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| 1 | Nanomaterials and bone regeneration显示文摘The worldwide incidence of bone disorders and conditions has been increasing. Bone is a nanomaterials composed of organic(mainly collagen) and inorganic(mainly nano-hydroxyapatite) components, with a hierarchical structure ranging from nanoscale to macroscale. In consideration of the serious limitation in traditional therapies, nanomaterials provide some new strategy in bone regeneration. Nanostructured scaffolds provide a closer structural support approximation to native bone architecture for the cells and regulate cell proliferation, differentiation, and migration, which results in the formation of functional tissues. In this article,we focused on reviewing the classification and design of nanostructured materials and nanocarrier materials for bone regeneration, their cell interaction properties, and their application in bone tissue engineering and regeneration. Furthermore, some new challenges about the future research on the application of nanomaterials for bone regeneration are described in the conclusion and perspectives part. | Tao Gong Jing Xie Jinfeng Liao Tao Zhang Shiyu Lin Yunfeng Lin | 2015 | Bone Research2015，3，3： | 23 |
| 2 | Trends in geographical disparities for cervical cancer mortality in China from 1973 to 2013:a subnational spatio-temporal study显示文摘Objective: This study was designed to explore the time trends in geographical variations of cervical cancer mortality in China's Mainland over the period 1973 to 2013,to provide subnational spatio-temporal patterns for targeted promotion of human papillomavirus vaccine in China.Methods: Data were extracted from three national retrospective death surveys and cancer registry.The rate ratio(RR) was estimated for the aggregated data for seven geographical regions using generalized linear models to evaluate time trends in geographical disparities of cervical cancer mortality.Results: There was a significant decrease in cervical cancer mortality in China from 1973–1975 to 2004–2005,but leveled off thereafter to 2011–2013.Compared to the period 1973–1975 the RR for the three last time periods were 0.33 [95% confidence interval(95% CI): 0.30–0.37] for 1990–1992,0.21(95% CI: 0.19–0.24) for 2004–2005 and 0.24(95% CI: 0.22–0.26) for 2011–2013.Females living in the Northwest China and Central China have a high risk of mortality from cervical cancer compared to the nationwide,with the RR being 2.09(95% CI:1.83–2.38) and 1.26(95% CI: 1.11–1.44) respectively,while the RRs for South China,Northeast China and Southwest China were below 1.00,indicating the lower death risk.Despite the mortality rate had increased slightly from 2004 to 2013,there was an encouraging sign that the geographical disparities in cervical cancer mortality had gradually narrowed over time across China.Conclusions: Although cervical cancer mortality in China has reduced to very low levels,the high risk of cervical cancer in Northwest China and Central China is still noteworthy.Public health policies including the promotion of vaccine should be targeted to further reduction of geographical disparities in cervical cancer mortality. | Changfa Xia Chao Ding Rongshou Zheng Siwei Zhang Hongmei Zeng Jinfeng Wang Yilan Liao Ningxu Zhang Zhixun Yang Wanqing Chen | 2017 | Chinese Journal of Cancer Research2017，29，6： | 13 |
| 3 | The design,mechanism and biomedical application of self-healing hydrogels显示文摘Hydrogels are promising materials with outstanding characteristics such as tunable and reversible physical/chemical properties,stimuli-responsiveness,biomimetic,and biocompatibility.However,the structural and functional integrity of the hydrogels can be compromised by external mechanical forces or chemical erosion when used,especially in sophisticated in vivo environment.To address this problem,self-healing hydrogels which possess the intrinsic ability of self-repair have been developed to adapt to destructive factors.In this review,we focused on the current advances made in self-healing hydrogels.First,the testing methods for self-healing hydrogels were summarized.Then,we looked into the designing strategies of self-healing hydrogels and illustrated the self-healing mechanism.What's more,the biomedical application of self-healing hydrogels in vivo was discussed. | Qiwen Li Chenlu Liu Junru Wen Yongzhi Wu Yue Shan Jinfeng Liao | 2017 | Chinese Chemical Letters2017，28，9： | 11 |
| 4 | The fabrication of biomimetic biphasic CAN-PAC hydrogel with a seamless interfacial layer applied in osteochondral defect repair显示文摘Cartilage tissue engineering based on biomimetic scaffolds has become a rapidly developing strategy for repairing cartilage defects. In this study, a biphasic CAN-PAC hydrogel for osteochondral defect(OCD)regeneration was fabricated based on the density difference between the two layers via a thermally reactive,rapid cross-linking method. The upper hydrogel was cross-linked by CSMA and NIPAm, and the lower hydrogel was composed of PECDA, AAm and PEGDA. The interface between the two layers was first grafted by the physical cross-linking of calcium gluconate and alginate, followed by the chemical cross-linking of the carbon-carbon double bonds in the other components. The pore sizes of the upper and lower hydrogels were ~ 187.4 and ~ 112.6 μm, respectively. The moduli of the upper and lower hydrogels were ~ 0.065 and~ 0.261 MPa. This prepared bilayer hydrogel exhibited the characteristics of mimetic composition, mimetic structure and mimetic stiffness, which provided a microenvironment for sustaining cell attachment and viability. Meanwhile, the biodegradability and biocompatibility of the CAN-PAC hydrogel were examined in vivo. Furthermore, an osteochondral defect model was developed in rabbits, and the bilayer hydrogels were implanted into the defect. The regenerated tissues in the bilayer hydrogel group exhibited new translucent cartilage and repaired subchondral bone, indicating that the hydrogel can enhance the repair of osteochondral defects. | Jinfeng Liao Taoran Tian Sirong Shi Xueping Xie Quanquan Ma Guo Li Yunfeng Lin | 2017 | Bone Research2017，5，2： | 10 |
| 5 | Biomaterial-based strategies for maxillofacial tumour therapy and bone defect regeneration显示文摘Issues caused by maxillofacial tumours involve not only dealing with tumours but also repairing jaw bone defects.In traditional tumour therapy,the systemic toxicity of chemotherapeutic drugs,invasive surgical resection,intractable tumour recurrence,and metastasis are major threats to the patients’lives in the clinic.Fortunately,biomaterial-based intervention can improve the efficiency of tumour treatment and decrease the possibility of recurrence and metastasis,suggesting new promising antitumour therapies.In addition,maxillofacial bone tissue defects caused by tumours and their treatment can negatively affect the physiological and psychological health of patients,and investment in treatment can result in a multitude of burdens to society.Biomaterials are promising options because they have good biocompatibility and bioactive properties for stimulation of bone regeneration.More interestingly,an integrated material regimen that combines tumour therapy with bone repair is a promising treatment option.Herein,we summarized traditional and biomaterial-mediated maxillofacial tumour treatments and analysed biomaterials for bone defect repair.Furthermore,we proposed a promising and superior design of dual-functional biomaterials for simultaneous tumour therapy and bone regeneration to provide a new strategy for managing maxillofacial tumours and improve the quality of life of patients in the future. | Bowen Tan Quan Tang Yongjin Zhong Yali Wei Linfeng He Yanting Wu Jiabao Wu Jinfeng Liao | 2021 | International Journal of Oral Science2021，13，1： | 9 |
| 6 | Sedimentary Characteristics and Model of Gravity Flow Depositional System for the First Member of Upper Miocene Huangliu Formation in Dongfang Area, Yinggehai Basin, Northwestern South China Sea显示文摘The gravity flow deposit were mainly developed in the lowstand systems tract(LST) of the first member of Upper Miocene Huangliu Formation(Ehl1) in Dongfang area, Yinggehai Basin, has become a valuable target for gas exploration and production. The gravity flow sedimentary characteristics of lithofacies associations, sedimentary texture, seismic facies and logging facies were described in detail on the basis of integrated analysis of cores, logging and seismic data. The sedimentary microfacies types composed of neritic sandbar, continental shelf mud, main channel, bifurcated or cross-cutting distributary channel, overspill, and natural levee are revealed under the constraint of high resolution sequence stratigraphic framework in the Ehl1. The gravity flow deposit system in the LST is divided into three evolution stages corresponding to periods of three parasequence sets. The gravity flow deposit was induced in the early LST, expanded rapidly in the middle LST and decreased slightly in the late LST. But its developing scale decreased sharply in the transgression systems tract(TST) and finally vanished in the highstand systems tract(HST). This spatial evolution rule is constrained by the integrated function of sediments supply of the Vietnam Blue River in the LST, the development of local gradient change in sea floor(micro-topography, i.e., flexure slope break), and the fall in relative sea level. On the basics of the deep study of the coupling relationship among the three main control factors, the sedimentary model is established as an optimal component of 'source-channel-sink' for shallow marine turbidite submarine fan. | Ming Sun Hua Wang Jihua Liao Huajun Gan Jun Xiao Jinfeng Ren Shu'e Zhao | 2014 | Journal of Earth Science2014，25，3： | 9 |
| 7 | Gold nanorods and nanohydroxyapatite hybrid hydrogel for preventing bone tumor recurrence via postoperative photothermal therapy and bone regeneration promotion显示文摘Osteosarcoma is a malignant bone tumor,which often occurs in adolescents.However,surgical resection usually fails to completely remove the tumor clinically,which has been the main cause of postoperative recurrence and metastasis,resulting in the high death rate of patients.At the same time,osteosarcoma invades a large area of the bone defect,which cannot be self-repaired and seriously affects the life quality of the patients.Herein,a bifunctional methacrylated gelatin/methacrylated chondroitin sulfate hydrogel hybrid gold nanorods(GNRs)and nanohydroxyapatite(nHA),which possessed excellent photothermal effect,was constructed to eradicate residual tumor after surgery and bone regeneration.In vitro,K7M2wt cells(a mouse bone tumor cell line)can be efficiently eradicated by photothermal therapy of the hybrid hydrogel.Meanwhile,the hydrogel mimics the extracellular matrix to promote proliferation and osteogenic differentiation of mesenchymal stem cells.The GNRs/nHA hybrid hydrogel was capable of photothermal treatment of postoperative tumors and bone defect repair in a mice model of tibia osteosarcoma.Therefore,the hybrid hydrogel possesses dual functions of tumor therapy and bone regeneration,which shows great potential in curing bone tumors and provides a new hope for tumor-related bone complex disease. | Jinfeng Liao Kun Shi Yanpeng Jia Yanting Wu Zhiyong Qian | 2021 | Bioactive Materials2021，6，8： | 3 |
| 8 | Intermolecular electronic coupling of 9-methyl-9H-dibenzo[a,c]carbazole for strong emission in aggregated state by substituent effect显示文摘Bright emission of organic luminogens at aggregated state has attracted increasing attention for their potential applications in opto-electronic devices and bio-/chemo-sensors.In this article,upon the introduction of different substituents(Br,Ph and TPh)to the large conjugated core of 9-methyl-9H-dibenzo[a,c]carbazole(DBC)moiety,the resultant luminogens demonstrated PL quantum yields in solid state ranging from 4.81%to 47.39%.Through the systematic investigation of molecular packing,together with theory calculation,the strong intermolecular electronic coupling in the dimers is proved as the main factor to the bright emission in the solid state.The results afforded a new avenue to investigate the intrinsic relationship among the molecular structures,packing modes and emission properties. | Fan Liu Qiuyan Liao Jinfeng Wang Yanbing Gong Qianxi Dang Weidong Ling Mengmeng Han Qianqian Li Zhen Li | 2020 | Science China Chemistry2020，63，10： | 2 |
| 9 | Review of a new bone tumor therapy strategy based on bifunctional biomaterials显示文摘Bone tumors,especially those in osteosarcoma,usually occur in adolescents.The standard clinical treatment includes chemotherapy,surgical therapy,and radiation therapy.Unfortunately,surgical resection often fails to completely remove the tumor,which is the main cause of postoperative recurrence and metastasis,resulting in a high mortality rate.Moreover,bone tumors often invade large areas of bone,which cannot repair itself,and causes a serious effect on the quality of life of patients.Thus,bone tumor therapy and bone regeneration are challenging in the clinic.Herein,this review presents the recent developments in bifunctional biomaterials to achieve a new strategy for bone tumor therapy.The selected bifunctional materials include 3D-printed scaffolds,nano/microparticle-containing scaffolds,hydrogels,and bone-targeting nanomaterials.Numerous related studies on bifunctional biomaterials combining tumor photothermal therapy with enhanced bone regeneration were reviewed.Finally,a perspective on the future development of biomaterials for tumor therapy and bone tissue engineering is discussed.This review will provide a useful reference for bone tumor-related disease and the field of complex diseases to combine tumor therapy and tissue engineering. | Jinfeng Liao Ruxia Han Yongzhi Wu Zhiyong Qian | 2021 | Bone Research2021，9，2： | 2 |
| 10 | Hydrogel platform with tunable stiffness based on magnetic nanoparticles cross-linked GelMA for cartilage regeneration and its intrinsic biomechanism显示文摘Cartilage injury affects numerous individuals,but the efficient repair of damaged cartilage is still a problem in clinic.Hydrogel is a potent scaffold candidate for tissue regeneration,but it remains a big challenge to improve its mechanical property and figure out the interaction of chondrocytes and stiffness.Herein,a novel hybrid hydrogel with tunable stiffness was fabricated based on methacrylated gelatin(GelMA)and iron oxide nanoparticles(Fe_(2)O_(3))through chemical bonding.The stiffness of Fe_(2)O_(3)/GelMA hybrid hydrogel was controlled by adjusting the concentration of magnetic nanoparticles.The hydrogel platform with tunable stiffness modulated its cellular properties including cell morphology,microfilaments and Young’s modulus of chondrocytes.Interestingly,Fe_(2)O_(3)/GelMA hybrid hydrogel promoted oxidative phosphorylation of mitochondria and facilitated catabolism of lipids in chondrocytes.As a result,more ATP and metabolic materials generated for cellular physiological activities and organelle component replacements in hybrid hydrogel group compared to pure GelMA hydrogel.Furthermore,implantation of Fe_(2)O_(3)/GelMA hybrid hydrogel in the cartilage defect rat model verified its remodeling potential.This study provides a deep understanding of the bio-mechanism of Fe_(2)O_(3)/GelMA hybrid hydrogel interaction with chondrocytes and indicates the hydrogel platform for further application in tissue engineering. | Chenchen Zhou Chunli Wang Kang Xu Zhixing Niu Shujuan Zou Demao Zhang Zhiyong Qian Jinfeng Liao Jing Xie | 2023 | Bioactive Materials2023，，7： | 1 |
| 11 | Application of GIS-Based Spatial Filtering Method for Neural Tube Defects Disease Mapping显示文摘This study is to assess the prevalence rates spatial pattern of neural tube defects with geographic information system and spatial filtering technique. A total of 80 infants who diagnosed from neural tube defects in the area being studied between 1998 and 2001 were analyzed. Firstly, the geographic information system (GIS) software ArcGIS was used to map the crude prevalence rates. Secondly, the data were smoothed by the method of spatial filtering. We evaluated that the effect of changes in spa-tial filtering radius size was assessed by creating maps based on various filtering radius sizes. The 3 miles or larger filtering radius gives better sec-tion variability than the 2 and 2.5 miles or smaller ones. The maps pro-duced by the spatial filtering technique indicate that prevalence rates in the villages in the southeastern region are to produce higher prevalence than that in the other regions. The smoothed maps based on Heshun County display a more adequate data representation than the raw prevalence rate map. | CHI Wenxue WANG Jinfeng LI Xinhu ZHENG Xiaoying LIAO Yilan | 2007 | Wuhan University Journal of Natural Sciences2007，12，6： | 1 |
| 12 | Controlled release of cisplatin from pH-thermal dual responsive nano- gels显示文摘 | Peng Jinrong Qi Tingting Liao Jinfeng | 2013 | Biomaterials2013，34，34： | 1 |
| 13 | Quantum switch for single-photon transport in a coupled superconducting transmis- sion line resonator array显示文摘 | Liao Jieqiao Huang Jinfeng Liu Yuxi | 2009 | Phys Rev A2009，80，01： | 1 |
| 14 | Functional expression of P2X family receptors in macrophages is affected by microenvironment in mouse T cell acute lymphoblastic leukemia显示文摘 | Shayan Chen Wenli Feng Xiao Yang Wanzhu Yang Yongxin Ru Jinfeng Liao Lina Wang Yongmin Lin Qian Ren Guoguang Zheng | 2014 | Biochemical and Biophysical Research Communications2014，，4： | 1 |
| 15 | Biological evaluation of 2-methylpyrimidine derivatives as active pan Bcr-Abl inhibitors显示文摘We designed a series of 2-methylpyrimidine derivatives as new BCR-ABL inhibitors using scaffold-hopping strategy.These synthetic compounds exhibited significant inhibition against a broad spectrum of Bcr-Abl mutants including the gatekeeper T315I mutant.Compound 7u showed very potent kinase inhibitory activities against Bcr-Abl WT,Bcr-Abl E255K,Bcr-Abl Q252H,Bcr-Abl G250E and Bcr-Abl T315I,with IC50 values of 0.13 nM,0.17 nM,0.24 nM,0.19 nM and 0.65μM,respectively.This compound also displayed anti-proliferation activity against K562 cell line with an IC50 value of 1.1 nM,thus representing a new lead for further optimization. | ZOU DingBiao QIU YaTao TU ZhengChao LIAO ChenZhong LUO JinFeng MENG QingQing YAO RiSheng LI Zheng JIANG Sheng | 2014 | Science China Chemistry2014，57，6： | 0 |
| 16 | Multiple Dirac points including potential spin-orbit Dirac points in nonsymmorphic HfGe0.92Te显示文摘The search for new materials with Dirac points has been a fascinating subject of condensed matter physics.Here we first report the growth and band structure of HfGe_(0.92)Te single crystals featuring three different types of Dirac points.HfGe_(0.92)Te crystallizes in a nonsymmorphic tetragonal space group P4/nmm(No.129),having a square Ge-atom plane with vacancies of about 8%.Using angle-resolved photoemission spectroscopy(ARPES),the Dirac nodal line composed of conventional Dirac points vulnerable to spin-orbit coupling(SOC)is observed,accompanied by robust Dirac points protected by the nonsymmorphic symmetry against SOC and vacancies.In particular,spin-orbit Dirac points(SDPs)originating from the surface formed under significant SOC could exist based on ARPES and calculations.Quasi-two-dimensional(quasi-2D)characteristics are confirmed by angular-resolved magnetoresistance.HfGe_(0.92)Te bulk crystals can be easily exfoliated to flakes with a thickness of approximately 5 nm for the quasi-2D nature.Thus,HfGe_(0.92)Te provides a good platform to explore exotic topological phases or topological properties with three different types of Dirac points,which is a potential candidate to achieve novel 2D SDPs. | Long Chen Liqin Zhou Ying Zhou Chen Liu Zhongnan Guo Ke Liao Shunye Gao Wenhui Fan Jinfeng Xu Yuxuan Guo Jia'ou Wang Tian Qian Hongming Weng Gang Wang | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，1： | 0 |
| 17 | Accelerated Evolution of H7N9 Subtype Influenza Virus under Vaccination Pressure显示文摘No avian H7 N9 outbreaks have occurred since the introduction of H7 N9 inactivated vaccine in the fall of 2017.However,H7 N9 is still prevalent in poultry.To surveil the prevalence,genetic characteristics,and antigenic changes of H7 N9,over7000 oropharyngeal and cloaca swab specimens were collected from live poultry markets and farms in 15 provinces of China from 2017 to 2019.A total of 85 influenza virus subtype H7 N9 strains were isolated and 20 representative strains were selected for genetic analysis and antigenicity evaluation.Results indicated the decreased prevalence of low-pathogenic H7 N9 strains while highly-pathogenic H7 N9 strains became dominated since the introduction of vaccine.Phylogenetic analysis showed that strains from 2019 formed an independent small branch and were genetically distant to strains isolated in 2013–2018.Analysis of key amino acid sites showed that the virus strains may adapt to the host environment evolutionally through mutation.Our analysis predicted additional potential glycosylation sites for HA and NA genes in the 2019 strains.Sequence analysis of HA gene in strains isolated from 2018 to 2019 showed that there were an increased nucleotide substitution rate and an increased mutation rate in the first and second nucleotides of coding codons within the open reading frame.The hemagglutination inhibition(HI)assay showed that H7-Re1 and H7-Re2 exhibited a lower HI titer for isolates from 2019,while H7-Re3 and r LN79 showed a high HI titer.The protective effect of the vaccine decreased after15 months of use.Overall,under vaccination pressure,the evolution of influenza virus subtype H7 N9 has accelerated. | Yifan Wu Jingkai Hu Xuanjiang Jin Xiao Li Jinfeng Wang Mengmeng Zhang Jianglin Chen Shumin Xie Wenbao Qi Ming Liao Weixin Jia | 2021 | Virologica Sinica2021，36，5： | 0 |
| 18 | A potential flower-like coating consisting of calcium-phosphate nanosheets on titanium surface显示文摘Titanium and its alloys have been widely used as implant materials in bio-medicine.Additionally,surface modification has been utilized to improve the chemical and morphological properties of materials.More specifically,biocoating,especially the calcium-phosphate nano-coating,has been widely used in the research field.In this study,a novel calcium-phosphate nanoflower coating was performed on the titanium surface by a simple approach.This study indicated that the novel calcium-phosphate flower-like coating consisting of calcium-phosphate nanosheets had high surface area,low cytotoxicity as well as promising cell affinity.Hence it could be a potential alternative modification method for titanium. | Quanquan Ma Jinfeng Liao Taoran Tian Qi Zhang Xiaoxiao Cai | 2017 | Chinese Chemical Letters2017，28，9： | 0 |
| 19 | Wideband Direction-of-Arrival Estimation Based on Deep Learning显示文摘The performance of traditional high-resolution direction-of-arrival(DOA)estimation methods is sensitive to the inaccurate knowledge on prior information,including the position of ar-ray elements,array gain and phase,and the mutual coupling between the array elements.Learning-based methods are data-driven and are expected to perform better than their model-based counter-parts,since they are insensitive to the array imperfections.This paper presents a learning-based method for DOA estimation of multiple wideband far-field sources.The processing procedure mainly includes two steps.First,a beamspace preprocessing structure which has the property of fre-quency invariant is applied to the array outputs to perform focusing over a wide bandwidth.In the second step,a hierarchical deep neural network is employed to achieve classification.Different from neural networks which are trained through a huge data set containing different angle combinations,our deep neural network can achieve DOA estimation of multiple sources with a small data set,since the classifiers can be trained in different small subregions.Simulation results demonstrate that the proposed method performs well both in generalization and imperfections adaptation. | Liya Xu Yi Ma Jinfeng Zhang Bin Liao | 2021 | Journal of Beijing Institute of Technology2021，30，4： | 0 |
| 20 | Probing the color structure of the perfect QCD fluids via soft-hard-event-by-event azimuthal correlations显示文摘We develop a comprehensive dynamical framework, CIBJET, to calculate on an event-by-event basis the dependence of correlations between soft(p_T<2 GeV) and hard(p_T>10 GeV) azimuthal flow angle harmonics on the color composition of near-perfect QCD fluids produced in high energy nuclear collisions at RHIC and LHC. CIBJET combines consistently predictions of event-by-event VISHNU2+1 viscous hydrodynamic fluid fields with CUJET3.1 predictions of event-by-event jet quenching. We find that recent correlation data favor a temperature dependent color composition including bleached chromo-electric q(T) + g(T) components and an emergent chromo-magnetic degrees of freedom m(T) consistent with non-perturbative lattice QCD information in the confinement/deconfinement temperature range. | Shuzhe Shi Jinfeng Liao Miklos Gyulassy | 2018 | Chinese Physics C2018，42，10： | 0 |
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