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您的检索式：作者名="Simon H.Jiang"
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| 1 | Understand SLE heterogeneity in the era of omics,big data,and artificial intelligence显示文摘Systemic lupus erythematosus(SLE)is a systemic autoimmune disease characterized by extraordinary heterogeneity,due to the complex pathogenesis and diverse manifestations.Stratification of patients for therapy and prognosis represents a major challenge to manage SLE.Conventional biomarkers for disease diagnosis and activity assessment provide very limited insight into immunological pathogenesis and therapeutic response rates.The advancement of“omics”technologies including genomics,transcriptomics,proteomics,and metabolomics has constituted an unprecedented opportunity to characterize the immunopathological landscape in individual patients with SLE.Indeed,genomic studies reveal a subset of SLE patients carrying one or more functional single nucleotide polymorphisms(SNPs)underlying immune dysregulation while transcriptomic studies have revealed subgroups in SLE patients showing distinct signatures for Type I interferon(TI-IFN)pathway activation or aberrant differentiation of B cells into plasma cells.This review will summarize results from the latest studies using omics technology to understand SLE heterogeneity.In addition,we propose that the application of artificial intelligence,such as by machine learning-based nonlinear dimensionality reduction method uniform manifold approximation and projection(UMAP)can further strengthen the analysis of omics big data.The combination of new technology and novel analysis pipeline can lead to breakthroughs in stratifying SLE patients for a better monitoring of disease activity and more precise design of treatment regime,not only for conventional immunosuppression but also novel immunotherapies targeting B-cell activating factor(BAFF),TI-IFN,and interleukin 2(IL-2). | Prianka Puri Simon H.Jiang Yang Yang Fabienne Mackay Di Yu | 2021 | Rheumatology & Autoimmunity2021，1，1： | 1 |
| 2 | Immunophenotyping identifies distinct cellular signatures for systemic lupus erythematosus and lupus nephritis显示文摘Background:Systemic lupus erythematosus(SLE)is a complex systemic autoimmune disease characterized by development of autoantibodies and multiorgan involvement.Kidney involvement,termed lupus nephritis,has major impact on life expectancy.It is increasingly recognized that SLE is likely a common clinical manifestation of pathophysiologically diverse processes,and lupus nephritis has similarly been associated with several distinct immunological processes.We compared the immune cell phenotypes of individuals with SLE in the presence or absence of nephritis.Methods:Cryopreserved peripheral blood mononuclear cells from SLE patients with and without kidney involvement underwent flow cytometric analysis to identify major populations in T cells,B cells and myeloid lineages.Results:We compared the frequencies of lymphocyte populations in 69 SLE patients without nephritis,20 SLE patients with nephritis,and 92 healthy blood donors.Patients with SLE and lupus nephritis(LN)had reduced marginal zone B cells(P<0.0001 in SLE;P=0.001 in LN),memory B cells(P=0.002 in SLE;P=0.001 in LN)and circulating T follicular helper(Tfh)memory cells(P<0.0001 in SLE and LN)compared to healthy donors.Patients with lupus nephritis had increase Th2(P<0.0001)and T regulatory cells(P<0.0001)compared to both SLE patients without nephritis and healthy donors.Conclusion:SLE patients with and without lupus nephritis have distinct immunologic differences that may reflect the unique pathophysiological processes contributing to disease manifestations. | Yi Tong V.Aw Phillip J.Whiley Ayla May Lorenzo Tom Lea-Henry Somasundhari Shanmuganandam Maurice Stanley Sonia N.Babu Vicki Athanasopoulos Jean Cappello Julia I.Ellyard Matthew Cook Carola Vinuesa Giles Walters David A.Fulcher Simon H.Jiang | 2023 | Rheumatology & Autoimmunity2023，3，1： | 0 |
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