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| 1 | Genome-wide variants of Eurasian facial shape differentiation and a prospective model of DNA based face prediction显示文摘It is a long-standing question as to which genes define the characteristic facial features among different ethnic groups. In this study, we use Uyghurs, an ancient admixed population to query the genetic bases why Europeans and Han Chinese look different. Facial traits were analyzed based on high-dense 3D facial images; numerous biometric spaces were examined for divergent facial features between European and Han Chinese, ranging from inter-landmark distances to dense shape geometrics. Genome-wide association studies(GWAS) were conducted on a discovery panel of Uyghurs. Six significant loci were identified, four of which, rs1868752, rs118078182, rs60159418 at or near UBASH3B, COL23A1, PCDH7 and rs17868256 were replicated in independent cohorts of Uyghurs or Southern Han Chinese. A prospective model was also developed to predict 3D faces based on top GWAS signals and tested in hypothetic forensic scenarios. | Lu Qiao Yajun Yang Pengcheng Fu Sile Hu Hang Zhou Shouneng Peng Jingze Tan Yan Lu Haiyi Lou Dongsheng Lu Sijie Wu Jing Guo Li Jin Yaqun Guan Sijia Wang Shuhua Xu Kun Tang | 2018 | Journal of Genetics and Genomics2018，45，8： | 7 |
| 2 | A draft sequence of the rice (Oryza sativa ssp. indica) genome显示文摘The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a 'whole genome shotgun' approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package | YU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, GAO Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG HuanmingBeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China National Hybrid Rice R & D Center, Changsha 410125, China Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, Peking University, Beijing 100871, China Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 1Q0080, China Digital China Ltd., Beijing 100080, China Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China Medical College, Xi’an Jiaotong University, Xi’an 710061, ChinaThese authors contributed equally to this work.Corresponding author.Corresponden | 2001 | Chinese Science Bulletin2001，46，23： | 6 |
| 3 | Boosting Lean Electrolyte Lithium-Sulfur Battery Performance with Transition Metals: A Comprehensive Review显示文摘Lithium–sulfur(Li–S) batteries have received widespread attention, and lean electrolyte Li–S batteries have attracted additional interest because of their higher energy densities. This review systematically analyzes the effect of the electrolyte-to-sulfur(E/S) ratios on battery energy density and the challenges for sulfur reduction reactions(SRR) under lean electrolyte conditions. Accordingly, we review the use of various polar transition metal sulfur hosts as corresponding solutions to facilitate SRR kinetics at low E/S ratios(< 10 μL mg~(-1)), and the strengths and limitations of different transition metal compounds are presented and discussed from a fundamental perspective. Subsequently, three promising strategies for sulfur hosts that act as anchors and catalysts are proposed to boost lean electrolyte Li–S battery performance. Finally, an outlook is provided to guide future research on high energy density Li–S batteries. | Hui Pan Zhibin Cheng Zhenyu Zhou Sijie Xie Wei Zhang Ning Han Wei Guo Jan Fransaer Jiangshui Luo Andreu Cabot Michael Wübbenhorst | 2023 | Nano-Micro Letters2023，15，10： | 2 |
| 4 | Enhancement and mapping of tolerance to salt stress and 5-fluorocytosine in synthetic yeast strains via SCRaMbLE显示文摘Varied environmental stress can affect cell growth and activity of the cellular catalyst.Traditional path of adaptive evolution generally takes a long time to achieve a tolerance phenotype,meanwhile,it is a challenge to dissect the underlying genetic mechanism.Here,using SCRaMbLE,a genome scale tool to generate random structural variations,a total of 222 evolved yeast strains with enhanced environmental tolerances were obtained in haploid or diploid yeasts containing six synthetic chromosomes.Whole genome sequencing of the evolved strains revealed that these strains generated different structural variants.Notably,by phenotypic-genotypic analysis of the SCRaMbLEd strains,we find that a deletion of gene YFR009W(GCN20)can improve salt tolerance of Saccharomyces cerevisiae,and a deletion of gene YER056C can improve 5-flucytosine tolerance of Saccharomyces cerevisiae.This study shows applications of SCRaMbLE to accelerate phenotypic evolution for varied environmental stress and to explore relationships between structural variations and evolved phenotypes. | Jianping Kang Jieyi Li Zhou Guo Sijie Zhou Shuxin Su Wenhai Xiao Yi Wu Yingjin Yuan | 2022 | Synthetic and Systems Biotechnology2022，7，3： | 2 |
| 5 | 3D Printing of Well Dispersed Electrospun PLGA Fiber Toughened Calcium Phosphate Scaffolds for Osteoanagenesis显示文摘Although the toughening of Calcium phosphate(CaP)scaffold by the addition of fiber has been well recognized,integrated mechanical,structural and functional considerations have been neglected in the design and fabrication of CaP scaffold implant.The emerging 3D printing provides a promising technique to construct CaP scaffold with precise size and elaborate microstructure.However,the most challenge is to extrude smoothly the CaP paste containing fibers for frequently-used extrusion-based 3D printing.In this study,frozen section and chemical dispersant(Pluronic F127,F127)were employed jointly to prepare non-aggregated polylactic-co-glycolic acid(PLGA)fibers.The injectability of CaP pastes with well dispersed PLGA fibers was more than 90%when the content of PLGA fibers was no more than 3 wt%.Meanwhile rheological property of CAP pastes with well dispersed fibers showed shear thinning,which were both beneficial to extrude CaP paste with well dispersed fibers for 3D printing.Moreover,these CaP scaffolds showed ductile fracture behavior due to the pullout and bridging effect of PLGA fibers.The cell proliferation and alkaline phosphatase(ALP)activity indicated that 3D printed CAP scaffold containing PLGA fibers possesses excellent biocompatibility and facilitate osteogenic differentiation ability.Thus,it was feasible to print CaP pastes with well dispersed PLGA fibers to construct toughening CaP scaffolds with the higher shape fidelity and complex structures,which had significant clinical potentials in osteoanagenesis due to their higher toughness and excellent biocompatibility. | Guoru Zhao Rongwei Cui You Chen Sijie Zhou Chen Wang Zhangmei Hu Xiaoke Zheng Maohong Li Shuxin Qu | 2020 | Journal of Bionic Engineering2020，17，4： | 2 |
| 6 | TPP1 as a versatile player at the ends of chromosomes显示文摘Telomeres,线性真核细胞的染色体的结束,是双人脚踏车 DNA 重复并且由各种各样的 telomeric 蛋白质盖住。这些核蛋白建筑群保护 telomeres 免受 DNA 的伤害损坏反应(DDR ) ,再结合,和端对端的熔化,保证染色体稳定性。人的 telosome/shelterin 建筑群是学习最好的联系 telomere 的蛋白质建筑群之一,由六核心 telomeric 蛋白质 TRF1, TRF2, TIN2, RAP1, POT1,和 TPP1 组成。TPP1,也已知的同样肾上腺皮质的发育异常蛋白质相当或相同的事物(ACD ) ,是 TEBP- 的一个通常认为的哺乳动物的相当或相同的事物并且属于 oligonucleotide 绑定(OB )-fold-containing 蛋白质家庭。三功能的域在 TPP1, N 终端 OB 褶层, POT1 有约束力的招募域(RD ) ,和 carboxyl 终端交往 TIN2 域(TID ) 以内被识别了。TPP1 能与 POT1 和 TIN2 交往维持 telomere 结构,并且调停为 telomere 延伸的 telomerase 招募。这些特征显示了 TPP1 玩在 telomere 的一个必要角色维护。这里,我们将考察重要调查结果加亮 TPP1 的功能的意义,与它和另外的 telosome 部件和 telomerase 的相互作用的一个焦点。我们将也在疾病治疗讨论潜在的含意。 | Sijie ZHANG | 2014 | Frontiers in Biology2014，9，3： | 1 |
| 7 | Dynamics of synthetic yeast chromosome evolution shaped by hierarchical chromatin organization显示文摘Synthetic genome evolution provides a dynamic approach for systematically and straightforwardly exploring evolutionary processes.Synthetic Chromosome Rearrangement and Modification by LoxP-mediated Evolution(SCRaMbLE)is an evolutionary system intrinsic to the synthetic yeast genome that can rapidly drive structural variations.Here,we detect over 260000 rearrangement events after the SCRaMbLEing of a yeast strain harboring 5.5 synthetic yeast chromosomes(synⅡ,synⅢ,synⅤ,circular synⅥ,synⅨR and synⅩ).Remarkably,we find that the rearrangement events exhibit a specific landscape of frequency.We further reveal that the landscape is shaped by the combined effects of chromatin accessibili and spatial contact probability.The rearrangements tend to occur in 3D spatially proximal and chromatin-accessible regions.The enormous numbers of rearrangements mediated by SCRaMbLE provide a driving force to potentiate directed genome evolution,and the investigation of the rearrangement landscape offers mechanistic insights into the dynamics of genome evolution. | Sijie Zhou Yi Wu Yu Zhao Zhen Zhang Limin Jiang Lin Liu Yan Zhang Jijun Tang Ying-Jin Yuan | 2023 | National Science Review2023，10，5： | 1 |
| 8 | Third-order trajectory planning for high accuracy point-topoint motion显示文摘This article studies a third-order trajectory planning method for point-to-point motion.All available instances for third-order trajectory planning are first analyzed.To distinguish those,three criteria are presented relying on trajectory characteristics.Following that,a fast preprocessing approach considering the trajectory as a whole is given based on the criteria constructed and system constraints.Also,the time-optimality of the trajectory is obtained.The relevant formulas are derived with the combination of geometrical symmetry of trajectory and area method.As a result,an accurate algorithm and its implementation procedure are proposed.The experimental results show the effectiveness and precision of the proposed method.The presented algorithm has been applied in semiconductor manufacturing equipment successfully. | Haihua MU Yunfei ZHOU Sijie YAN Aiguo HAN | 2009 | Frontiers of Electrical and Electronic Engineering in China2009，4，1： | 1 |
| 9 | Research on the Localisation of the Workpieces with Large Sculptured Surfaces in NC Machining显示文摘 | Zhou Yunfei Lai Xide | 2004 | International Journal of Advanced Manufacturing Technology2004，23，56： | 1 |
| 10 | Research on the method of precision evaluation and controlling for the cutter location path in five-axis machining显示文摘 | ZHOU Yunfei LI Bin YAN Sijie | 2005 | The International Journal of Advanced Manufacturing Technology2005，26，4： | 1 |
| 11 | Metal-organic framework-derived CoP_(2)@N-doped carbon hollow spheres for efficient oxygen evolution reaction显示文摘1.Introduction.Hydrogen is considered as a viable alternative to fossil fuels[1,2].Large-scale hydrogen production by electrochemical water splitting is regarded as an important approach.It consists of two half-reactions:hydrogen evolution reaction(HER)at the cathode and oxygen evolution reaction(OER)at the anode[3].Compared to the HER,the OER has sluggish kinetic and large overpotentials,re-sulting from the complex oxidation pathway[4,5].Although RuO_(2) and IrO_(2) have excellent catalytic OER performance[6],their large-scale deployment is unfeasible due to the scarcity and high cost of these noble metal elements.Thus,cheap OER electrocatalysts have been actively investigated[7]. | Wei Zhang Jiangshui Luo Xuan Zhang Wei Guo Ning Han Sijie Xie Zhenyu Zhou Zahid Anwer Zhenhong Xue Jan Fransaer | 2023 | Journal of Materials Science & Technology2023，，33： | 0 |
| 12 | Physical and toxicological profiles of human IAPP amyloids and plaques显示文摘Although much has been learned about the fibrillization kinetics, structure and toxicity of amyloid proteins, the properties of amyloid fibrils beyond the saturation phase are often perceived as chemically and biologically inert, despite evidence suggesting otherwise. To fill this knowledge gap, we examined the physical and biological characteristics of human islet amyloid polypeptide(IAPP) fibrils that were aged up to two months. Not only did aging decrease the toxicity of IAPP fibrils, but the fibrils also sequestered fresh IAPP and suppressed their toxicity in an embryonic zebrafish model. The mechanical properties of IAPP fibrils in different aging stages were probed by atomic force microscopy and sonication, which displayed comparable stiffness but age-dependent fragmentation, followed by self-assembly of such fragments into the largest lamellar amyloid structures reported to date. The dynamic structural and toxicity profiles of amyloid fibrils and plaques suggest that they play active, long-term roles in cell degeneration and may be a therapeutic target for amyloid diseases. | Aleksandr Kakinen Yunxiang Sun Ibrahim Javed Ava Faridi Emily H.Pilkington Pouya Faridi Anthony W.Purcell Ruhong Zhou Feng Ding Sijie Lin Pu Chun Ke Thomas P.Davis | 2019 | Science Bulletin2019，64，1： | 0 |
| 13 | Shipborne oceanic high-spectral-resolution lidar for accurate estimation of seawater depth-resolved optical properties显示文摘Lidar techniques present a distinctive ability to resolve vertical structure of optical properties within the upper water column at both day-and night-time.However,accuracy challenges remain for existing lidar instruments due to the ill-posed nature of elastic backscatter lidar retrievals and multiple scattering.Here we demonstrate the high performance of,to the best of our knowledge,the first shipborne oceanic high-spectral-resolution lidar(HSRL)and illustrate a multiple scattering correction algorithm to rigorously address the above challenges in estimating the depth-resolved diffuse attenuation coefficient Kd and the particulate backscattering coefficient bbp at 532 nm.HSRL data were collected during day-and night-time within the coastal areas of East China Sea and South China Sea,which are connected by the Taiwan Strait.Results include vertical profiles from open ocean waters to moderate turbid waters and first lidar continuous observation of diel vertical distribution of thin layers at a fixed station.The root-mean-square relative differences between the HSRL and coincident in situ measurements are 5.6%and 9.1%for Kd and bbp,respectively,corresponding to an improvement of 2.7-13.5 and 4.9-44.1 times,respectively,with respect to elastic backscatter lidar methods.Shipborne oceanic HSRLs with high performance are expected to be of paramount importance for the construction of 3D map of ocean ecosystem. | Yudi Zhou Yang Chen Hongkai Zhao Cedric Jamet Davide Dionisi Malik Chami Paolo Di Grolamo James H.Churnside Aleksey Malinka Huade Zhao Dajun Qiu Tingwei Cui Qun Liu Yatong Chen Sornsiri Phongphattarawat Nanchao Wang Sijie Chen Peng Chen Ziwei Yao Chengfeng Le Yuting Tao Peituo Xu Xiaobin Wang Binyu Wang Feitong Chen Chuang Ye Kai Zhang Chong Liu Dong Liu | 2022 | Light(Science & Applications)2022，11，10： | 0 |
| 14 | Digital Manufacture Techniques for Large Hydro Turbine's Blades显示文摘Blades are one of the vital components and most difficulty in manufacturing of large hydro turbines.In order to cost-effectively and productively manufacture these kinds of blades,a series of digital techniques in manufacturing have been devel- oped,which includes digital design of hydro turbine blades based on manufacture’ requirements,Computer-aided location and the machined error evaluation by using 3-dimensional digitized measuring,tool path generation strategy to meet requirements of en- hancing machining efficiency and controlling deviation in NC machining,tool path generation and NC machining simulation by es- tablishing a virtual NC machining environment for blades,and reasonable and feasible strategy and the systematic scheme for man- ufacturing of large blades by using 5-axis simultaneous CNC machining.The developed digital manufacture techniques have been successfully applied in manufacturing of both the large Kaplan and Francis hydraulic turbine blades;it shows that higher efficiency and the better surfaces finish accuracy can be achieved. | LAI Xide~1 ZHANG Qinghua~1 ZHOU Yunfei~2 YAN Sijie~2 1.School of Energy & Environment,Xihua University,Chengdu 610039,China 2.School of Mechanical Science,Huazhong University of Science and Technology,Wuhan 430074 ,China | 2006 | 武汉理工大学学报2006，28，S2： | 0 |
| 15 | Revealing the frequency-dependent oscillations in the nonlinear terahertz response induced by the Josephson current显示文摘Nonlinear responses of superconductors to intense terahertz radiation has been an active research frontier.Using terahertz pump-terahertz probe spectroscopy,we investigate the c-axis nonlinear optical response of a high-temperature superconducting cuprate.After excitation by a single-cycle terahertz pump pulse,the reflectivity of the probe pulse oscillates as the pump-probe delay is varied.Interestingly,the oscillatory central frequency scales linearly with the probe frequency,a fact widely overlooked in pump-probe experiments.By theoretically solving the nonlinear optical reflection problem on the interface,we show that our observation is well explained by the Josephson-type third-order nonlinear electrodynamics,together with the emission coefficient from inside the material into free space.The latter results in a strong enhancement of the emitted signal whose physical frequency is around the Josephson plasma edge.Our result offers a benchmark for and new insights into strong-field terahertz spectroscopy of related quantum materials. | Sijie Zhang Zhiyuan Sun Qiaomei Liu Zixiao Wang Qiong Wu Li Yue Shuxiang Xu Tianchen Hu Rongsheng Li Xinyu Zhou Jiayu Yuan Genda Gu Tao Dong Nanlin Wang | 2023 | National Science Review2023，10，11： | 0 |
| 16 | Rational design of Ruddlesden-Popper perovskite electrocatalyst for oxygen reduction to hydrogen peroxide显示文摘Although the oxygen reduction process to hydrogen peroxide(H_(2)O_(2))is a green option for H_(2)O_(2)generation,the low activity and selectivity hindered the industry's process.In recent years,the electrochemical synthesis of H_(2)O_(2)through a 2e-transfer method of oxygen reduction reaction(ORR)has piqued the interest of both academics and industry.Metal oxide catalysts have emerged as a novel family of electrochemical catalysts due to their unusual physical,chemical,and electrical characteristics.In this work,we first developed a Ruddlesden-Popper perovskite oxide(Pr_(2)NiO_(4+δ))as a highly selective and active catalyst for 2e-ORR to produce H_(2)O_(2).Molybdenum was introduced here to adjust the oxidation states of these transition metals with successful substitution into Ni-site to prepare Pr_(2)Ni1-xMoxO_(4+δ),and the molybdenum substitution improves the H_(2)O_(2)selectivity during the ORR process,in 0.1 M KOH,from 60%of Pr_(2)NiO_(4+δ)to 79%of Pr_(2)Ni_(0.8)Mo_(0.2)O_(4+δ)at 0.55 V versus RHE.A limiting H_(2)O_(2)concentration of_0.24 mM for Pr_(2)NiO_(4+δ)and 0.42 mM for Pr_(2)Ni_(0.8)Mo_(0.2)O_(4+δ)was obtained at a constant current of 10 mA/cm2 using a flow-cell reactor using a gas-diffusion electrode. | Ning Han Shihui Feng Wei Guo Omar Martinez Mora Xiaolin Zhao Wei Zhang Sijie Xie Zhenyu Zhou Zhiwei Liu Qiong Liu Kai Wan Xuan Zhang Jan Fransaer | 2022 | SusMat2022，2，4： | 0 |
| 17 | Development of a novel virus-like particle-based vaccine for preventing tick-borne encephalitis virus infection显示文摘Tick-borne encephalitis virus(TBEV)is an important tick-borne pathogen that poses as a serious public health concern.The coverage and immunogenicity of the currently available vaccines against TBEV are relatively low;therefore,it is crucial to develop novel and effective vaccines against TBEV.The present study describes a novel strategy for the assembly of virus-like particles(VLPs)by co-expressing the structural(core/prM/E)and non-structural(NS2B/NS3Pro)proteins of TBEV.The efficacy of the VLPs was subsequently evaluated in C57BL/6 mice,and the resultant IgG serum could neutralize both Far-Eastern and European subtypes of TBEV.These findings indicated that the VLP-based vaccine elicited the production of cross-subtype reactive antibodies.The VLPs provided protection to mice lacking the type I interferon receptor(IFNAR^(-/-))against lethal TBEV challenge,with undetectable viral load in brain and intestinal tissues.Furthermore,the group that received the VLP vaccine did not exhibit significant pathological changes and the inflammatory factors were significantly suppressed compared to the control group.Immunization with the VLP vaccine induced the production of multiple-cytokine-producing antiviral CD4+T cells in vivo,including TNF-α^(+),IL-2^(+),and IFN-γ^(+)T cells.Altogether,the findings suggest that noninfectious VLPs can serve as a potentially safe and effective vaccine candidate against diverse subtypes of TBEV. | Jielin Tang Muqing Fu Chonghui Xu Bao Xue Anqi Zhou Sijie Chen He Zhao Yuan Zhou Jizheng Chen Qi Yang Xinwen Chen | 2023 | Virologica Sinica2023，38，5： | 0 |
| 18 | Research and application of the virtual simulation system teaching method in copper pyrometallurgy显示文摘Copper pyrometallurgy has been holding a special place in the copper smelting industry.However,it is hard to explore the effect of parameters on production effectively due to the inoperable practice in the factory.The physical and chemical changes during the metallurgical process of copper smelting are also too complex to be observed.Therefore,we designed and built a virtual factory for copper pyrometallurgy,copper pyrometallurgy virtual simulation system(CPVSS),to simulate the copper smelting plant.The entire technical routes,system function,the main productive principle,technological process,and conditional tests were fully simulated in the CPVSS.It also provided a solution for the observation of internal phenomena in this paper.Moreover,sample computations were provided in this paper to illustrate the parameter simulation of the smelting process.A novel interactive experimental model was also constructed with virtual simulation technology and network multimedia technology,which provides powerful support for copper pyrometallurgy learning. | Sijie Zhou Dongming Zeng Chong Yan Jiaqi Huang Shuai Wang and Yonghua Zhou | 2021 | International Journal of Modeling, Simulation, and Scientific Computing2021，12，1： | 0 |
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