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| 1 | The fabrication of biomimetic biphasic CAN-PAC hydrogel with a seamless interfacial layer applied in osteochondral defect repair显示文摘Cartilage tissue engineering based on biomimetic scaffolds has become a rapidly developing strategy for repairing cartilage defects. In this study, a biphasic CAN-PAC hydrogel for osteochondral defect(OCD)regeneration was fabricated based on the density difference between the two layers via a thermally reactive,rapid cross-linking method. The upper hydrogel was cross-linked by CSMA and NIPAm, and the lower hydrogel was composed of PECDA, AAm and PEGDA. The interface between the two layers was first grafted by the physical cross-linking of calcium gluconate and alginate, followed by the chemical cross-linking of the carbon-carbon double bonds in the other components. The pore sizes of the upper and lower hydrogels were ~ 187.4 and ~ 112.6 μm, respectively. The moduli of the upper and lower hydrogels were ~ 0.065 and~ 0.261 MPa. This prepared bilayer hydrogel exhibited the characteristics of mimetic composition, mimetic structure and mimetic stiffness, which provided a microenvironment for sustaining cell attachment and viability. Meanwhile, the biodegradability and biocompatibility of the CAN-PAC hydrogel were examined in vivo. Furthermore, an osteochondral defect model was developed in rabbits, and the bilayer hydrogels were implanted into the defect. The regenerated tissues in the bilayer hydrogel group exhibited new translucent cartilage and repaired subchondral bone, indicating that the hydrogel can enhance the repair of osteochondral defects. | Jinfeng Liao Taoran Tian Sirong Shi Xueping Xie Quanquan Ma Guo Li Yunfeng Lin | 2017 | Bone Research2017，5，2： | 10 |
| 2 | Effects of tetrahedral framework nucleic acid/wogonin complexes on osteoarthritis显示文摘Osteoarthritis, a disorder characterized by articular cartilage deterioration, varying degrees of inflammation, and chondrocyte apoptosis, is the most common chronic joint disease. To slow or reverse its progression, inflammation should be inhibited, and chondrocyte proliferation should be promoted. Tetrahedral framework nucleic acids can be internalized by chondrocytes(even inflammatory chondrocytes) and can enhance their proliferation and migration. Wogonin, a naturally occurring flavonoid,suppresses oxidative stress and inhibits inflammation. In this study, tetrahedral framework nucleic acids were successfully selfassembled and used to load wogonin. We confirmed the effective formation of tetrahedral framework nucleic acid/wogonin complexes by dynamic light scattering, zeta potential analysis, transmission electron microscopy, and fluorescence spectrophotometry. Tetrahedral framework nucleic acids, wogonin, and especially tetrahedral framework nucleic acid/wogonin complexes effectively alleviated inflammation in vitro and in vivo and prevented cartilage destruction. In addition, these materials remarkably downregulated the expression of inflammatory mediators and matrix metalloproteinases, upregulated chondrogenic markers, and promoted tissue inhibitor of metalloproteinase 1 and B-cell lymphoma 2 expression. In vivo, after treatment with tetrahedral framework nucleic acid/wogonin complexes, the bone mineral density in regenerated tissues was much higher than that found in the untreated groups. Histologically, the complexes enhanced new tissue regeneration, significantly suppressed chondrocyte apoptosis, and promoted chondrogenic marker expression. They also inhibited cell apoptosis, increased chondrogenic marker expression, and suppressed the expression of inflammatory mediators in osteoarthritis. Therefore, we believe that tetrahedral framework nucleic acid/wogonin complexes can be used as an injectable form of therapy for osteoarthritis. | Sirong Shi Yang Chen Taoran Tian Songhang Li Shiyu Lin Yuxin Zhang Xiaoru Shao Tao Zhang Yunfeng Lin Xiaoxiao Cai | 2020 | Bone Research2020，8，1： | 9 |
| 3 | Tetrahedral Framework Nucleic Acid-Based Delivery of Resveratrol Alleviates Insulin Resistance:From Innate to Adaptive Immunity显示文摘Obesity-induced insulin resistance is the hallmark of metabolic syndrome,and chronic,low-grade tissue inflammation links obesity to insulin resistance through the activation of tissue-infiltrating immune cells.Current therapeutic approaches lack efficacy and immunomodulatory capacity.Thus,a new therapeutic approach is needed to prevent chronic inflammation and alleviate insulin resistance.Here,we synthesized a tetrahedral framework nucleic acid(tFNA)nanoparticle that carried resveratrol(RSV)to inhibit tissue inflammation and improve insulin sensitivity in obese mice.The prepared nanoparticles,namely tFNAs-RSV,possessed the characteristics of simple synthesis,stable properties,good water solubility,and superior biocompatibility.The tFNA-based delivery ameliorated the lability of RSV and enhanced its therapeutic efficacy.In high-fat diet(HFD)-fed mice,the administration of tFNAs-RSV ameliorated insulin resistance by alleviating inflammation status.tFNAs-RSV could reverse M1 phenotype macrophages in tissues to M2 phenotype macrophages.As for adaptive immunity,the prepared nanoparticles could repress the activation of Th1 and Th17 and promote Th2 and Treg,leading to the alleviation of insulin resistance.Furthermore,this study is the first to demonstrate that tFNAs,a nucleic acid material,possess immunomodulatory capacity.Collectively,our findings demonstrate that tFNAs-RSV alleviate insulin resistance and ameliorate inflammation in HFD mice,suggesting that nucleic acid materials or nucleic acid-based delivery systems may be a potential agent for the treatment of insulin resistance and obesity-related metabolic diseases. | Yanjing Li Shaojingya Gao Sirong Shi Dexuan Xiao Shuanglin Peng Yang Gao Ying Zhu Yunfeng Lin | 2021 | Nano-Micro Letters2021，13，6： | 4 |
| 4 | A Simple Method for Fabrication of Bionic Superhydrophobic Zinc Coating with Crater-like Structures on Steel Substrate显示文摘 | Hao Li Sirong Yu Xiangxiang Han Shanbao Zhang Yan Zhao | 2016 | Journal of Bionic Engineering2016，13，4： | 3 |
| 5 | Chromosomal-level genome of macadamia(Macadamia integrifolia)显示文摘Macadamia from the family Proteaceae is a plant native to Australia and has long been favoured by people for its crispy and high nutritional and medicinal value.Here,the genome of GUIRE 1(GR1),a highly heterozygous superior cultivar of macadamia nut,was sequenced and assembled using nanopore sequencing,and a 807-Mb genome(contig N50,1.9 Mb;scaffold N50,54.70 Mb)and 14 chromosomes were obtained.A total of 453 Mb(about 55.95%)repetitive sequences and 37,657 protein-coding genes were obtained by gene annotation and homologous protein comparison.Proteaceae diverged from Nelumbonaceae nearly 115.37 million years ago and from Rubiaceae about 140 million years ago.A genome-wide duplication(WGD)event occurred in macadamia 41 million years ago based on the WGD analysis.The functional enrichment analysis of M.integrifolia-specific gene families revealed their roles in signal transduction,protein phosphorylation,protein binding,and defense response.Here,a highly heterozygous genome of M.integrifolia was unlocked to provide a database for breeding and molecular mechanism research. | Chengcai Xia Sirong Jiang Qiujin Tan Wenquan Wang Long Zhao Chenji Zhang Yuting Bao Qi Liu Jianjia Xiao Ke Deng Miaohua He Pengliang An Wenlin Wang Meiling Zou Zhiqiang Xia | 2022 | Tropical Plants2022，1，1： | 3 |
| 6 | INFILTRATION KINETICS MODEL OF LIQUID METAL INTO A FIBROUS PREFORM IN CENTRIFUGAL ACCELERATING FIELD显示文摘The infiltration kinetics of the metal melt into a fibrous preform in centrifugal accelerating field is analyzed on the basis of Darcy’s law and the assumption that the fibrous preform is treated as 'bundle of capillaries' The critical rotating speed is analyzed with the established model The influences of the metal melt mass,the rotating speed of the equipment,the casting height, the original outer radius of the metal melt and the fibrous volume fraction in fibrous preform on infilatration are studied The results show that the critical rotating speed is dependent on critical pressure, casting height, metal melt mass and the character of fibrous preform With the increase in the metal melt mass, rotating speed of the equipment and original outer radius of the metal melt, or the decrease in casting height and fibrous volume fraction in fibrous of the metal melt,or the decrease in casting height and fibrous volume fraction in fibrous preform,infiltration of metal melt for fibrous preform becomes easier. | Zhang Xinping,Yu Sirong,He Zhenming (College of Materials Science and Engineering,Jilin University) | 2001 | Chinese Journal of Mechanical Engineering2001，14，4： | 2 |
| 7 | ELECTRO-THERMAL EFFECTS AND DEFORMATION RESPONSE OF CARBON FIBER MAT CEMENT BEAMS显示文摘A carbon fiber mat is a sheet composed of intercrossing short carbon fibers, which has more stable and lower electrical resistivity compared with dispersed short carbon fiber mixed in cement. Thereby carbon fiber mat cement could exhibit obvious electro-thermal effect. When electrified, the temperature of composite structures made up of cement mortar and carbon fiber mat will rise rapidly. If the temperature field is not uniform, temperature difference will cause structures to deform, which can be used to adjust the deformation of structures. The temperature field and deformation response driven by the electro-thermal effects of a type of carbon fiber mat cement beams are studied. Firstly, the temperature and deformation responses are studied using theories of thermal conduction and elasticity. Secondly, experimental results are given to verify the theoretical solution. These two parts lay the foundation for temperature and deformation adjustment. | Zhu Sirong Li Zhuoqiu Song Xianhui (Department of Engineering Structures and Mechanics,Wuhan University of Technology,Wuhan 430070,China) | 2003 | Acta Mechanica Solida Sinica2003，16，4： | 2 |
| 8 | Continuous Deformation Monitoring by Polymermatrix Carbon Fiber Sensitive Layer显示文摘Composite made of short-cut carbon fiber mat and vinyl ester resin was observed to be an effective sensor for tensile strain up to 6 000 με. Based on its strain sensitivity, a skin-like sensitive layer which can continuously cover the structural surface to sense strain in large area was developed. The sensitive layer was applied to continuously monitor the deformation of a simply supported beam. The result indicates that the fractional change in electrical resistance of the sensitive layer reversibly reflects the beam deformation in each section and describes the distribution of the average strain of the beam. The effect of temperature change on the monitoring was studied by monitoring tests conducted at different temperatures ranging from 20 to 80 ℃, which reveals temperature sensitivity in the sensitive layer and the temperature dependence of the piezoresistive behavior when the temperature exceeds 50 ℃. By the application of differential connection principle, a method for temperature compensation was established and the gauge factor for the monitoring was dramatically increased. This method was verified experimentally. | 郑华升 ZHU Sirong LI Zhuoqiu | 2016 | Journal of Wuhan University of Technology(Materials Science)2016，31，3： | 2 |
| 9 | Microstructure of fly ash cenosphere/AZ91D composite during solution treatment at 380-420℃显示文摘The fly ash cenosphere/AZ91D (FAC/AZ91D) composites containing 5 wt.% and 100 μm in size of fly-ash cenosphere particles were fabricated by means of the compcasting method.The microstructures of the as-cast samples and the effect of the solution treatment at 380℃,400℃,and 420℃ for 16 h on the microstructures of the samples were investigated by using of OM,SEM,XRD and EDS.The results showed that the cenospheres distributed homogeneously in the Mg alloy,and were almost filled with Mg alloy.The main interfacial phase between the cenospheres and AZ91D Mg alloy was identified as MgAl2O4 according to XRD,EDS and thermodynamic analysis.Mg2Si particles tended to be spheroidized via the solution treatment and the β phase (Mg17Al12) dissolved completely at 400℃. | Huang Zhiqiu Yu Sirong Li Muqin Liu Hongli | 2011 | China Foundry2011，8，1： | 1 |
| 10 | Temperature sensitivitiesof carbon fiber interface on epoxy 显示文摘 | Zheng Huasheng Zhu Sirong Li Zhuoqiu | 2010 | Journal of FunctionalMaterials2010，42，8： | 1 |
| 11 | Tribological properties of epoxy/rubber nanocomposites 显示文摘 | Yu Sirong Hu Haixia Ma Jun | 2008 | Tribology International2008，12，： | 1 |
| 12 | Effects of SEBS- g-MA on tribological behaviour of nylon 66/organoclay nanocomposites显示文摘 | Yu Sirong Yu Zhongzhen Mai Yiu-Wing | 2007 | Tribology2007，40，： | 1 |
| 13 | Development of laser-cladding layers containing nano-Al2O3 particles for wear-resistance materials 显示文摘 | Yu Sirong Liu Yan Ren Luquan | 2006 | Metallurgical and Materials Transactions2006，37，： | 1 |
| 14 | Deformation adjustment of concrete beams laminated with carbon fiber mats显示文摘 | Zhu Sirong Li Zhuoqiu Song Xianhui | 2007 | Construction and Building Materials2007，21，： | 1 |
| 15 | Analytical model of pie zoresistivity for strain sensing in carbon fiber poly mer matrix structural composite under flexure 显示文摘 | Zhu Sirong Chung D D L | 2007 | Carbon2007，45，： | 1 |
| 16 | A novel electrical resistance tomography system of carbon fiber smart layer for structural health monitoring显示文摘 | Zhang Xiaoyu Li Zhuoqiu Zhu Sirong | 2009 | IEEE International Conference on Intelligent Computing and Intelligent Systems2009，4，： | 1 |
| 17 | Tribological properties of epoxy/rubber nanocomposites显示文摘 | YU SIRONG HU HAIXIA MA JUN | 2008 | Tribology International2008，41，12： | 1 |
| 18 | Develop- ment of laser-cladding layers containing nano-Al2O3 particles for wear-resistance materials显示文摘 | YU Sirong LIU Yan REN Luquan | 2006 | Metallur- gical and Materials Transactions A:2006，37，12： | 1 |
| 19 | Tribological properties of epoxy/ rubber nanocomposites 显示文摘 | Yu Sirong Hu Haixia Ma Jun | 2008 | Tribology International2008，6，： | 1 |
| 20 | Reasonable compensation coefficient of maximum gradient in long railway tunnels显示文摘This paper deals with the theory and calculation methods for compensation of the gradient in railway tunnels through theoretical analysis,numerical calculation,and statistic regression methods.On the basis of the principle that the resultant force is zero,the formula of the maximum calculated gradient was derived for the freight and passenger line and high-speed passenger special line.The formula of aerodynamic drag in tunnel is provided using the domestic and foreign relevant experimental investigations,and revised with modern train and engineering parameters.A calculation model of aerodynamic drag when the train goes through a single-tracked tunnel was built.Finally,the concept of maximum calculated gradient was adopted to revise the formula for compensation of the gradient in railway tunnels. | Sirong YI Liangtao NIE Yanheng CHEN Fangfang QIN | 2011 | Journal of Modern Transportation2011，19，1： | 1 |
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