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| 1 | Inactivation of Mitochondrial Complex Ⅰ Induces the Expression of a Twin Cysteine Protein that Targets and Affects Cytosolic, Chloroplastidic and Mitochondrial Function显示文摘At12Cys-1 (At5g64400 ) 和 At12Cys-2 (At5g09570 ) 是二密切相关的 isogenes 编码小、成双的半胱氨酸蛋白质,典型地在线粒体定位了。At12Cys-2 抄本与破坏 mitochondrial 蛋白质,而是 At12Cys 的增加在许多异种被导致蛋白质仅仅与减少的 mitochondrial 在异种被检测复杂我丰富。在缺乏 mitochondrial 建筑群的异种的 At12Cys 蛋白质感应我被位于线粒体,叶绿体,和 cytosol 的 At12Cys 蛋白质伴随。生物化学的分析揭示了那甚至单个的基因删除,即, At12cys-1 或 At12cys-2,在 mitochondrial 和叶绿体功能上有效果。然而,仅仅加倍异种,即, At12cys-1 : At12cys-2,影响许多蛋白质和 mRNA 抄本编码翻译延伸因素以及 rRNA 丰富。蓝本国的页证明 At12Cys 与 mitochondrial supercomplex 共同移居我 + III。同样, At12cys-1 和 At12cys-2 基因的删除,然而并非单个基因删除,导致提高的忍耐到干旱和轻应力和增加的抗氧化剂能力。正式就职和在在建筑群的减小之上的 At12Cys 的多重本地化我丰富提供机制明确地表明 mitochondrial 机能障碍到 cytosol 然后在以外到在房间的另外的细胞器。 | Yan Wang Wenhui Lyu Oliver Berkowitz Jordan D. Radomiljac Simon R. Law Monika W. Murcha Chris Carrie Pedro F. Teixeira Beata Kmiec Owen Duncan Olivier Van Aken Reena Narsai Elzbieta Glaser Shaobai Huang Ute Roessner A. Harvey Millar James Whelan | 2016 | Molecular Plant2016，9，5： | 5 |
| 2 | Superconducting single-photon detectors integrated with diamond nanophotonic circuits显示文摘Photonic quantum technologies hold promise to repeat the success of integrated nanophotonic circuits in non-classical applications.Using linear optical elements,quantum optical computations can be performed with integrated optical circuits and can therefore overcome the existing limitations in terms of scalability.In addition to passive optical devices for realizing photonic quantum gates,active elements,such as single-photon sources and single-photon detectors,are essential ingredients for future optical quantum circuits.Material systems that allow for the monolithic integration of all components are particularly attractive,including III-V semiconductors,silicon and diamond.Here,we demonstrate nanophotonic integrated circuits made from high-quality polycrystalline diamond thin films in combination with on-chip single-photon detectors.By using superconducting nanowires that are coupled evanescently to traveling waves,we achieve high detection efficiencies of up to 66%as well as low dark count rates and a timing resolution of 190 ps.Our devices are fully scalable and hold promise for functional diamond photonic quantum devices. | Patrik Rath Oliver Kahl Simone Ferrari Fabian Sproll Georgia Lewes-Malandrakis Dietmar Brink Konstantin Ilin Michael Siegel Christoph Nebel Wolfram Pernice | 2015 | Light(Science & Applications)2015，4，1： | 3 |
| 3 | Long-Term Follow-Up of Biopsy-Proven Viral Myocarditis显示文摘 | Stefan Grün Julia Schumm Simon Greulich Anja Wagner Steffen Schneider Oliver Bruder Eva-Maria Kispert Stephan Hill Peter Ong Karin Klingel Reinhardt Kandolf Udo Sechtem Heiko Mahrholdt | 2012 | Journal of the American College of Cardiology2012，，18： | 2 |
| 4 | Global spread of dengue virus types: mapping the 70-year history显示文摘 | Jane P. Messina Oliver J. Brady Thomas W. Scott Chenting Zou David M. Pigott Kirsten Duda Samir Bhatt Leah Katzelnick Rosalind E. Howes Katherine E. Battle Cameron P. Simmons Simon I. Hay | 2013 | Trends in Microbiology2013，，： | 2 |
| 5 | CMR Imaging Predicts Death and Other Adverse Events in Suspected Cardiac Sarcoidosis显示文摘 | Simon Greulich Claudia Christina Deluigi Steffen Gloekler Andreas Wahl Christine Zürn Ulrich Kramer Detlev Nothnagel Helmut Bültel Julia Schumm Stefan Grün Peter Ong Anja Wagner Steffen Schneider Kai Nassenstein Meinrad Gawaz Udo Sechtem Oliver Bruder Hei | 2013 | JACC: Cardiovascular Imaging2013，，： | 2 |
| 6 | Proximity operations of formation-flying spacecraft using an eccentricity/inclination vector separation显示文摘 | Simone D' Amico Oliver Montebruck | 2006 | Journal of Guidance Control and Dynamics2006，29，3： | 1 |
| 7 | Integrated Platform for Production and Purification of Human Pluripotent Stem Cell-Derived Neural Precursors显示文摘 | Gon?alo M. C. Rodrigues Andreia F. S. Matos Tiago G. Fernandes Carlos A. V. Rodrigues Michael Peitz Simone Haupt Maria Margarida Diogo Oliver Brüstle Joaquim M. S. Cabral | 2014 | Stem Cell Reviews and Reports2014，，2： | 1 |
| 8 | A randomised controlled trial comparing three analgesia regimens following total knee joint replacement:continuous femoral nerve block,intrathecal morphine or both显示文摘 | Olive DJ Barrington MJ Simone SA | 2015 | Anaesth Intensive Care2015，43，4： | 1 |
| 9 | Levels of Neonatal Thyroid Hormone in Preterm Infants and Neurodevelopmental Outcome at 5? Years: Millennium Cohort Study显示文摘 | Caroline Delahunty Shona Falconer Robert Hume Lesley Jackson Paula Midgley Marie Mirfield Simon Ogston Oliver Perra Judith Simpson Jennifer Watson Peter Willatts Fiona Williams | 2010 | The Journal of Clinical Endocrinology & Metabolism2010，，11： | 1 |
| 10 | An Overview of Existing Methods and Recent Advances in Sequential Monte Carlo 显示文摘 | Oliver Cappe Simon J Godsill Eric Moulines | 2007 | Proceedings of the IEEE(S0018-9219)2007，95，5： | 1 |
| 11 | Proximity operations of formation-flying spacecraft using an eccentricity/inclination vector separation 显示文摘 | Simone D Oliver M | 2006 | Journal of Guidance Control and Dynamics2006，29，3： | 1 |
| 12 | Modulation of Antioxidant Enzyme Expression and Function by Estrogen显示文摘 | Kerstin Strehlow Simone Rotter Sven Wassmann Oliver Adam Christian Grohé Kerstin Laufs Michael B?hm Georg Nickenig | 2003 | Circulation Research2003，，2： | 1 |
| 13 | Magnetic field amplification by slender cuboid- shaped magnetic concentrators with a single gap 显示文摘 | Simon B Oliver P | 2010 | Sensors and Actuators A : Physical2010，157，1： | 1 |
| 14 | Predictive impact of MGMT promoter methylation in glioblastoma of the elderly显示文摘 | Guido Reifenberger Bettina Hentschel J?rg Felsberg Gabriele Schackert Matthias Simon Oliver Schnell Manfred Westphal Wolfgang Wick Torsten Pietsch Markus Loeffler Michael Weller | 2012 | Int J Cancer2012，，6： | 1 |
| 15 | The WNT1^(G177C) mutation specifically affects skeletal integrity in a mouse model of osteogenesis imperfecta type XV显示文摘The recent identification of homozygous WNT1 mutations in individuals with osteogenesis imperfecta type XV(OI-XV)has suggested that WNT1 is a key ligand promoting the differentiation and function of bone-forming osteoblasts.Although such aninfluence was supported by subsequent studies,a mouse model of OI-XV remained to be established.Therefore,we introduced a previously identified disease-causing mutation(G177C)into the murine Wnt1 gene.Homozygous Wnt1^(G177C/G177C)mice were viable and did not display defects in brain development,but the majority of 24-week-old Wnt1^(G177C/G177C)mice had skeletal fractures.This increased bone fragility was not fully explained by reduced bone mass but also by impaired bone matrix quality.Importantly,the homozygous presence of the G177C mutation did not interfere with the osteoanabolic influence of either parathyroid hormone injection or activating mutation of LRP5,the latter mimicking the effect of sclerostin neutralization.Finally,transcriptomic analyses revealed that short-term administration of WNT1 to osteogenic cells induced not only the expression of canonical WNT signaling targets but also the expression of genes encoding extracellular matrix modifiers.Taken together,our data demonstrate that regulating bone matrix quality is a primary function of WNT1.They further suggest that individuals with WNT1 mutations should profit from existing osteoanabolic therapies. | Nele Vollersen Wenbo Zhao Tim Rolvien Fabiola Lange Felix Nikolai Schmidt Stephan Sonntag Doron Shmerling Simon von Kroge Kilian Elia Stockhausen Ahmed Sharaf Michaela Schweizer Meliha Karsak Bjorn Busse Ernesto Bockamp Oliver Semler Michael Amling Ralf Oheim Thorsten Schinke Timur Alexander Yorgan | 2021 | Bone Research2021，9，4： | 1 |
| 16 | The α 6 -integrin receptor in pancreatic carcinoma显示文摘 | Rolf J. Weinel Annette Rosendahl Elisabeth Pinschmidt Oliver Kisker Babette Simon Sentot Santoso | 1995 | Gastroenterology1995，，2： | 1 |
| 17 | Promiscuous affairs of PKB/AKT isoforms in metabolism显示文摘 | Simon M. Schultze J?rgen Jensen Brian A. Hemmings Oliver Tschopp Markus Niessen | 2011 | Archives of Physiology and Biochemistry2011，，2： | 1 |
| 18 | ASTER Mineral Index Processing Manual显示文摘 | Aleks Kalinowski Simon Oliver | 2004 | Remote Sensing Applications Geoscience Australia2004，，： | 1 |
| 19 | Is There “One” DLPFC in Cognitive Action Control? Evidence for Heterogeneity From Co-Activation-Based Parcellation显示文摘 | Edna C. Cieslik Karl Zilles Svenja Caspers Christian Roski Tanja S. Kellermann Oliver Jakobs Robert Langner Angela R. Laird Peter T. Fox Simon B. Eickhoff | 2013 | Cerebral Cortex2013，，11： | 1 |
| 20 | Big Data Analytics for Earth Sciences:the EarthServer approach显示文摘Big Data Analytics is an emerging field since massive storage and computing capabilities have been made available by advanced e-infrastructures.Earth and Environmental sciences are likely to benefit from Big Data Analytics techniques supporting the processing of the large number of Earth Observation datasets currently acquired and generated through observations and simulations.However,Earth Science data and applications present specificities in terms of relevance of the geospatial information,wide heterogeneity of data models and formats,and complexity of processing.Therefore,Big Earth Data Analytics requires specifically tailored techniques and tools.The EarthServer Big Earth Data Analytics engine offers a solution for coverage-type datasets,built around a high performance array database technology,and the adoption and enhancement of standards for service interaction(OGC WCS and WCPS).The EarthServer solution,led by the collection of requirements from scientific communities and international initiatives,provides a holistic approach that ranges from query languages and scalability up to mobile access and visualization.The result is demonstrated and validated through the development of lighthouse applications in the Marine,Geology,Atmospheric,Planetary and Cryospheric science domains. | Peter Baumann Paolo Mazzetti Joachim Ungar Roberto Barbera Damiano Barboni Alan Beccati Lorenzo Bigagli Enrico Boldrini Riccardo Bruno Antonio Calanducci Piero Campalani Oliver Clements Alex Dumitrua,Mike Grant Pasquale Herzig George Kakaletris John Laxton Panagiota Koltsida Kinga Lipskoch Alireza Rezaei Mahdiraji Simone Mantovani Vlad Merticariu Antonio Messina Dimitar Misev Stefano Natali Stefano Nativi Jelmer Oosthoek Marco Pappalardo James Passmore Angelo Pio Rossi Francesco Rundo Marcus Sen Vittorio Sorbera Don Sullivan Mario Torrisi Leonardo Trovato Maria Grazia Veratelli Sebastian Wagner | 2016 | International Journal of Digital Earth2016，9，1： | 1 |
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