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| 1 | Spectral analysis of bowel sounds in intestinal obstruction using an electronic stethoscope显示文摘AIM: To determine the value of bowel sounds analysis using an electronic stethoscope to support a clinical diagnosis of intestinal obstruction. METHODS: Subjects were patients who presented with a diagnosis of possible intestinal obstruction based on symptoms, signs, and radiological findings. A 3MTH Littmann Model 4100 electronic stethoscope was used in this study. With the patients lying supine, six 8-second recordings of bowel sounds were taken from each patient from the lower abdomen. The recordings were analysed for sound duration, soundto-sound interval, dominant frequency, and peak frequency. Clinical and radiological data were reviewed and the patients were classified as having either acute, subacute, or no bowel obstruction. Comparison of bowel sound characteristics was made between these subgroups of patients. In the presence of an obstruction, the site of obstruction was identified and bowel calibre was also measured to correlate with bowel sounds. RESULTS: A total of 71 patients were studied during the period July 2009 to January 2011. Forty patientshad acute bowel obstruction (27 small bowel obstruction and 13 large bowel obstruction), 11 had subacute bowel obstruction (eight in the small bowel and three in large bowel) and 20 had no bowel obstruction (diagnoses of other conditions were made). Twenty-five patients received surgical intervention (35.2%) during the same admission for acute abdominal conditions. A total of 426 recordings were made and 420 recordings were used for analysis. There was no significant difference in sound-to-sound interval, dominant frequency, and peak frequency among patients with acute bowel obstruction, subacute bowel obstruction, and no bowel obstruction. In acute large bowel obstruction, the sound duration was significantly longer (median 0.81 s vs 0.55 s, P = 0.021) and the dominant frequency was significantly higher (median 440 Hz vs 288 Hz, P = 0.003) when compared to acute small bowel obstruction. No significant difference was seen between acute large bowel obstruction and large bowel pseudoobstruction. For patients with small bowel obstruction, the sound-to-sound interval was significantly longer in those who subsequently underwent surgery compared with those treated non-operatively (median 1.29 s vs 0.63 s, P < 0.001). There was no correlation between bowel calibre and bowel sound characteristics in both acute small bowel obstruction and acute large bowel obstruction. CONCLUSION: Auscultation of bowel sounds is nonspecific for diagnosing bowel obstruction. Differences in sound characteristics between large bowel and small bowel obstruction may help determine the likely site of obstruction. | Siok Siong Ching Yih Kai Tan | 2012 | World Journal of Gastroenterology2012，18，33： | 14 |
| 2 | 心脏再同步治疗对心肌复极的影响及其潜在致心律失常作用显示文摘目的以双心室起搏为核心技术的心脏再同步治疗技术(CRT)用于治疗慢性心力衰竭(CHF)时可能引起心肌复极异常而具有潜在的致心律失常危险性。本研究以接受CRT的CHF患者为对象,观察反映心肌复极特性的心电图指标在不同部位起搏时的变化及差异,并结合患者转归探讨其意义。方法21例接受CRT和/或CRT-D治疗的CHF患者入选。在植入术过程中或者复查时,将CRT装置分别程控为右心室心内膜起搏(RV-Endo)、左心室心外膜起搏(LV-Epi)和双心室起搏(Biv),同步记录12导联心电图,测量心电图上反映复极时间和复极差异的指标QT间期、JT间期和Tp-e间期,并在不同起搏部位间比较这些参数的差异。结果准确反映心肌复极时间的JT间期和公认代表心肌跨室壁复极离散的Tp-e间期均在LV-Epi起搏时最长[(341.78±61.69)ms,(199.70±62.44)ms],Biv起搏时次之[(325.86±59.19)ms,(184.89±74.08)ms],RV-Endo起搏时最短[(286.14±38.68)ms,(146.41±31.16)ms],三者比较差异有统计学意义(P<0.0001)。QT间期的变化有类似趋势但差异无统计学意义。在(29.18±18.38)个月的随访期中,共发生4例死亡,其中1例猝死,1例发生“心律失常风暴”并最终死于无休止性室性心动过速。结论在CHF患者已有器质性心肌病变的基础上,左心室心外膜起搏和目前CRT采用的双心室起搏延长心肌复极时间并增大跨室壁心肌复极离散,从而为促进恶性心律失常的发生提供了“基质”。 | 吕家高 林立 白融 Wee Siong Teo Ruth Kam 王琳 | 2006 | 中华心律失常学杂志2006，10，2： | 10 |
| 3 | Systematic review of the outcomes of surgical resection for intermediate and advanced Barcelona Clinic Liver Cancer stage hepatocellular carcinoma:A critical appraisal of the evidence显示文摘AIM To perform a systematic review to determine the survival outcomes after curative resection of intermediate and advanced hepatocellular carcinomas(HCC).METHODS A systematic review of the published literature was performed using the PubM ed database from 1 st January 1999 to 31 st Dec 2014 to identify studies that reported outcomes of liver resection as the primary curative treatment for Barcelona Clinic Liver Cancer(BCLC) stage B or C HCC. The primary end point was to determine the overall survival(OS) and disease free survival(DFS) of liver resection of HCC in BCLC stage B or C in patients with adequate liver reserve(i.e., Child's A or B status). The secondary end points were to assess the morbidity and mortality of liver resection in large HCC(defined as lesions larger than 10 cm in diameter) and to compare the OS and DFS after surgical resection of solitary vs multifocal HCC.RESULTS We identified 74 articles which met the inclusion criteria and were analyzed in this systematic review. Analysis of the resection outcomes of the included studies were grouped according to(1) BCLC stage B or C HCC,(2) Size of HCC and(3) multifocal tumors. The median 5-year OS of BCLC stage B was 38.7%(range 10.0-57.0); while the median 5-year OS of BCLC stage C was 20.0%(range 0.0-42.0). The collective median 5-year OS of both stages was 27.9%(0.0-57.0). In examining the morbidity and mortality following liver resection in large HCC, the pooled RR for morbidity [RR(95%CI) = 1.00(0.76-1.31)] and mortality [RR(95%CI) = 1.15(0.73-1.80)] were not significant. Within the spectrum of BCLC B and C lesions, tumors greater than 10 cm were reported to have median 5-year OS of 33.0% and multifocal lesions 54.0%.CONCLUSION Indication for surgical resection should be extended to BCLC stage B lesions in selected patients. Further studies are needed to stratify stage C lesions for resection. | Ye Xin Koh Hwee Leong Tan Weng Kit Lye Juinn Huar Kam Adrian Kah Heng Chiow Siong San Tan Su Pin Choo Alexander Yaw Fui Chung Brian Kim Poh Goh | 2018 | World Journal of Hepatology2018，10，6： | 10 |
| 4 | P2P信息检索及其优化策略显示文摘本文研究对等计算(P2P)环境中语义丰富的信息检索及其优化策略,提出了P2P信息检索系统(PIRS),实现了P2P环境中语义丰富的信息检索,定义了一套评价PIRS效率的指标体系;明确了决定PIRS效率的关键因素并提出相应的解决策略,包括:基于向量空间模型的节点数据分类管理策略、基于节点聚类的系统数据管理策略以及自适应查询路由策略,并用实验结果验证了这些策略的有效性。 | 凌波 吕永成 周水庚 周傲英 Ng Wee Siong | 2006 | 计算机科学2006，33，8： | 8 |
| 5 | Colorectal liver metastases: Current management and future perspectives显示文摘The liver is the commonest site of metastatic disease for patients with colorectal cancer,with at least 25%developing colorectal liver metastases(CRLM)during the course of their illness.The management of CRLM has evolved into a complex field requiring input from experienced members of a multi-disciplinary team involving radiology(cross sectional,nuclear medicine and interventional),Oncology,Liver surgery,Colorectal surgery,and Histopathology.Patient management is based on assessment of sophisticated clinical,radiological and biomarker information.Despite incomplete evidence in this very heterogeneous patient group,maximising resection of CRLM using all available techniques remains a key objective and provides the best chance of long-term survival and cure.To this end,liver resection is maximised by the use of downsizing chemotherapy,optimisation of liver remnant by portal vein embolization,associating liver partition and portal vein ligation for staged hepatectomy,and combining resection with ablation,in the context of improvements in the functional assessment of the future remnant liver.Liver resection may safely be carried out laparoscopically or open,and synchronously with,or before,colorectal surgery in selected patients.For unresectable patients,treatment options including systemic chemotherapy,targeted biological agents,intraarterial infusion or bead delivered chemotherapy,tumour ablation,stereotactic radiotherapy,and selective internal radiotherapy contribute to improve survival and may convert initially unresectable patients to operability.Currently evolving areas include biomarker characterisation of tumours,the development of novel systemic agents targeting specific oncogenic pathways,and the potential reemergence of radical surgical options such as liver transplantation. | Jack Martin Angelica Petrillo Elizabeth C Smyth Nadeem Shaida Samir Khwaja HK Cheow Adam Duckworth Paula Heister Raaj Praseedom Asif Jah Anita Balakrishnan Simon Harper Siong Liau Vasilis Kosmoliaptsis Emmanuel Huguet | 2020 | World Journal of Clinical Oncology2020，11，10： | 5 |
| 6 | 房室旁道经导管射频消融后复发及对策显示文摘 | 戴剑 Teo Wee Siong Ruth Kam | 2004 | 心脏杂志2004，16，4： | 3 |
| 7 | Virtual Reality Simulation of Fuzzy-logic Control during Underwater Dynamic Positioning显示文摘在这份报纸,为模拟和用设计环境的 MATLAB 图形用户界面的遥远地操作的车辆(ROV ) 的模糊逻辑的控制的 graphical-user-interface (图形用户界面) 软件被建议。建议 ROV 图形用户界面平台系统地并且交互地允许象系统设计与象 proportional-integral-derivative (PID ) 那样的另外的控制器相比的模糊逻辑的控制那样的控制器和滑动模式控制器(SMC ) 。象海电流那样的外部骚乱能被增加改进建模在实际在水下环境。模仿的结果证明模糊逻辑的控制的位置回答在海水流骚乱下面展出合理性能。 | Midhin Das Thekkedan Cheng Siong Chin Wai Lok Woo | 2015 | Journal of Marine Science and Application2015，14，1： | 3 |
| 8 | 双腔埋藏式心脏复律除颤器显示文摘双腔埋藏式心脏复律除颤器 (ICD)可提供起搏及抗室性和房性心律失常的治疗。报道 11例双腔ICD应用的临床体会。男 8例、女 3例 ,年龄 6 0 .5 5± 10 .0 7岁。缺血性心脏病 9例、Brugada综合征 1例、缺血性心脏病合并肥厚型梗阻性心脏病 1例。双腔ICD安置指征有 :室上性快速心律失常伴室性快速心律失常 6例 ,室性快速性心律失常伴房室阻滞 1例、伴左室功能不全 4例 ;临床上明确记录到室性心动过速 (简称室速 )、心室颤动 (简称室颤 )和室上性快速心律失常者分别为 8,2和 5例。 8例病人术前进行电生理检查 ,诱发出持续性室速 6例、室颤 2例 ;3例行电生理检查 ,其中 2例太虚弱、1例为反复发作持续性室速。 5例安置具有心室转复除颤伴心房、心室起搏的ICD ,5例安置具有心房、心室起搏转复及除颤的ICD ,1例安置具有双心室起搏及心室转复、除颤的ICD。所有病人在置入ICD时都进行除颤阈值的测定。总共有 2 3次室颤被诱发 ,除颤阈值为 12 .0 9± 5 .2 4J,除颤电极阻抗为 44 .0 0±11.0 5Ω ,P波和R波电压幅度分别为 3.5 3± 1.32mV ,13.42± 4.73mV ,心房、心室起搏阈值分别为 1.39± 0 .71和 0 .91± 0 .38V。随访 8.82± 5 .0 0 (2~ 19)个月 ,5例共有 12 0次持续性室速发生 ,其中 118次经抗心动过速起搏成功? | 陈颖敏 Hsu LiFeng Ruth KAM Teo Wee Siong | 2001 | 中国心脏起搏与心电生理杂志2001，15，4： | 2 |
| 9 | 射频消融治疗快速性心律失常的并发症及预防显示文摘目的 探讨快速性心律失常经导管射频消融治疗过程中的并发症及预防。方法 DSA下经导管射频消融治疗 314例快速性心律失常。其中室上性心动过速 2 4 2例 ,房颤 2 1例 ,室性心动过速 14例 ,心房扑动 35例。结果 所有病例经射频消融治疗后总成功率为 91.8% ,发生Ⅲ度房室传导阻滞 2例 ,总发生率为 0 .6 3% ,Ⅰ度房室传导阻滞 2例 ,发生率 0 .6 3% ,气胸 4例 ,发生率 1.2 4 % ,下肢动脉栓塞1例 ,发生率 0 .32 % ,术中或术后发生迷走亢进 (表现心率减慢、出汗、血压下降、恶心、呕吐 ) 6例 ,发生率为 1.9%。结论 射频消融治疗快速性心律失常的并发症不可能完全避免。但前 10 0例患者出现的并发症明显高于 10 0例后的病例 (11/ 4 )。手术者丰富的心脏电生理和心脏影像学结构知识 。 | 戴剑 曹恒献 汤涌 田洁 Teo Wee Siong | 2004 | 介入放射学杂志2004，13，S2： | 2 |
| 10 | Treatment of Helicobacter pylori in surgical practice:A randomised trial of triple versus quadruple therapy in a rural district general hospital显示文摘AIM: To compare a lansoprazole-based triple versus quadruple therapy for Helicobacter pylori (H pylori) eradication with emphasis on side effect prof ile,patient compliance and eradication rate at a rural district general hospital in Wales,United Kingdom. METHODS: One hundred one patients with H pylori infection were included in the study. Patients were randomised to receive triple therapy comprising of lansoprazole 30 mg,amoxycillin 1 g,clarithromycin 500 mg,all b.d. (LAC),or quadruple therapy comprising of lansoprazole 30 mg b.d.,metronidazole 500 mg t.d.s.,bismuth subcitrate 240 mg b.d.,and tetracycline chloride 500 mg q.d.s. (LMBT). Cure was defi ned as a negative 13C urea breath test 2 mo after treatment. RESULTS: Seven patients were withdrawn after randomisation. Fifty patients were assigned to LAC group and 44 to LMBT group. The intention-to-treat cure rates were 92% and 91%,whereas the per-protocol cure rates were 92% and 97%,respectively. Side effects were common,with 56% experiencingmoderate to severe symptoms in the LAC group and 59% in the LMBT group. Symptoms of vomiting,diarrhoea and black stools were significantly more common in the LMBT group. Patient compliance was 100% for triple therapy and 86% for quadruple therapy (P < 0.01). One-third of patients in both groups were still taking acid-reducing medications at six-month follow-up. CONCLUSION: One-week triple and quadruple therapies have similar intention-to-treat eradication rates. Certain side effects are more common with quadruple therapy,which can compromise patient compliance. Patient education or modifi cations to the regimen are alternative options to improve compliance of the quadruple regimen. | Siok Siong Ching Sivakumaran Sabanathan Lloyd R Jenkinson | 2008 | World Journal of Gastroenterology2008，14，24： | 2 |
| 11 | Clinacanthus nutans Extracts Are Antioxidant with Antiproliferative Effect on Cultured Human Cancer Cell Lines显示文摘 | Yoke Keong Yong Jun Jie Tan Soek Sin Teh Siau Hui Mah Gwendoline Cheng Lian Ee Hoe Siong Chiong Zuraini Ahmad José Luis Ríos | 2013 | Evidence-Based Complementary and Alternative Medicine2013，，： | 2 |
| 12 | 抗心动过速起搏器识别、预防和终止快速房性心律失常的有效性分析显示文摘目的研究评价抗心动过速DDDRP起搏器对识别、预防和终止快速房性心律失常(atrialtachyarrhythmia,ATA)的有效性。方法研究对象为因病态窦房结综合征合并ATA而置入DDDRP起搏器(Medtronic,AT500/AT501)的患者24例。起搏器的心房预防性起搏(atrialpreventivepacing,APP)方案由主治医生决定是否或者何时开启,ATA的监测和抗心动过速起搏(anti-tachycardiapacing,ATP)功能则在置入术后随即激活。回放起搏器存储的心律失常事件和心内电图,核对、分析起搏器识别ATA的准确性和ATP终止ATA的效率,同时比较在APP功能开启前后患者ATA负荷的差异。结果24例患者在(17.63±8.79)个月的随访期内均无事件生存,无起搏器相关并发症。12例患者起搏器的APP功能始终是关闭状态,6例患者在第一次术后随访时开启,另有6例的APP功能在随访至9.29个月时激活。24台起搏器共记录到97367阵次的ATA,在有心内电图记录的阵次中,起搏器对ATA识别正确率为(76.77±20.52)%;ATP终止ATA的有效率为(50.27±19.29)%。尽管APP功能开启后的心房起搏比例(87.95±20.93)%较开启前(50.73±34.46)%明显增高(P<0.01),但是患者的ATA负荷(14.73%与16.52%或7.52h/周与6.58h/周)和最长单阵ATA持续时间(27.27h与20.75h)差异均无统计学意义(P>0.05)。结论DDDRP起搏器能识别和诊断大多数(75%)的房性心律失常,适时发放的ATP治疗可超速抑制、终止约50%的房性心动过速或心房扑动;APP功能提高心房起搏的比例,但从整体上并不能明显减少ATA的发作和降低患者的ATA负荷。 | 白融 王铁锚 林立 Ruth Kam Wee Siong Teo 王琳 | 2006 | 中华心血管病杂志2006，34，4： | 2 |
| 13 | A nano-particle based approach to improve filtration control of water based muds under high pressure high temperature conditions显示文摘There have been many attempts to improve the filtration control of water based muds under High Pressure High Temperature(HPHT)condition using a cost effective approach.Nano particles are perhaps the best option considering their successful applications reported in many studies.However,they are often expensive and pose unfavourably changes on the rheology of the muds.In this paper,an attempt was made to show the application of Nano Glass Flakes(NGFs)as a cheap but effective nano particle to control the filtration of water based muds under HPHT conditions.Performing a series of rheology,filtration and conductivity tests on the mud samples with unmodified NGFs revealed that this nano particle increases the mud rheology,yield point and gel strength of the mud with a slight impact on the filtration loss.However,by modifying the surface charges of NGFs with a cationic surfactant,filtration loss was significantly reduced without any severe impacts on the mud rheology.Considering the conductivity of the mud which increases by adding the modified NGF,this nano particle might be a good choice to improve the overall performance of water based muds under HPHT conditions. | Ong Siong Guan Raoof Gholami Arshad Raza Minou Rabiei Nikoo Fakhari Vamegh Rasouli Omid Nabinezhad | 2020 | Petroleum2020，6，1： | 2 |
| 14 | Incidental non-benign gallbladder histopathology after cholecystectomy in an United Kingdom population: Need for routine histological analysis?显示文摘AIM To analyse the range of histopathology detected in the largest published United Kingdom series of cholecystectomy specimens and to evaluate the rational for selective histopathological analysis.METHODS Incidental gallbladder malignancy is rare in the United Kingdom with recent literature supporting selective histological assessment of gallbladders after routine cholecystectomy.All cholecystectomy gallbladder specimens examined by the histopathology department at our hospital during a five year period between March 2008 and March 2013 were retrospectively analysed.Further data was collected on all specimens demonstrating carcinoma,dysplasia and polypoid growths.RESULTS The study included 4027 patients.The majority(97%) of specimens exhibited gallstone or cholecystitis related disease.Polyps were demonstrated in 44(1.09%),the majority of which were cholesterol based(41/44).Dysplasia,ranging from low to multifocal high-grade was demonstrated in 55(1.37%).Incidental primary gallbladder adenocarcinoma was detected in 6 specimens(0.15%,5 female and 1 male),and a single gallbladder revealed carcinoma in situ(0.02%).This large single centre study demonstrated a full range of gallbladder disease from cholecystectomy specimens,including more than 1% neoplastic histology and two cases of macroscopically occult gallbladder malignancies.CONCLUSION Routine histological evaluation of all elective and emergency cholecystectomies is justified in a United Kingdom population as selective analysis has potential to miss potentially curable life threatening pathology. | Krashna Patel Khaled Dajani Satheesh Iype Nikolaos A Chatzizacharias Saranya Vickramarajah Susan Davies Rebecca Brais Siong S Liau Simon Harper Asif Jah Raaj K Praseedom Emmanuel L Huguet | 2016 | World Journal of Gastrointestinal Surgery2016，8，10： | 2 |
| 15 | Dynamics of phytoplankton and picoplankton over a tidal cycle in a subtropical lagoon显示文摘The influences of a tidal cycle on the distribution of autotrophic plankton were investigated in a hyper-eutrophic lagoon designated as a scenic area.Results showed that the highest concentrations of picoplankton and phytoplankton were found in the middle and inner part of the lagoon,irrespective of the tides.The MDS result also revealed that phytoplankton communities,dominated by Ceratium furca,were similar among stations in the inner bay during both flood tides and ebb tides.The time series sampling results at the inlet-outlet channel revealed that almost the same amounts of phytoplankton and picoplankton were carried through the channel during flood and ebb tides,with no trend in nutrient fluctuations except for phosphate which had a net loss from the lagoon.The results showed that tidal cycles do not effectively flush away phytoplankton and picoplankton from the lagoon,and the blooming of phytoand picoplankton is inevitable should the situation stay the same.Steps are needed to alleviate the eutrophication condition instead of depending on the natural process such as tidal cycle. | TEW Kwee Siong MENG Pei-Jie LEE Hung-Jen YE Yi-Xiu KUO Jimmy FANG Lee-Shing CHOU Wei-Rung | 2010 | Chinese Science Bulletin2010，55，23： | 2 |
| 16 | Gender differences in the trend of colorectal cancer incidence in Singapore, 1968–2002显示文摘 | Inge M. C. M. Kok Chia Siong Wong Kee Seng Chia Xueling Sim Chuen Seng Tan Lambertus A. Kiemeney Helena M. Verkooijen | 2008 | International Journal of Colorectal Disease2008，，5： | 1 |
| 17 | Institutions and economic development: A Granger causality analysis of panel data evidence显示文摘 | Siong Hook Law Thong Cheen Lim Normaz Wana Ismail | 2013 | Economic Systems2013，，4： | 1 |
| 18 | Determination and Validation of Reference Gene Stability for qPCR Analysis in Polysaccharide Hydrogel-Based 3D Chondrocytes and Mesenchymal Stem Cell Cultural Models显示文摘 | Wai Hon Chooi Ruijie Zhou Suan Siong Yeo Feng Zhang Dong-An Wang | 2013 | Molecular Biotechnology2013，，2： | 1 |
| 19 | Institutional Infrastructure and Economic Performance: Dynamic Panel Data Evidence显示文摘 | Siong Hook Law A. N. Bany-Ariffin | 2008 | Transition Studies Review2008，，3： | 1 |
| 20 | 参数不确定及有扰动的情况下欠驱动遥控无人潜水器鲁棒性建模、滑模控制及仿真研究(英文)显示文摘A dynamic model of a remotely operated vehicle(ROV)is developed.The hydrodynamic damping coefficients are estimated using a semi-predictive approach and computational fluid dynamic software ANSYS-CFX?and WAMIT?.A sliding-mode controller(SMC)is then designed for the ROV model.The controller is subsequently robustified against modeling uncertainties,disturbances,and measurement errors.It is shown that when the system is subjected to bounded uncertainties,the SMC will preserve stability and tracking response.The paper ends with simulation results for a variety of conditions such as disturbances and parametric uncertainties. | Mostafa Eslami Cheng Siong Chin Amin Nobakhti | 2019 | Journal of Marine Science and Application2019，18，2： | 1 |
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