|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Epithelial toll-like receptor 9 signaling in colorectal inflammation and cancer: Clinico-pathogenic aspects显示文摘Toll-like receptors (TLRs) recognize specific motifs which are frequently present in bacteria, fungi, prokaryotes and viruses. Amongst TLRs, TLR9 can be activated by such bacterial or viral DNA fragments, immunoglobulin-DNA complexes or synthetic oligonucleotides, which all contain unmethylated cytosineguanine nucleotide sequences (CpGs). Emerging data indicate that TLR9 signaling has a role in, and may influence, colorectal carcinogenesis and colonic inflammation. CpGs are classified into three groups according to their influence on both the antigen-specific humoraland cellular immunity, and the production of type 1 interferons and proinflammatory cytokines. TLR9 activation via CpGs may serve as a new therapeutic target for several cancerous and various inflammatory conditions. Due to its probable anti-cancer effects, the application possibilities of TLR9-signaling modulation may be extremely diverse even in colorectal tumors. In this review we aimed to summarize the current knowledge about TLR-signaling in the pathogenesis and therapy of inflammatory bowel diseases and colorectal cancer. Due to the species-specific differences in TLR9 expression, however, one must be careful in translating the animal model data into the human system, because of the differences between CpG-oligodeoxynucleotide-responsive cells. TLR9 agonist DNA-based immunomodulatory sequences could also represent a promising therapeutic alternative in systemic inflammatory conditions and chronic colonic inflammations as their side effects are not significant. | István Fri Ferenc Sipos Tiana M Germann Alexandra Kalmár Zsolt Tulassay Béla Molnár Gyrgyi Mzes | 2013 | World Journal of Gastroenterology2013，19，26： | 14 |
| 2 | Contribution of TLR signaling to the pathogenesis of colitisassociated cancer in inflammatory bowel disease显示文摘In the intestine a balance between proinflammatory and repair signals of the immune system is essential for the maintenance of intestinal homeostasis. The innate immunity ensures a primary host response to microbial invasion, which induces an inflammatory process to localize the infection and prevent systemic dissemination of pathogens. The key elements of this process are the germline encoded pattern recognition receptors inclu-ding Toll-like receptors(TLRs). If pathogens cannot be eliminated, they may elicit chronic inflammation, which may be partly mediated via TLRs. Additionally, chronic inflammation has long been suggested to trigger tissue tumorous transformation. Inflammation, the seventh hallmark of cancer, may affect all phases of tumor development, and evade the immune system. Inflammation acts as a cellular stressor and may trigger DNA damage or genetic instability. Furthermore, chronic inflammation can provoke genetic mutations and epigenetic mechanisms that promote malignant cell transformation. Colorectal cancers in inflammatory bowel disease patients are considered typical examples of inflammation-related cancers. Although data regarding the role of TLRs in the pathomechanism of cancer-as-sociated colitis are rather conflicting, functionally these molecules can be classified as 'largely antitumorigenic' and 'largely pro-tumorigenic' with the caveat that the underlying signaling pathways are mainly context(i.e., organ-, tissue-, cell-) and ligand-dependent. | Ferenc Sipos István Fri Miklós Constantinovits Zsolt Tulassay Gyrgyi Mzes | 2014 | World Journal of Gastroenterology2014，20，36： | 9 |
| 3 | Prophylactic transcatheter arterial embolization reduces rebleeding in non-variceal upper gastrointestinal bleeding: A meta-analysis显示文摘BACKGROUND Despite the improvement in the endoscopic hemostasis of non-variceal upper gastrointestinal bleeding(NVUGIB),rebleeding remains a major concern.AIM To assess the role of prophylactic transcatheter arterial embolization(PTAE)added to successful hemostatic treatment among NVUGIB patients.METHODS We searched three databases from inception through October 19th,2020.Randomized controlled trials(RCTs)and observational cohort studies were eligible.Studies compared patients with NVUGIB receiving PTAE to those who did not get PTAE.Investigated outcomes were rebleeding,mortality,reintervention,need for surgery and transfusion,length of hospital(LOH),and intensive care unit(ICU)stay.In the quantitative synthesis,odds ratios(ORs)and weighted mean differences(WMDs)were calculated with the random-effects model and interpreted with 95%confidence intervals(CIs).RESULTS We included a total of 3 RCTs and 9 observational studies with a total of 1329 patients,with 486 in the intervention group.PTAE was associated with lower odds of rebleeding(OR=0.48,95%CI:0.29–0.78).There was no difference in the 30-d mortality rates(OR=0.82,95%CI:0.39–1.72)between the PTAE and control groups.Patients who underwent PTAE treatment had a lower chance for reintervention(OR=0.48,95%CI:0.31–0.76)or rescue surgery(OR=0.35,95%CI:0.14–0.92).The LOH and ICU stay was shorter in the PTAE group,but the difference was non-significant[WMD=-3.77,95%CI:(-8.00)–0.45;WMD=-1.33,95%CI:(-2.84)–0.18,respectively].CONCLUSION PTAE is associated with lower odds of rebleeding and any reintervention in NVUGIB.However,further RCTs are needed to have a higher level of evidence. | Eszter Boros Zoltán Sipos Péter Hegyi Brigitta Teutsch Levente Frim Szilárd Váncsa Szabolcs Kiss FanniDembrovszky Eduard Oštarijaš Andrew Shawyer Bálint Erőss | 2021 | World Journal of Gastroenterology2021，27，40： | 2 |
| 4 | Isolation of epsilon-haemoglobin-chain positive fetal cells with micromanipulation for prenatal diagnosis显示文摘 | Nagy GR Bán Z Sipos F | 2005 | Prenat Diagn2005，25，14： | 1 |
| 5 | Matrix Metalloproteinase-9 Expression in the Normal Mucosa–Adenoma–Dysplasia–Adenocarcinoma Sequence of the Colon显示文摘 | László Herszényi Ferenc Sipos Orsolya Galamb Norbert Solymosi István Hritz Pál Miheller Lajos Berczi Béla Molnár Zsolt Tulassay | 2008 | Pathology & Oncology Research2008，，1： | 1 |
| 6 | Transposition of ovaries during radical hysterectomy for cervical cancer显示文摘 | Sipos N Szantho A Csapo Z | 2002 | Orv Hetil2002，143，4： | 1 |
| 7 | Limitations of pH - potentiometrie titration for the determination of the degree of deaectvlation of chitosan显示文摘 | BALAZS N SIPOS P | 2007 | Carbohydr Res2007，324，26： | 1 |
| 8 | Molecular-weight distribution, analytical and spectroscopic characterization of humic fraetions sequentially isolated by organic-solvents from a brown coal humie acid显示文摘 | Senesi N Sipos S | 1985 | Organic Geochemistry1985，8，2： | 1 |
| 9 | Limitations of pH-potentiometric titration for the determination of the degree of deacetylation of chitosan显示文摘 | Balazs N Sipos P | 2007 | Carbohydrate Research2007，342，1： | 1 |
| 10 | Periodontal ligament and gingival fibroblasts from periodontitis patients are more active in interaction with Porphyromonas gingivalis 显示文摘 | Scheres N Laine ML Sipos PM | 2011 | J Periodontal Res2011，46，4： | 1 |
| 11 | Carcinoma arising in enterocutan fistulae of Crohn’s disease patients: description of two cases显示文摘 | Tamás Zágoni Zoltán Péter Ferenc Sipos Csaba Dicházi Zsolt Tarján István Dobó Ilona Kaszás Zsolt Tulassay | 2006 | International Journal of Colorectal Disease2006，，5： | 1 |
| 12 | Limitations of pH-potentiometric titration for the determination of the degree of deacetylation of chitosan显示文摘 | Nándor Balázs Pál Sipos | 2006 | Carbohydrate Research2006，，1： | 1 |
| 13 | Periodontal ligament and gingival fibroblasts from periodontitis patients are more active in interaction with Porphyromonas gingivalis显示文摘 | Scheres N Laine ML Sipos PM | 2011 | J Periodontal Res2011，17，10： | 1 |
| 14 | Synthesis, structure and photocalalytic properties of Fe( Ⅲ)-doped TiO2 prepared from TiCt3 显示文摘 | Ambrus Z Balazs N Alapi T Wittmann G Sipos P Dombi A Mogyorosi K | 2008 | Appl Catal B: Environ2008，81，12： | 1 |
| 15 | Limitations of pH-potentio-metric titration for the determination of the degree ofdeacetylation of chitosan显示文摘 | BALAZS N SIPOS P | 2007 | Carbohydrate Research2007，342，1： | 1 |
| 16 | Effect of soil composition on adsorption of lead as reflected by a study on a natural forest soil profile显示文摘 | Péter Sipos Tibor Németh Ilona Mohai István Dódony | 2004 | Geoderma2004，，3： | 1 |
| 17 | Diagnostic mRNA expression patterns of inflamed, benign, and malignant colorectal biopsy specimen and their correlation with peripheral blood results显示文摘 | Galamb O Sipos F Solymosi N Spisdk S Krendcs T Teth K | 2008 | Cancer Epidemiol Biomarkers Prey2008，17，： | 1 |
| 18 | Periodontal ligament and gingival fibroblasts from periodontitis patients are more active in in- teraction with Porphyromonas gingivalis 显示文摘 | Scheres N Laine ML Sipos PM | 2011 | J Period Res2011，46，4： | 1 |
| 19 | Sorption of copper,zinc andlead on soil mineral phases显示文摘 | SIPOS P N METH T KIS V K | 2008 | Chemosphere2008，73，4： | 1 |
| 20 | Heavy metal retention by soil mineral phases during a potential soil contamination by sewage sludge显示文摘 | Péter Sipos Tibor Németh Viktória Kováics Kis Ilona Mohai | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员