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| 1 | Current concepts in total femoral replacement显示文摘Total femoral replacement(TFR) is a salvage arthroplasty procedure used as an alternative to lower limb amputation. Since its initial description in the mid-20^(th) century, this procedure has been used in a variety of oncologic and non-oncologic indications. The most compelling advantage of TFR is the achievement of immediate fixation which permits early mobilization. It is anticipated that TFR will be increasingly performed as the rate of revision arthroplasty rises worldwide. The existing literature is mainly composed of a rather heterogeneous mix of retrospective case series and a wide assortment of case reports. Numerous TFR prostheses are currently available and the surgeon must understand the unique implications of each implant design. Long-term functional outcomes are dependent on adherence to proper technique and an appropriate physical therapy program for postoperative rehabilitation. Revision TFR is mainly performed for periprosthetic infection and the severe femoral bone loss associated with aseptic revisions. Depending on the likelihood of attaining infection clearance, it may sometimes be advisable to proceed directly to hip disarticulation without attempting salvage of the TFR. Other reported complications of TFR include hip joint instability, limb length discrepancy, device failure, component loosening, patellar maltracking and delayed wound healing. Further research is needed to better characterize the long-term functional outcomes and complications associated with this complex procedure. | Deepak Ramanathan Marcelo BP Siqueira Alison K Klika Carlos A Higuera Wael K Barsoum Michael J Joyce | 2015 | World Journal of Orthopedics2015，6，11： | 6 |
| 2 | Acupuncture Treatment for Idiopathic Trigeminal Neuralgia:A Longitudinal Case-Control Double Blinded Study显示文摘Objective: To evaluate the treatment effect of acupuncture on patients with idiopathic trigeminal neuralgia(ITN) by case-control longitudinal blinded study. Methods: Sixty ITN patients and 30 healthy subjects were included. The ITN patients were randomly assigned to acupuncture group(15 cases), sham-acupuncture group(15 cases) and carbamazepine group(30 cases), respectively. Clinical orofacial evaluation(including pain intensity and medication doses), research diagnostic criteria for temporomandibular disorders(RDC/TMD) and Helkimo indexes(for functional evaluation of the masticatory system), and quantitative sensory testing for sensory thresholds(gustative, olfactory, cold, warm, touch, vibration and superficial and deep pain) were evaluated before treatment, immediately after treatment, and 6 months after treatment. Results: The mean pain intensity by the Visual Analogue Scale only decreased in the acupuncture group at the last evaluation(P=0.012). Patients in the sham-acupuncture group had an increase in carbamazepine doses according to the prescriptions(P<0.01). There was a reduction in secondary myofascial pain and mandibular limitations at the acupuncture and sham-acupuncture groups, however only the acupuncture group kept the changes after 6 months(P<0.01, P=0.023). There was a decrease in mechanical thresholds in the acupuncture group(tactile, P<0.01; vibration, P=0.027) and an increase in deep pain thresholds in both acupuncture and sham-acupuncture groups(P=0.013). Conclusion: Acupuncture can be an option in the treatment of ITN due to its analgesic effect in both ITN and secondary myofascial pain associated with it. | Michelle Cristina Ichida Mariana Zemuner Jorge Hosomi Hong Jin Pai Manoel Jacobsen Teixeira JoséTadeu Tesseroli de Siqueira Silvia R D T de Siqueira | 2017 | Chinese Journal of Integrative Medicine2017，23，11： | 6 |
| 3 | Role of negative pressure wound therapy in total hip and knee arthroplasty显示文摘Negative-pressure wound therapy(NPWT) has been a successful modality of wound management which is in widespread use in several surgical fields. The main mechanisms of action thought to play a role in enhancing wound healing and preventing surgical site infection are macrodeformation and microdeformation of the wound bed, fluid removal, and stabilization of the wound environment. Due to the devastating consequences of infection in the setting of joint arthroplasty, there has been some interest in the use of NPWT following total hip arthroplasty and total knee arthroplasty. However, there is still a scarcity of data reporting on the use of NPWT within this field and most studies are limited by small sample sizes, high variability of clinical settings and end-points. There is little evidence to support the use of NPWT as an adjunctive treatment for surgical wound drainage, and for this reason surgical intervention should not be delayed when indicated. The prophylactic use of NPWT after arthroplasty in patients that are at high risk for postoperative wound drainage appears to have the strongest clinical evidence. Several clinical trialsincluding single-use NPWT devices for this purpose are currently in progress and this may soon be incorporated in clinical guidelines as a mean to prevent periprosthetic joint infections. | Marcelo BP Siqueira Deepak Ramanathan Alison K Klika Carlos A Higuera Wael K Barsoum | 2016 | World Journal of Orthopedics2016，7，1： | 5 |
| 4 | Effects of high voltage electrical stimulation on the rate of pH decline,meat quality and color stability in chilled beef carcasses显示文摘Objective:To determine the effects of high voltage electrical stimulation(HVES,800 Voltage)on rapid decreases in pH values and improvements in meat quality.Methods:A total of SO beef carcasses were applied,divided into two groups,one as a control and another for HVES.Meat quality was evaluated based on M.hngissimus dorsi by examining pH and temperature leveb at 1,2,5,10 and 24 h,while color stability was examined seven days after slaughter.Results:HVES decreased the pH values of the meat and accelerated rigor mortis(P<0.05).HVES caused differences in instrumental color values compared with the control groups across the ageing period at 4℃.Conclusion:the HVES had positive effects on meat quality and color stability,in contrast to undesirable consumer preferences. | Ehsan Gharib Mombeni Manoochehr Gharib Mombeini Lucas Chaves Figueiredo Luciano Soares Jacintho Siqueira Debora Testoni Dias | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，9： | 4 |
| 5 | Search for naive human pluripotent stem cells显示文摘Normal mouse pluripotent stem cells were originally derived from the inner cell mass(ICM) of blastocysts and shown to be the in vitro equivalent of those pre-implantation embryonic cells, and thus were called embryonic stem cells(ESCs). More than a decade later, pluripotent cells were isolated from the ICM of human blastocysts. Despite being called human ESCs, these cells differ significantly from mouse ESCs, including different morphology and mechanisms of control of pluripotency, suggesting distinct embryonic origins of ESCs from the two species. Subsequently, mouse pluripotent stem cells were established from the ICMderived epiblast of post-implantation embryos. These mouse epiblast stem cells(Epi SCs) are morphological and epigenetically more similar to human ESCs. This raised the question of whether cells from the human ICM are in a more advanced differentiation stage than their murine counterpart, or whether the available culture conditions were not adequate to maintain those human cells in their in vivo state, leading to a transition into Epi SC-like cells in vitro. More recently, novel culture conditions allowed the conversion of human ESCs into mouse ESC-like cells called nave(or ground state) human ESCs, and the derivation of nave human ESCs from blastocysts. Here we will review the characteristics of each type of pluripotent stem cells, how(and whether) these relate to different stages of embryonic development, and discuss the potential implications of nave human ESCs in research and therapy. | Simone Aparecida Siqueira Fonseca Roberta Montero Costas Lygia Veiga Pereira | 2015 | World Journal of Stem Cells2015，7，3： | 2 |
| 6 | The columnar to equiaxed transition during solidification of Sn–Pb alloys显示文摘 | C.A. Siqueira N. Cheung A. Garcia | 2002 | Journal of Alloys and Compounds2002，，1： | 2 |
| 7 | The effect of endoscopic sphincterotomy on acute and chronic complications of biliary endoprostheses显示文摘 | Craig Margulies Eduardo Sampaio Siqueira William Bruce Silverman Xue Sen Lin John Anthony Martin Mordechai Rabinovitz Adam Slivka | 1999 | Gastrointestinal Endoscopy1999，，6： | 2 |
| 8 | The VILMA intelligent vehicle:an architectural design for cooperative control between driver and automated system显示文摘Intelligent autonomous vehicles have received a great degree of attention in recent years. Although the technology required for these vehicles is relatively advanced, the challenge is firstly to ensure that drivers can understand the capabilities and limitations of such systems and secondly to design a system that can handle the interaction between the driver and the automated intelligent system. In this study, we describe an approach using different strategies for an autonomous system and a driver to drive a vehicle cooperatively. The proposed strategies are referred to as cooperative planning and control and determine when and how the path projected by the autonomous system can be changed safely by the driver to a path that he wishes to follow. The first phase of the project is described,covering the design and implementation of an autonomous test vehicle. Experiments are carried out with a driver to test the cooperative planning and control concepts proposed here. | Olmer Garcia Giovani Bernardes Vitor Janito Vaqueiro Ferreira Pablo Siqueira Meirelles Arthurde Miranda Neto | 2018 | Journal of Modern Transportation2018，26，3： | 2 |
| 9 | Scoping review on vector-borne diseases in urban areas:transmission dynamics,vectorial capacity and co-infection显示文摘Background:Transmission dynamics,vectorial capacity,and co-infections have substantial impacts on vector-borne diseases(VBDs)affecting urban and suburban populations.Reviewing key factors can provide insight into priority research areas and offer suggestions for potential interventions.Main body:Through a scoping review,we identify knowledge gaps on transmission dynamics,vectorial capacity,and co-infections regarding VBDs in urban areas.Peer-reviewed and grey literature published between 2000 and 2016 was searched.We screened abstracts and full texts to select studies.Using an extraction grid,we retrieved general data,results,lessons learned and recommendations,future research avenues,and practice implications.We classified studies by VBD and country/continent and identified relevant knowledge gaps.Of 773 articles selected for full-text screening,50 were included in the review:23 based on research in the Americas,15 in Asia,10 in Africa,and one each in Europe and Australia.The largest body of evidence concerning VBD epidemiology in urban areas concerned dengue and malaria.Other arboviruses covered included chikungunya and West Nile virus,other parasitic diseases such as leishmaniasis and trypanosomiasis,and bacterial rickettsiosis and plague.Most articles retrieved in our review combined transmission dynamics and vectorial capacity;only two combined transmission dynamics and co-infection.The review identified significant knowledge gaps on the role of asymptomatic individuals,the effects of co-infection and other host factors,and the impacts of climatic,environmental,and socioeconomic factors on VBD transmission in urban areas.Limitations included the trade-off from narrowing the search strategy(missing out on classical modelling studies),a lack of studies on co-infections,most studies being only descriptive,and few offering concrete public health recommendations.More research is needed on transmission risk in homes and workplaces,given increasingly dynamic and mobile populations.The lack of studies on co-infection hampers monitoring of infections transmitted by the same vector.Conclusions:Strengthening VBD surveillance and control,particularly in asymptomatic cases and mobile populations,as well as using early warning tools to predict increasing transmission,were key strategies identified for public health policy and practice. | Marcus Eder Fanny Cortes Noemia Teixeira de Siqueira Filha Giovanny Vinicius Araujo de Franca Stephanie Degroote Cynthia Braga Valery Ridde Celina Maria Turchi Martelli | 2018 | Infectious Diseases of Poverty2018，7，1： | 2 |
| 10 | Mitochondria in colorectal cancer stem cells-a target in drug resistance显示文摘Colorectal cancer(CRC)is the third most diagnosed cancer and the second most deadly type of cancer worldwide.In late diagnosis,CRC can resist therapy regimens in which cancer stem cells(CSCs)are intimately related.CSCs are a subpopulation of tumor cells responsible for tumor initiation and maintenance,metastasis,and resistance to conventional treatments.In this scenario,colorectal cancer stem cells(CCSCs)are considered an important key for therapeutic failure and resistance.In its turn,mitochondria is an organelle involved in many mechanisms in cancer,including chemoresistance of cytotoxic drugs due to alterations in mitochondrial metabolism,apoptosis,dynamics,and mitophagy.Therefore,it is crucial to understand the mitochondrial role in CCSCs regarding CRC drug resistance.It has been shown that enhanced anti-apoptotic protein expression,mitophagy rate,and addiction to oxidative phosphorylation are the major strategies developed by CCSCs to avoid drug insults.Thus,new mitochondria-targeted drug approaches must be explored to mitigate CRC chemoresistance via the ablation of CCSCs. | Mateus de Almeida Rainho Priscyanne Barreto Siqueira Ísis Salviano Soares de Amorim Andre Luiz Mencalha Alessandra Alves Thole | 2023 | Cancer Drug Resistance2023，6，2： | 2 |
| 11 | Role of diet and nutrition in inflammatory bowel disease显示文摘Inflammatory bowel diseases(IBDs)are closely linked to nutrition.The latest research indicates that diet and nutrition are significantly involved in the etiopathogenesis of the disease,although their specific role throughout its clinical course still remains unclear.This study reviewed how diet and nutrition are associated with IBD development and management.Even though specific diets have been shown to bring about positive outcomes,there is currently no scientific consensus regarding an appropriate diet that would benefit all IBD patients.We suggest that individualized dietary recommendations are of the greatest importance and that diets should be planned to provide individual IBD patients with specific nutrient requirements while keeping all the clinical aspects of the patients in mind.Further research is clearly necessary to investigate nutritional factors involved in IBD development and,especially,to evaluate the applications of the diets during the course of the disease. | Marina Moreira de Castro Lívia Bitencourt Pascoal Karine Mariane Steigleder Beatriz Piatezzi Siqueira Ligiana Pires Corona Maria de Lourdes Setsuko Ayrizono Marciane Milanski Raquel Franco Leal | 2021 | World Journal of Experimental Medicine2021，11，1： | 2 |
| 12 | Transcatheter aortic valve replacement in elderly patients显示文摘大动脉的狭窄是最普通的本国的阀门疾病,影响直到 5% 老人口。外科的大动脉的阀门代替减少症状并且改进幸存,并且是在有征兆的严重大动脉的狭窄的病人的权威的治疗。尽管有经典外科的好结果,然而,风险显著地与合作病态在老病人被增加。Transcatheter 大动脉的阀门代替(TAVR ) 在 diseased 土著人以内允许一个修复术的心阀门的培植没有对开的心外科的需要的大动脉的阀门并且心肺绕过,把一种新治疗学的选择提供给老病人在高外科的风险或与禁止徵候考虑了到外科。迄今为止,几张 multicenter 注册表和使随机化的审判在那些病人证实了 TAVR 的安全和功效。在这章,我们在老病人考察背景和 TAVR 的临床的应用。 | Dimytri Siqueira Alexandre Abizaid Magaly Arrais J. Eduardo Sousa | 2012 | Journal of Geriatric Cardiology2012，9，2： | 2 |
| 13 | Effects of Hepatitis C virus on cardiovascular risk in infected patients: A comparative study显示文摘 | C.P.M.S. Oliveira C.R. Kappel E.R. Siqueira V.M.R. Lima J.T. Stefano M.T. Michalczuk S.S. Marini H.V. Barbeiro F.G. Soriano F.J. Carrilho L.M.M.B. Pereira M.R. Alvares-da-Silva | 2011 | International Journal of Cardiology2011，，： | 2 |
| 14 | Molecular analysis of the root canal microbiota associated with endodontic treatment failures显示文摘 | Sakamoto M Siqueira JF Jr R(o)(c)as IN | 2008 | Oral Microbiol Immunol2008，23，4： | 1 |
| 15 | Polymerase chain reaction-based analysis of microorganisms associated with failed endodontic treatment 显示文摘 | Siqueira JF Jr R6qas IN | 2004 | Oral Surg Oral Med Oral Pathol Oral Radiol En- dod2004，97，1： | 1 |
| 16 | Vesical metastasis of gastric adenocarcinoma显示文摘 | Antunes AA Siqueira TM Jr Falcao E | 2004 | Int Braz J Urol2004，30，5： | 1 |
| 17 | Intravitreal bevacizumab (Avastin) injection associated with regression of retinal neovascularization caused by sickle cell retinopathy 显示文摘 | Siqueira RC Costa RA Scott IU | 2006 | Acta Ophthalmol Scand2006，84，6： | 1 |
| 18 | Numerical simulation of flow interference be-tween two circular cylinders in tandem and side-by-side arrangements显示文摘 | Meneghini J R Saltara F Siqueira C L R Ferrari J A | 2001 | Journal of Fluids and Struc-tures2001，15，2： | 1 |
| 19 | Traumatic injuries of peripheral nerves: a review with emphasis on surgical indication 显示文摘 | Martins R S Bastos D Siqueira M G | 2013 | Arq Neuropsiquiatr2013，71，10： | 1 |
| 20 | Vesical metastasis of gastric ade- nocareinoma 显示文摘 | Antunes AA Siqueira TM Falcao E | 2004 | Int Braz J Urol2004，30，5： | 1 |
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