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| 1 | Role of sex hormones in gastrointestinal motility in pregnant and non-pregnant rats显示文摘AIM: To correlate gastric contractility, gastrointestinal transit, and hormone levels in non-pregnant(estrous cycle) and pregnant rats using noninvasive techniques. METHODS: Female rats(n = 23) were randomly divided into(1) non-pregnant,(contractility, n =6; transit, n = 6); and(2) pregnant(contractility, n = 5; transit, n = 6). In each estrous cycle phase or at 0, 7, 14, and 20 d after the confirmation of pregnancy, gastrointestinal transit was recorded by AC biosusceptometry(ACB), and gastric contractility was recorded by ACB and electromyography. After each recording, blood samples were obtained for progesterone and estradiol determination. RESULTS: In the estrous cycle, despite fluctuations of sex hormone levels, no significant changes in gastrointestinal motility were observed. Days 7 and 14 of pregnancy were characterized by significant changes in the frequency of contractions(3.90 ± 0.42 cpm and 3.60 ± 0.36 cpm vs 4.33 ± 0.25 cpm) and gastric emptying(168 ± 17 min and 165 ± 15 min vs 113 ± 15 min) compared with day 0. On these same days, progesterone levels significantly increased compared with control(54.23 ± 15.14 ng/m L and 129.96 ± 30.52 ng/mL vs 13.25 ± 6.31 ng/mL). On day 14, we observed the highest level of progesterone and the lowest level of estradiol compared with day 0(44.3 ± 15.18 pg/mL vs 24.96 ± 5.96 pg/mL). CONCLUSION: Gastrointestinal motility was unaffected by the estrous cycle. In our data, high progesterone and low estradiol levels can be associated with decreased contraction frequency and slow gastric emptying. | Juliana Fernandes Matos Madileine Francely Americo Yuri Karen Sinzato Gustavo Tadeu Volpato Luciana Aparecida Corá Marcos Felipe Freitas Calabresi Ricardo Brandt Oliveira Debora Cristina Damasceno Jose Ricardo Arruda Miranda | 2016 | World Journal of Gastroenterology2016，22，25： | 5 |
| 2 | Evaluation of neonatally induced mild diabetesin rats Maternal and fetal repercussions显示文摘 | Iessi IL Bueno A Sinzato YK | | 0，，01： | 1 |
| 3 | Animal models for clinical and gestational diabetes:maternal and fetal outcomes显示文摘 | Kiss AC Lima PH Sinzato YK | | 0，，： | 1 |
| 4 | Effects of exposure tocigarette smoke prior to pregnancy in diabetic rats显示文摘 | Damasceno DC Sinzato YK Lima PH | 2011 | DiabetolMetab Syndr2011，18，3： | 1 |
| 5 | Necrotizing lymphadenitis presenting as mesenteric lymphadenopathy显示文摘 | Yabe H Sinzato I Hashimoto K | | 0，，08： | 1 |
| 6 | Neonatally induced mild diabetes in rats and its effect on maternal,placental,and fetal parameters显示文摘 | Sinzato YK Volpato GT Iessi IL | 2012 | Exp Diabetes Res2012，2012，10： | 1 |
| 7 | Animal models for clinical and gestational diabetes: maternal and fetal outcomes 显示文摘 | Kiss AC Lima PH Sinzato YK | 2009 | Diabetol Metab2009，11，1： | 1 |
| 8 | Neonatally induced mild diabetes in rats and its effect on maternal, placental, and fetal parameters 显示文摘 | Sinzato YK Volpato GT Iessi IL | 2012 | Exp Diabetes Res2012，2012，10： | 1 |
| 9 | Effect of Morus nigraaqueous extract treatment on the maternal-fetal outcome,oxidativestress status and lipid profile of streptozotocin-induced diabetic rats显示文摘 | Volpato G T Calderon I M P Sinzato S | 2011 | J Ethnopharmacol2011，138，3： | 1 |
| 10 | Comparison of methods for the identification of coagulase-negativestaphylococci 显示文摘 | Maria de Lourdes RS Cunha Yuri K Sinzato Liciana VA Silveira | 2004 | Mem6rias do Instituto Os- waldo Cruz2004，99，8： | 1 |
| 11 | Evaluation of level of DNA damage in blood leukocytes of nondiabetic and diabetic rat exposed to cigarette smoke显示文摘 | Lima PH Sinzato YK de Souza Mda S | 2006 | Mutat Res2006，22，6： | 1 |
| 12 | Effect of maternal obesity on diabetes development in adult rat offspring显示文摘 | De Campos K E Sinzato Y K Pimenta Wde P | 2007 | Life Sci2007，81，1920： | 1 |
| 13 | Evaluation of level of DNA damage in blood leukocytes of non-diabetic and diabetic rat exposed to cigarette smoke 显示文摘 | Lima P H O Sinzato Y K M Souza da S S de | 2007 | Mutation Research2007，628，： | 1 |
| 14 | Neonatally induced mild diabetes in rats and its effect on maternal, placental, and fetal parameters 显示文摘 | SINZATO YK VOLPATO GT IESSI IL | 2012 | Exp Diabetes Res2012，，3： | 1 |
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