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| 1 | Mineral and bone disorder after kidney transplantation显示文摘After successful kidney transplantation, accumulated waste products and electrolytes are excreted and regulatory hormones return to normal levels. Despite the improvement in mineral metabolites and mineral regulating hormones after kidney transplantation,abnormal bone and mineral metabolism continues to present in most patients. During the first 3 mo, fibroblast growth factor-23(FGF-23) and parathyroid hormone levels decrease rapidly in association with an increase in 1,25-dihydroxyvitamin D production. Renal phosphate excretion resumes and serum calcium, if elevated before, returns toward normal levels. FGF-23 excess during the first 3-12 mo results in exaggerated renal phosphate loss and hypophosphatemia occurs in some patients. After 1 year, FGF-23 and serum phosphate return to normal levels but persistent hyperparathyroidism remains in some patients. The progression of vascular calcification also attenuates. High dose corticosteroid and persistent hyperparathyroidism are the most important factors influencing abnormal bone and mineral metabolism in long-term kidney transplant(KT) recipients. Bone loss occurs at a highest rate during the first 6-12 mo after transplantation. Measurement of bone mineral density is recommended in patients with estimated glomerular filtration rate > 30 mL/min. The use of active vitamin D with or without bisphosphonate is effective in preventing early post-transplant bone loss. Steroid withdrawal regimen is also beneficial in preservation of bone mass in long-term. Calcimimetic is an alternative therapy to parathyroidectomy in KT recipients with persistent hyperparathyroidism. If parathyroidectomy is required, subtotal to near total parathyroidectomy is recommended. Performing parathyroidectomy during the waiting period prior to transplantation is also preferred in patients with severe hyperparathyroidism associated with hypercalcemia. | Pahnwat T Taweesedt Sinee Disthabanchong | 2015 | World Journal of Transplantation2015，5，4： | 2 |
| 2 | Colloidal synthesis of non-equilibrium wurtzite-type MnSe显示文摘 | Sines I T Misra R Schiller P | 2010 | Angewandte Chemic International Edition2010，49，27： | 1 |
| 3 | Digital screening methodology for the directed evolution of transglycosidases 显示文摘 | Kone F M T Bechec L M Sine J P | 2009 | Protein Engineering Design and Selection2009，22，1： | 1 |
| 4 | Gamma- and delta-subunits regulate the affinity and the cooperativity of ligand binding to the acetylcholine receptor显示文摘 | Sine SM Claudio T | 1991 | J Biol Chem1991，266，19： | 1 |
| 5 | The caspase-cleaved DAP5 protein supports internal ribosome entry site-mediated translation of death proteins 显示文摘 | Henis-Korenblit S Shani G Sines T | 2002 | Proc Natl Acad Sci U S A2002，99，8： | 1 |
| 6 | Thromboxane, prostacyclin, and, leukotrienes in cerebral ischemia 显示文摘 | Sine T Chen (hung Y Hsu Ldwar(1 L | 1986 | Neurology1986，36，4： | 1 |
| 7 | Liquid-Phase Synthesis of Uniform Cube-Shaped GeTe Microcrystals 显示文摘 | Buck M R Sines I T Schaak R E | 2010 | Chemistry of Materials2010，22，10： | 1 |
| 8 | Hemorrhage Relatere Reexploration Following Open Heart Surgery:The Impact of Per-Operative and Post-Operative Coagulation Testing显示文摘 | Hall T S Sines J C Spotnitz A J | 2002 | Cardiovasc Surg2002，10，2： | 1 |
| 9 | CD56bright natural killer (NK) cells:an important NK cell subset显示文摘 | POLI A MICHEL T TH(E)R(E)SINE M | | 0，，04： | 1 |
| 10 | Hemorrhage Relatere Reexploration Following Open Heart Surgery: The Impact of Per-Operative and Post-Operative Coagulation Testing显示文摘 | Hall T S Sines J C Spotnitz A J | 2002 | Cardiovasc Surg2002，10，2： | 1 |
| 11 | A search for growth related genes in Kalanchoe blossfeldiana 显示文摘 | SINE H T SOREN K R HEIKO M | 2009 | Plant Physiology and Bio- chemistry2009，47，11： | 1 |
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