate a better usage and improve the isoform-level interpretation of variants,we developed NeuroPsychiatric Mutation Knowledge Base(PsyMuKB).It contains a comprehensive,carefully curated list of DNVs with transcriptional and translational annotations to enable identification of isoformspecific mutations.PsyMuKB allows a flexible search of genes or variants and provides both table-based descriptions and associated visualizations,such as expression,transcript genomic structures,protein interactions,and the mutation sites mapped on the protein structures.It also provides an easy-to-use web interface,allowing users to rapidly visualize the locations and characteristics of mutations and the expression patterns of the impacted genes and isoforms.PsyMuKB thus constitutes a valuable resource for identifying tissue-specific DNVs for further functional studies of related disorders.PsyMuKB is freely accessible at http://psymukb.net. | Guan Ning Lin Sijia Guo Xian Tan Weidi Wang Wei Qian Weichen Song Jingru Wang Shunying Yu Zhen Wang Donghong Cui Han Wang | 2019 | Genomics, Proteomics & Bioinformatics2019，17，4： | 2 |
| 7 | Finite Element Method for Transient Electric Field by Using Indirect Laplace Transform with High Accuracy显示文摘This paper focuses on the finite element method in the complex frequency domain(CFD-FEM)for the transient electric field.First,the initial value and boundary value problem of the transient electric field under the electroquasistatic field in the complex frequency domain is given.In addition,the finite element equation and the constrained electric field equation on the boundary are derived.Secondly,the indirect algorithm of the numerical inverse Laplace transform is introduced.Based on it,the calculation procedures of the CFD-FEM are illustrated in detail.Thirdly,the step response,zero-state response under the positive periodic square waveform(PPSW)voltage,and the zero-input response by the CFD-FEM with direct algorithm and indirect algorithm are compared.Finally,the reason for the numerical oscillations of the zero-state response under the PPSW voltage is analyzed,and the method to reduce oscillations is proposed.The results show that the numerical accuracy of the indirect algorithm of the CFD-FEM is more than an order of magnitude higher than that of the direct algorithm when calculating the step response of the transient electric field.The proposed method can significantly reduce the numerical oscillations of the zero-state response under the PPSW voltage.The proposed method is helpful for the calculation of the transient electric field,especially in the case of frequency-dependent parameters. | Teng Wen Xiang Cui Xuebao Li Sijia Liu Zhibin Zhao | 2024 | CSEE Journal of Power and Energy Systems2024，10，1： | 0 |
| 8 | Low-cost fabrication of highly dispersed atomically-thin MoS2 nanosheets with abundant active Mo-terminated edges显示文摘In this work,highly dispersed atomically-thin MoS2 nanosheets were fabricated at one thousandth of the commercial cost using sepiolite(SEP)mineral nanofibers as carriers via a microwave hydrothermal method.Atomresolved microscopy revealed the MoS2 nanosheets were only 1–4 atomic layers thick.The Mo atoms anchored on the mineral surface served as nucleation sites for the nanosheet growth.The MoS2 layers were in staggered stacking yielding abundant atomic steps at the nanosheets’edges,where catalytically active molybdenum terminations dominated instead of the inert sulfur atoms commonly reported.DFT calculations disclosed that the bonding of Mo(MoS2)and O(SEP)at the MoS2/sepiolite(MSEP)interface enabled SEP to be a unique support,superior to the other minerals for growing such highly-dispersed ultrathin MoS2 architecture.In a typical photocatalyisis application,the MSEP demonstrated a significantly improved photocatalytic performance for RhB degradation compared with the MoS2 nanosheets assembled microspheres.This work provides an important new strategy for low-cost batch preparation of high quality 2D materials via assembly on mineral materials. | Fei Wang Ming Hao Wei Liu Penji Yan Baizeng Fang Sijia Li Jinsheng Liang Maomao Zhu Li Cui | 2021 | Nano Materials Science2021，3，3： | 0 |
| 9 | Seislet transform denoising based on total variation minimization显示文摘Attenuation of noise is a persistent problem in seismic exploration. The authors use conventional denoising method to remove noise which may cause vibration near the discontinuity called pseudo-Gibbs artifact.In order to remove the artifact,the study proposed a method combining the seislet transform and total variation minimization. Firstly,the data are converted into the seislet transform domain. Secondly,the hard threshold was used for eliminating the noise and keep useful signal,which is the initial input for the next step. Finally,total variation minimization dealed with denoised data to recover boundary information and further eliminated the noise. Synthetic data examples show that the method has feasibility in eliminating random noise and protecting detailed signal,and also shows better results than the classic f-x deconvolution. The field data example also shows effective in practice. It can remove the noise and preserve the discontinuity signal at the same time. | ZHANG Peng LIU Yang LIU Cai CUI Fangzi YANG Xueting PEI Sijia | 2015 | Global Geology2015，18，1： | 0 |
| 10 | Stereoselective metabolic disruption of cypermethrin by remolding gut homeostasis in rat显示文摘Cypermethrin(CYP), a prototypical synthetic pyrethroid, reportedly causes metabolic disruption, while its stereoselective impact remains elusive. This study initially revealed that only α-CYP caused significant weight loss at 8.5 mg/(kg·day) in rats. All three CYP isomers caused the accumulation of hepatic glycogen, and hyperlipemia phenotype as the increment of total triglyceride. Rats treated with α-CYP had markedly high blood glucose levels and homeostasis model assessment of insulin resistance index. The systematic inflammation of θ-CYP group rats was evidenced by high lipopolysaccharide-binding protein levels and abnormalities of leukocytes indices. By examining the gut microbiome, we found thatα-CYP-treated rats had low contents of Firmicutes and high levels of Verrucomicrobia while Elusimicrobia was enriched in the β-CYP group. The increasing alpha diversity in the θ-CYP group may be due to the dominance of pathogenic bacteria and the increase of probiotics to counteract adverse effects. Exclusively, the α-CYP group enriched total short-chain fatty acids(SCFAs), whereas most SCFAs depleted in the θ-CYP group. The correlation analysis further found Firmicutes, an energy storage modulator, was positive to body weight(BW),while SCFAs exerted the opposite, confirming the low BW in α-CYP. Blood glucose that correlated well with SCFAs and Verrucomicrobia can be accounted for the discrepancy betweenα-CYP and θ-CYP. Overall, the three isomers exerted stereoselective glycolipid disruption in rats, and gut homeostasis acted as vital indicators. | Quan Zhang Sijia Gu YanWang Shitao Hu Siqing Yue Cui Wang | 2023 | Journal of Environmental Sciences2023，，4： | 0 |
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