|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Therapeutic aspects of c-MYC signaling in inflammatory and cancerous colonic diseases显示文摘Colonic inflammation is required to heal infections, wounds, and maintain tissue homeostasis. As the seventh hallmark of cancer, however, it may affect all phases of tumor development, including tumor initiation, promotion, invasion and metastatic dissemination, and also evasion immune surveillance. Inflammation acts as a cellular stressor and may trigger DNA damage or genetic instability, and, further, chronic inflammation can provoke genetic mutations and epigenetic mechanisms that promote malignant cell transformation. Both sporadical and colitis-associated colorectal carcinogenesis are multi-step, complex processes arising from the uncontrolled proliferation and spreading of malignantly transformed cell clones with the obvious ability to evade the host's protective immunity. In cells upon DNA damage several protooncogenes, including c-MYC are activated in parelell with the inactivation of tumor suppressor genes. The target genes of the c-MYC protein participate in different cellular functions, including cell cycle, survival, protein synthesis, cell adhesion, and microRNA expression. The transcriptional program regulated by c-MYC is context dependent, therefore the final cellular response to elevated c-MYC levels may range from increased proliferation to augmented apoptosis. Considering physiological intestinal homeostasis, c-MYC displays a fundamental role in the regulation of cell proliferation and crypt cell number. However, c-MYC gene is frequently deregulated in inflammation, and overexpressed in both sporadic and colitis-associated colon adenocarcinomas. Recent results demonstrated that endogenous c-MYC is essential for efficient induction of p53-dependent apoptosis following DNA damage, but c-MYC function is also involved in and regulated by autophagy-related mechanisms, while its expression is affected by DNA-methylation, or histone acetylation. Molecules directly targeting c-MYC, or agents acting on other genes involved in the c-MYC pathway could be selected for combined regiments. However, due to its context-dependent cellular function, it is clinically essential to consider which cytotoxic drugs are used in combination with c-MYC targeted agents in various tissues. Increasing our knowledge about MYCdependent pathways might provide direction to novel anti-inflammatory and colorectal cancer therapies. | Ferenc Sipos Gábor Firneisz Györgyi Mũzes | 2016 | World Journal of Gastroenterology2016，22，35： | 9 |
| 2 | A comprehensive characterization of pancreatic ductal carcinoma cell lines: towards the establishment of an in vitro research platform显示文摘 | Bence Sipos Simone M?ser Holger Kalthoff Virag T?r?k Matthias L?hr Günter Kl?ppel | 2003 | Virchows Archiv2003，，5： | 4 |
| 3 | Association of hepatocyte-derived growth factor receptor/caudal type homeobox 2 co-expression with mucosal regeneration in active ulcerative colitis显示文摘AIM:To characterize the regeneration-associated stem cell-related phenotype of hepatocyte-derived growth factor receptor(HGFR)-expressing cells in active ulcerative colitis(UC).METHODS:On the whole 38 peripheral blood samples and 38 colonic biopsy samples from 18 patients with histologically proven active UC and 20 healthy control subjects were collected.After preparing tissue microarrays and blood smears HGFR,caudal type homeobox 2(CDX2),prominin-1(CD133) and Musashi-1conventional and double fluorescent immunolabelings were performed.Immunostained samples were digitalized using high-resolution Mirax Desk instrument,and analyzed with the Mirax TMA Module software.For semiquantitative counting of immunopositive lamina propria(LP) cells 5 fields of view were counted at magnification x 200 in each sample core,then mean ± SD were determined.In case of peripheral blood smears,30 fields of view with 100 μm diameter were evaluated in every sample and the number of immunopositive cells(mean ± SD) was determined.Using 337 nm UVA Laser MicroDissection system at least 5000 subepithelial cells from the lamina propria were collected.Gene expression analysis of HGFR,CDX2,CD133,leucine-rich repeat-containing G-protein coupled receptor 5(Lgr5),Musashi-1 and cytokeratin20(CK20) were performed in both laser-microdisscted samples and blood samples by using real time reverse transcription polymerase chain reaction(RT-PCR).RESULTS:By performing conventional and double fluorescent immunolabelings confirmed by RT-PCR,higher number of HGFR(blood:6.7 ± 1.22 vs 38.5 ±3.18;LP:2.25 ± 0.85 vs 9.22 ± 0.65;P < 0.05),CDX2(blood:0 vs 0.94 ± 0.64;LP:0.75 ± 0.55 vs 2.11± 0.75;P < 0.05),CD133(blood:1.1 ± 0.72 vs 8.3± 1.08;LP:11.1 ± 0.85 vs 26.28 ± 1.71;P < 0.05)and Musashi-1(blood and LP:0 vs scattered) positive cells were detected in blood and lamina propria of UC samples as compared to controls.HGFR/CDX2(blood:0 vs 1± 0.59;LP:0.8 ± 0.69 vs 2.06 ± 0.72,P < 0.05)and Musashi-1/CDX2(blood and LP:0 vs scattered) coexpressions were found in blood and lamina propria of UC samples.HGFR/CD133 and CD133/CDX2 coexpressions appeared only in UC lamina propria samples.CDX2,Lgr5 and Musashi-1 expressions in UC blood samples were not accompanied by CK20 mRNA expression.CONCLUSION:In active UC,a portion of circulating HGFR-expressing cells are committed to the epithelial lineage,and may participate in mucosal regeneration by undergoing mesenchymal-to-epithelial transition. | Ferenc Sipos Miklós Constantinovits Gábor Valcz Zsolt Tulassay Gy?rgyi M?zes | 2015 | World Journal of Gastroenterology2015，21，28： | 2 |
| 4 | Bioconversion ofindustrial hemp to ethanol and methane : The benefits ofsteam pretreatment and co- production 显示文摘 | Kreuger E Sipos B Zacchi G | 2011 | BioresourceTechnology2011，102，3： | 1 |
| 5 | Autoimmune pancreatitis: pathological findings显示文摘 | Kloppel G Luttges J Sipos B | 2005 | JOP2005，6，： | 1 |
| 6 | psychological pro- file of hungarian national young ice hockey players 显示文摘 | Geczi G Toth L Sipos K | 2009 | Kinesiology2009，41，1： | 1 |
| 7 | Fungal ATP-binding cassette (ABC) transporters in drug resistance & detoxification显示文摘 | Sipos G Kuchler K | 2006 | Curr Drug Targets2006，7，4： | 1 |
| 8 | The Behavior of Matrix metallo- proteinase - 9 in lymphocytic colitis, collagenous colitis and ulcer - ative eolitis显示文摘 | Lakatos G Sipos F Miheller P | 2011 | Pathol Oncol Res2011，7，16： | 1 |
| 9 | Expression of Lymphangiogenic Factors and Evidence of Intratumoral Lymphangiogenesis in Pancreatic Endocrine Tumors显示文摘 | Bence Sipos Wolfram Klapper Marie-Luise Kruse Holger Kalthoff Dontscho Kerjaschki Günter Kl?ppel | 2004 | The American Journal of Pathology2004，，4： | 1 |
| 10 | Autoimmune pancreati- tis:pathologieal findings显示文摘 | Kloppel G Luttges J Sipos B | 2005 | J Pancreas2005，6，： | 1 |
| 11 | The impact of hampering innovation factors on innovation performance--European countries case显示文摘 | Sipos G L Bzoi G Ionescu A | 2014 | Procedia--Social and Behavioral Sciences2014，124，： | 1 |
| 12 | Autoimmune pan- creatitis : pathological findings 显示文摘 | Kloppel G Luttges J Sipos B | 2005 | JOP2005，6，1： | 1 |
| 13 | Quantification of punctate iron sources using magnetic resonance phase 显示文摘 | McAuley G Schrag M Sipos P | 2010 | Magnetic Resonance Med2010，63，： | 1 |
| 14 | The role of the bone marrow derived mesenchymal stem cells in colonic epithelial regeneration显示文摘 | Valcz G Krenács T Sipos F | | 0，，01： | 1 |
| 15 | Elevated osteopontin expression and proliferative/apoptotic ratio in the coloreetal adenoma-dysplasia- carcinoma sequence 显示文摘 | Valcz G Sipos F KrenOcs T | 2010 | Pathol Oncol Res2010，16，4： | 1 |
| 16 | Regeneration associated growth factor receptor and epithelial marker expression in lymphoid aggregates of ulcerative colitis显示文摘 | Sipos F1 Muzes G Valcz G | 2010 | Scand J Gastroenterol2010，45，4： | 1 |
| 17 | Genetic profile of 22 pancreatic carcinoma cell lines显示文摘 | Patrick S. Moore Bence Sipos Simonetta Orlandini Claudio Sorio Francisco X. Real Nicholas R. Lemoine Thomas Gress Claudio Bassi Günter Kl?ppel Holger Kalthoff Hendrik Ungefroren Matthias L?hr Aldo Scarpa | 2001 | Virchows Archiv2001，，6： | 1 |
| 18 | Soi31/Ravlp functions at the early endosome to regulate endocytic trafficking to the vacuole and localization of trans-Golgi network transmembrane proteins显示文摘 | Sipos G Rnckner JH Brace EJ | | 0，，07： | 1 |
| 19 | Importance of carcinoma-associated fibroblast-derived proteins in clinical oncology显示文摘 | Valcz G Sipos F Tulassay Z | 2014 | J Clin Pathol2014，67，12： | 1 |
| 20 | Chemical speciation in concentrated alkalino aluminate solutions in sodium, potassium and caesium media: Interpretation of the unusual variations of the observed hydroxide activity显示文摘 | SIPOS P SCHIBECI M PEINTLER G MAYA P M HEFTERA G | 2006 | Dalton Transactions2006，15，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员