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| 1 | Clinical experience in cell - based therapeutics: disc chondrocyte transplantation a treatment for degenerated or damaged intervertebral disc显示文摘 | Meisel HJ Siodla V Oaney T | 2007 | Biomol Eng2007，24，： | 1 |
| 2 | Investigation of transformer model winding deformation using sweep frequency response analy- sis显示文摘 | Ludwikowski K Siodla K Ziomek W | 2012 | IEEE Transactions on Dielectrics and Electrical Insulation2012，19，6： | 1 |
| 3 | Differential expression of mucin 1 and mucin 2 in colorectal cancer显示文摘AIM To determine tissue expression(mRNA, protein) of two types of mucins [mucin 1(MUC1) and mucin 2(MUC2)] in patients with colorectal cancer(CRC).METHODS Expression of membrane-bound mucin(MUC1) and secretory mucin(MUC2) in CRC(mRNA, protein) were analyzed in tissue material including fragments of tumorsobtained from CRC patients(n = 34), and fragments of normal colorectal tissue from the same patients(control). The analysis was conducted using real-time quantitative polymerase chain reaction(RT-qPCR)(transcripts), immunohistochemistry(IHC)(apomucins), and the modern approach for morphometric analysis of IHC reaction(HSV filter software). Results on tissue expression of both mucins(mRNA, protein) were compared to histological alterations in colorectal cancer samples and correlated with selected clinical data in the patients. The statistical analysis was conducted using Statistica PL v. 12.0 software.RESULTS Significantly higher expression of the MUC1 mRNA in the CRC, compared with the control and the borderline correlation of mRNA expression with MUC1 protein levels in colorectal samples was observed. The expression of apomucins concerned cell membranes(MUC1) and cytoplasm(MUC2) and occurred both in control tissues and in most cancerous samples. There were no significant relationships between MUC1(mRNA, protein) and the clinicopathological data of patients. MUC2 protein expression was significantly lower as compared to the control, while MUC2 mRNA expression was comparable in both groups. The MUC1/MUC2 ratio was significantly higher in CRC tissues than in the control. The higher expression of MUC2 was a feature of mucinous CRC subtypes, and characterized higher histological stage of tumors. Negative correlations have been obtained between MUC2 and the Ki-67 antigen, as well as between MUC2 and p53 protein expressions in CRC.CONCLUSION A combination of tissue overexpression of MUC1, reduced MUC2 expression, and high ratio of MUC1/MUC2 is a factor of poor prognosis in CRC patients. MUC2 tissue expression allows to differentiate mucinous and nonmucinous CRC subtypes. | Aldona Kasprzak Elzbieta Siodla Malgorzata Andrzejewska Jacek Szmeja Agnieszka Seraszek-Jaros Szczepan Cofta Witold Szaflarski | 2018 | World Journal of Gastroenterology2018，24，36： | 1 |
| 4 | Clinical experience in cell -based therapeutics:disc chondroeyle transplantation a treatment for degenerated or damaged intervertebral disc显示文摘 | Mcisel H J Siodla V Ganey T | 2007 | Biomol Eng2007，24，： | 1 |
| 5 | Breakdown of SF6 in non-uni- form field gaps under combined de fast oscillating impulse and standard lightning impulse voltages显示文摘 | Siodla K Kuffel E Fujinami H | 1993 | IEEE Transaetions on Dielectrics and Electrical Insulation1993，28，2： | 1 |
| 6 | Clinical experience in cell- based therapeutics:disc chondrocyte transplantation A treatment for degenerated or damaged intervertebral disc 显示文摘 | Meisel H J Siodla V Ganey T | 2007 | Biomol Eng2007，24，1： | 1 |
| 7 | Breakdown of SF6 in non-uniform field gaps under combined dc fast oscillating impulse and standard lightning impulse voltages显示文摘 | Siodla K Kuffel E Fujinami H | 1993 | IEEE Transactions on Electrical Insulation1993，28，2： | 1 |
| 8 | Investigation of transformer model winding deformation using sweep frequency response analy- sis显示文摘 | Ludwikowski K Siodla K Ziomek W | 2012 | IEEE Transactions on Dielectrics and Electrical Insulation2012，19，6： | 1 |
| 9 | Clinical experience in cell-based therapeutics:disc chondrocyte transplantation:a treatment for degenerated or damaged intervertebral disc显示文摘 | Meisel HJ Siodla V Ganey TM | 2007 | Biomol Eng2007，24，1： | 1 |
| 10 | Clinica l experience in cel based therapeutics:disc chondrocyte transplantation A treatment for degenerated or damaged intervertebral disc显示文摘 | Meisel HJ Siodla V Ganey T | | 0，，01： | 1 |
| 11 | Clinical experience in cel -based therapeutics:disc chondrocyte transplantation A treatment for degenerated or damaged intervertebral disc显示文摘 | Meisel HJ Siodla V Ganey T | | 0，，01： | 1 |
| 12 | Clinical experience in cell based therapeutics: disc chondrocyte transplantation a treatment for degenerated or damaged intervertebral disc 显示文摘 | Meisel HI Siodla V Ganey T | 2007 | Biomol Eng2007，1，： | 1 |
| 13 | Breakdown of SF6 in non-uiform field gaps under combined DC,fast osicillating impulse and standard lighting impulse voltages显示文摘 | Siodla K Kuffel E Fujinami H | | 0，，02： | 1 |
| 14 | Clinical experience in cell-based therapeutics:disc chondrocyte transplantation A treatment for degenerated or damaged intervertebral disc显示文摘 | Meisel HJ Siodla V Ganey T | 2007 | Biomol Eng2007，24，1： | 1 |
| 15 | Invesfigation of transformer model winding deformation using sweep frequency response analysis显示文摘 | Ludwikowski K Siodla K | 2012 | IEEE Transactions on Dielectrics and Electrical Insulation2012，9，6： | 1 |
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