| 1 | Genesis of the Changba–Lijiagou Giant Pb-Zn Deposit, West Qinling, Central China: Constraints from S-Pb-C-O isotopes显示文摘The extensive Changba-Lijiagou Pb-Zn deposit is located in the north of the Xihe–Chengxian ore cluster in West Qinling. The ore bodies are mainly hosted in the marble, dolomitic marble and biotite-calcite-quartz schist of the Middle Devonian Anjiacha Formation, and are structurally controlled by the fault and anticline. The ore-forming process can be divided into three main stages, based on field geological features and mineral assemblages. The mineral assemblages of hydrothermal stage I are pale-yellow coarse grain, low Fe sphalerite, pyrite with pits, barite and biotite. The mineral assemblages of hydrothermal stage II are black-brown cryptocrystalline, high Fe shalerite, pyrite without pits, marcasite or arsenopyrite replace the pyrite with pits, K-feldspar. The features of hydrothermal stage III are calcite-quartz-sulfide vein cutting the laminated, banded ore body. Forty-two sulfur isotope analyses, twenty-five lead isotope analyses and nineteen carbon and oxygen isotope analyses were determined on sphalerite, pyrite, galena and calcite. The δ34 S values of stage I(20.3 to 29.0‰) are consistent with the δ34 S of sulfate(barite) in the stratum. Combined with geological feature, inclusion characteristics and EPMA data, we propose that TSR has played a key role in the formation of the sulfides in stage I. The δ34 S values of stage II sphalerite and pyrite(15.1 to 23.0‰) are between sulfides in the host rock, magmatic sulfur and the sulfate(barite) in the stratum. This result suggests that multiple S reservoirs were the sources for S2-in stage II. The δ34 S values of stage III(13.1 to 22‰) combined with the structure of the geological and mineral features suggest a magmatic hydrothermal origin of the mineralization. The lead isotope compositions of the sulfides have 206 Pb/204 Pb ranging from 17.9480 to 17.9782, 207 Pb/204 Pb ranging from 15.611 to 15.622, and 208 Pb/204 Pb ranging from 38.1368 to 38.1691 in the three ore-forming stages. The narrow and symmetric distributions of the lead isotope values reflect homogenization of granite and mantle sources before the Pb-Zn mineralization. The δ13 CPDB and δ18 OSMOW values of stage I range from-0.1 to 2.4‰ and from 18.8 to 21.7‰. The values and inclusion data indicate that the source of fluids in stage I was the dissolution of marine carbonate. The δ13 CPDB and δ18 OSMOW values of stage II range from-4 to 1‰ and from 12.3 to 20.3‰, suggesting multiple C-O reservoirs in the Changba deposit and the addition of mantle-source fluid to the system. The values in stage III are-3.1‰ and 19.7‰, respectively. We infer that the process of mineralization involved evaporitic salt and sedimentary organic-bearing units interacting through thermochemical sulfate reduction through the isotopic, mineralogy and inclusion evidences. Subsequently, the geology feature, mineral assemblages, EPMA data and isotopic values support the conclusion that the ore-forming hydrothermal fluids were mixed with magmatic hydrothermal fluids and forming the massive dark sphalerite, then yielding the calcite-quartz-sulfide vein ore type at the last stage. The genesis of this ore deposit was epigenetic rather than the previously-proposed sedimentary-exhalative(SEDEX) type. | WEI Ran WANG Yitian MAO Jingwen HU Qiaoqing QIN Siting LIU Shengyou YE Dejin YUAN Qunhu DOU Ping | 2020 | Acta Geologica Sinica(English Edition)2020，94，4： | 4 |
| 2 | RIP1/3-dependent programmed necrosis induces intestinal injuryin septic rats显示文摘The regulation of various types of cell death may help to restore the normal physiological function of cells and play a protective role in sepsis.In the current study,we explore the role of programmed cell necrosis in sepsis and the underlying mechanisms.The septic rat model is established by Cecal-ligation and perforation(CLP),and the in vitro model is established by LPS in IEC-6 cells.Our results demonstrate that receptor-interacting protein 1(RIP1)is significantly upregulated in the ileum of septic rats and LPS-treated IEC-6 cells at both the mRNA and protein levels.Nec-1,an inhibitor of RIP1,reduces the protein levels of RIP1,p-RIP3,and phosphorylated mixed-lineage kinase domain-like(MLKL)(serine 358)and relieves intestinal injury in CLP-induced septic rats with decreased IL-6 and TNF-αlevels.The in vitro experiments further reveal that LPS induces the colocalization of RIP1 and RIP3,resulting in the phosphorylation and translocation of MLKL to the plasma membrane in IEC-6 cells.LPS also facilitates ROS production in IEC-6 cells,but this effect is further reversed by Nec-1,si-RIP1 and si-RIP3.Furthermore,LPS-induced necrosis in IEC-6 cells is counteracted by NAC.Thus,we conclude that RIP1/RIP3-dependent programmed cell necrosis participates in intestinal injury in sepsis and may be associated with RIP1/RIP3-mediated ROS. | Siting Ye Xinxin Qi Yuxiao Liu Liangming Zhuang Zhongmin Gu | 2024 | Acta Biochimica et Biophysica Sinica2024，56，1： | 0 |
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