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| 1 | 卫生技术评估:全球经验综述显示文摘一、《健康价值》特刊中的卫生技术评估综述近来,在药物发展和卫生管理领域中,卫生技术评估(Health Technology Assessment,HTA)引发了较多的关注和争议。这是由于HTA带来的高风险收益引起了人们的兴趣。对HTA结果的理解很大程度上取决于各主体的视角。评论家认为,目前HTA的应用还仅限于对新医疗技术进行评估以设置其使用上的限制,但更应提倡运用HTA技术达到促进资源的有效配置及改善群体健康的目的。 | John C.O'Donnell PhD Sissi V.Pham PharmD Chris L.Pashos DavidW.Miller Marilyn Dix Smith BPharm 刘庆婧 吴晶 | 2010 | 中国药物经济学2010，，1： | 4 |
| 2 | On the friction and adhesion hysteresis between polymer brushes attached to curved surfaces: Rate and solvation effects显示文摘Computer simulations of friction between polymer brushes are usually simplified compared to real systems in terms of solvents and geometry.In most simulations,the solvent is only implicit with infinite compressibility and zero inertia.In addition,the model geometries are parallel walls rather than curved or rough as in reality.In this work,we study the effects of these approximations and more generally the relevance of solvation on dissipation in polymer-brush systems by comparing simulations based on different solvation schemes.We find that the rate dependence of the energy loss during the collision of brush-bearing asperities can be different for explicit and implicit solvent.Moreover,the non-Newtonian rate dependences differ noticeably between normal and transverse motion,i.e.,between head-on and off-center asperity collisions.Lastly,when the two opposing brushes are made immiscible,the friction is dramatically reduced compared to an undersaturated miscible polymer-brush system,irrespective of the sliding direction. | Sissi de BEER G.DjuidjéKENMOÉ Martin H.MÜSER | 2015 | Friction2015，3，2： | 2 |
| 3 | Amide bond direction modu-lates G-quadruplex recognition and telomerase inhibition by 2 ,6and 2 ,7 bis-substituted anthracenedione derivatives 显示文摘 | Zagotto G Sissi C Moro S | 2008 | BioorgMed Chem2008，16，1： | 1 |
| 4 | DNA binding by a new metallointercalator that contains a proflavine group bearing a hanging chelating unit显示文摘 | Bazzicalupi C Bencini A Bianchi A Biver T Boggioni A Bonacchi A Danesi A Giorgi C Gratteri P Ingrán A.M Secco F Sissi C Valtancoli B Venturini M | | 0，，1： | 1 |
| 5 | 查看详情显示文摘 | Bazzicalupi C Chioccioli M Sissi C Porcù E Bonaccini C Pivetta C Bencini A Giorgi C Valtancoli B. Melani F | | 0，，： | 1 |
| 6 | Antitumor aza-anthra- pyrazoles:biophysical and biochemical studies on 8- and 9-aza regioisomers 显示文摘 | Sissi C Leo E Moro S | 2004 | Biochem Pharmacol2004，67，4： | 1 |
| 7 | DNA binding by a new metallointercalator that contains a proflavine group bearing a hanging chelating unit显示文摘 | Bazzicalupi C Bencini A Bianchi A Biver T Boggioni A Bonacchi S Danesi A Giorgi C Gratteri P Ingrain A.M Secco F Sissi C Valtancoli B Venturini M | | 0，，1： | 1 |
| 8 | Enur esis显示文摘 | Sissie EC | 2002 | Southern Med J2002，95，2： | 1 |
| 9 | DNA-intercative anticancer aza-anthrapyrazole: biophysical and biochemical studies relevant to the mechanism of action显示文摘 | Moro S Richter S | 2000 | Mol Pharmaco2000，59，： | 1 |
| 10 | Physicochemical properties,cytotoxic activity and topoisomerase Ⅱ inhibition of 2,3-diaza-anthracenediones显示文摘 | Palumbo M Sissi C | 1997 | Biochem Pharmacol1997，53，： | 1 |
| 11 | DNA-binding preference of bisantrenea nalogues:relevance to the sequence specificity of drug-medlated topoisomerase Ⅱ poisoning显示文摘 | Sissi C Bolgan L Moro S | 1998 | Mol Pharmacol1998，54，6： | 1 |
| 12 | The Retained Surgical Sponge显示文摘 | C. William Kaiser Sissie Friedman Kathleen Pfeifer Spurling Timothy Slowick Holly A. Kaiser | 1996 | Annals of Surgery1996，，1： | 1 |
| 13 | Cell surface targeting accounts for the difference in iodide uptake activity between human Na^+/1-symporter and rat Na^+/1-symporter显示文摘 | Zhang Z Liu YY Sissy M | 2005 | The Journal of clinical endocrinology and metabelism2005，90，11： | 1 |
| 14 | Enuresis显示文摘 | SiSSie EC | 2002 | Southern Medical Journal2002，89，： | 1 |
| 15 | Polyphenolic components of Rhus coriaria leaves显示文摘 | SISSI E I ISHAK M S | 1972 | Planta Med1972，21，1： | 1 |
| 16 | DNA-binding preference of bisantrene analogues: relevance to the sequence specificity of drug-mediated topoisomerase Ⅱ poisoning 显示文摘 | Sissi C Bolgan L Moro S | 1998 | Mol Pharmacol1998，54，6： | 1 |
| 17 | Physicochemical properties, cytotoxic activity and topoisomerase n inhibition of 2, 3-diaza-anthracenediones 显示文摘 | de ISABELLA P PALUMBO M SISSI C | 1997 | Biochem Pharmacol1997，53，2： | 1 |
| 18 | DNA-intercative anticancer aza-anthrapyrazole , biophysical and biochemical studies relevant to the mechanism of ac- tion 显示文摘 | SISSI C MORO S RICHTER S | 2000 | Mol Pharmacol2000，59，1： | 1 |
| 19 | Anthracyclines: Recent developments in their separation and quantitation 显示文摘 | Gatto B Moro S Sissi C Palumbo M | 2001 | J Chromatogr B Biomed Sci Appl2001，，12： | 1 |
| 20 | Modeling and biological investigations of an unusual behavior of novel synthesized acridine-based polyamine ligands in the binding of double helix and G-quadruplex DNA显示文摘 | Bazziealupi C Chioceioli M Sissi C | 2010 | ChemMedChem2010，5，： | 1 |
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