| 1 | A microexplosive shockwave-based drug delivery microsystem for treating hard-to-reach areas in the human body显示文摘Implantable drug-delivery microsystems have the capacity to locally meet therapeutic requirements by maximizing local drug efficacy and minimizing potential side effects.The internal organs of the human body including the esophagus,gastrointestinal tract,and respiratory tract,with anfractuos contours,all manifest with endoluminal lesions often located in a curved or zigzag area.The ability of localized drug delivery for these organs using existing therapeutic modalities is limited.Spraying a drug onto these areas and using the adhesion and water absorption properties of the drug powder to attach to lesion areas can provide effective treatment.This study aimed to report the development and application of microsystems based on microshockwave delivery of drugs.The devices comprised a warhead-like shell with a powder placed at the head of the device and a flexible rod that could be inserted at the tail.These devices had the capacity to deposit drugs on mucous membranes in curved or zigzag areas of organs in the body.The explosive impact characteristics of the device during drug delivery were analyzed by numerical simulation.In the experiment of drug delivery in pig intestines,we described the biosafety and drug delivery capacity of the system.We anticipate that such microsystems could be applied to a range of endoluminal diseases in curved or zigzag regions of the human body while maximizing the on-target effects of drugs. | Yi Sun Wenzhong Lou Hengzhen Feng Wenting Su Sining Lv | 2022 | Microsystems & Nanoengineering2022，8，5： | 0 |
| 2 | A Camouflaged Film Imitating the Chameleon Skin with Color-Changing Microfluidic Systems Based on the Color Information Identification of Background显示文摘To adapt to a complex and variable environment,self-adaptive camouflage technology is becoming more and more important in all kinds of military applications by overcoming the weakness of the static camouflage.In nature,the chameleon can achieve self-adaptive camouflage by changing its skin color in real time with the change of the background color.To imitate the chameleon skin,a camouflaged film controlled by a color-changing microfluidic system is proposed in this paper.The film with microfluidic channels fabricated by soft materials can achieve dynamic cloaking and camouflage by circulating color liquids through channels inside the film.By sensing and collecting environmental color change information,the control signal of the microfluidic system can be adjusted in real time to imitate chameleon skin.The microstructure of the film and the working principle of the microfluidic color-changing system are introduced.The mechanism to generate the control signal by information processing of background colors is illustrated.“Canny”double-threshold edge detection algorithm and color similarity are used to analyze and evaluate the camouflage.The tested results show that camouflaged images have a relatively high compatibility with environmental backgrounds and the dynamic cloaking eff ect can be achieved. | Huanhuan Li Tianhang Yang Lujia Li Sining Lv Songjing Li | 2021 | Journal of Bionic Engineering2021，18，5： | 0 |
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