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	题名	作者	年代	出处	被引量
1	Pyruvate kinase M2 regulates homologous recombination- mediated DNA double-strand break repair显示文摘到 genotoxic 治疗的抵抗是治疗失败和肿瘤复发的一个主要原因。激活 DNA 损坏反应(DDR ) 并且允许癌症房间逃离 genotoxic 治疗的致命的效果的内在的机制仍然保持不清楚。这里,我们揭开通过的意外机制 pyruvate kinase M2 (PKM2 ) ,在癌症房间的高度表示的 PK isoform 和癌症的一个主人管理者新陈代谢的 reprogramming,与 DDR 集成直接支持 DNA 双海滨裂缝(DSB ) 修理。响应电离放射和氧化应力,在导致它的原子累积的 T328 的 ATM phosphorylates PKM2。pT328-PKM2 被要求并且对足够支持通过到在 DNA 的 DSB 和切除术的增加 CtIPs 招募的 T126 上的交往 CtBP 蛋白质(CtIP ) 的 phosphorylation 的调停的 DNA DSB 修理结束的相应再结合(HR ) 。ATM-PKM2-CtIP 轴的混乱敏化癌症房间到许多损坏 DNA 代理人和 PARP1 抑制。而且,增加了原子 pT328-PKM2 水平在 glioblastoma 病人与显著地更坏的幸存被联系。联合,这些数据倡导者是的指向 PKM2 策略的使用不仅破坏癌症新陈代谢而且禁止抵抗的重要机制到 genotoxic 治疗的一个工具。	Steven T. Sizemore Manchao Zhang Ju Hwan Cho Gina M. Sizemore Brian Hurwitz Balveen Kaur Norman L. Lehman Michael C. Ostrowski Pierre A. Robe Weili Miao Yinsheng Wang Arnab Chakravarti Fen Xia	2018	Cell Research2018，28，11：	5
2	Podocalyxin increases the aggressive phenotype of breast and prostate cancer ceils in vitro through its interaction with Ezrin显示文摘	Sizemore S Cicek M Sizemore N	2007	Cancer Res2007，67，13：	1
3	Direct Interactions Between PSD-95 and Stargazin Control Synaptic AMPA Receptor Number 显示文摘	Schnell E Sizemore M Katimzadegan S	2002	Proceedings of the National Academy of Sciences of the United States of America2002，99，13：	1
4	Molecular design of in situ phosphatizing coatings(ISPCs) for aerospace primers 显示文摘	Neuder H Sizemore C Kolody M	2003	Progress in Organic Coatings2003，47，：	1
5	Human behavioral assessment in neurotoxicology: producing appropriate test performance with written and shaping instructions 显示文摘	ANGER WK ROHLMAN DS SIZEMORE O J	1996	Neurotoxicol Teratol1996，18，4：	1
6	Transcriptional regulation of the EGF recepter promoter by HPV16 and retinoic acid in human ectocervical epithelial cell显示文摘	Sizemore N Choo CK Eckert RL	1998	Exp Cell Res1998，244，：	1
7	Growth of broiler chickens in response to feed restriction regimens to reduce ascites显示文摘	Acar N Sizemore F G Leach G R	1995	Poult Sci1995，74，5：	1
8	Attenuated Shigella as a DNA delivery vehicle for DNA-mediated Immunization 显示文摘	Branstrom AA Sadoff JC	1995	Scinece1995，270，：	1
9	Distinct roles of the Ikappa B kinase alpha and beta subunits in liberating nuclear factor kappa B (NF-kappa B) from Ikappa B and in phosphorylating the p65 subunit of NF-kappa B显示文摘	Sizemore N Lerner N Dombrowski N	2002	J Biol Chem2002，277，6：	1
10	The major genetic determinants of HIV-1control affect HLA class I peptide presentation显示文摘	International HIV Controllers Study Pereyra F Jia X McLaren P J Telenti A de Bakker P I Walker B D Ripke S Brumme C J Pulit S L Carrington M Kadie C M Carlson J M Heckerman D Graham R R Plenge R M Deeks S G Gianniny L Crawford G Sullivan J Gonzalez E Davies L Camargo A Moore JM Beattie N Gupta S Crenshaw A Burtt N P Guiducci C Gupta N Gao X Qi Y Yuki Y Piechocka-Trocha A Cutrell E Rosenberg R Moss K L Lemay P O'Leary J Schaefer T Verma P Toth I Block B Baker B Rothchild A Lian J Proudfoot J Alvino D M Vine S Addo M M Allen T M Altfeld M Henn M R Le Gall S Streeck H Haas D W Kuritzkes D R Robbins G K Shafer R W Gulick R M Shikuma C M Haubrich R Riddler S Sax P E Daar E S Ribaudo H J Agan B Agarwal S Ahern R L Allen B L Altidor S Altschuler E L Ambardar S Anastos K Anderson B Anderson V Andrady U Antoniskis D Bangsberg D Barbaro D Barrie W Bartczak J Barton S Basden P Basgoz N Bazner S Bellos N C Benson A M Berger J Bernard N F Bernard A M Birch C Bodner S J Bolan R K Boudreaux E T Bradley M Braun J F Brndjar J E Brown S J Brown K Brown S T Burack J Bush LM Cafaro V Campbell O Campbell J Carlson R H Carmichael J K Casey K K Cavacuiti C Celestin G Chambers S T Chez N Chirch L M Cimoch P J Cohen D Cohn LE Conway B Cooper D A Cornelson B Cox D T Cristofano M V Cuchural G Jr Czartoski J L Dahman J M Daly J S Davis B T Davis K Davod S M DeJesus E Dietz C A Dunham E Dunn M E Ellerin T B Eron J J Fangman J J Farel C E Ferlazzo H Fidler S Fleenor-Ford A Frankel R Freedberg K A French N K Fuchs JD Fuller J D Gaberman J Gallant J E Gandhi R T Garcia E Garmon D Gathe J C Jr Gaultier C R Gebre W Gilman F D Gilson I Goepfert P A Gottlieb M S Goulston C Groger R K Gurley T D Haber S Hardwicke R Hardy W D Harrigan P R Hawkins T N Heath S Hecht F M Henry W K Hladek M Hoffman R P Horton J M Hsu R K Huhn G D Hunt P Hupert M J Illeman M L Jaeger H Jellinger R M John M Johnson J A Johnson K L Johnson H Johnson K Joly J Jordan W C Kauffman C A Khanlou H Killian R K Kim A Y Kim D D Kinder C A Kirchner J T Kogelman L Kojic E M Korthuis P T Kurisu W Kwon D S LaMar M Lampiris H Lanzafame M Lederman M M Lee D M Lee J M Lee M J Lee E T Lemoine J Levy J A Llibre J M Liguori M A Little S J Liu A Y Lopez A J Loutfy M R Loy D Mohammed D Y Man A Mansour M K Marconi V C Markowitz M Marques R Martin J N Martin H L Jr Mayer K H McElrath M J McGhee T A McGovern B H McGowan K McIntyre D Mcleod GX Menezes P Mesa G Metroka CE Meyer-Olson D Miller A O Montgomery K Mounzer K C Nagami E H Nagin I Nahass R G Nelson M O Nielsen C Norene D L O'Connor D H Ojikutu B O Okulicz J Oladehin O O Oldfield E C Olender S A Ostrowski M Owen WF Jr Pae E Parsonnet J Pavlatos A M Perlmutter A M Pierce M N Pincus J M Pisani L Price L J Proia L Prokesch R C Pujet H C Ramgopal M Rathod A Rausch M Ravishankar J Rhame F S Richards C S Richman D D Rodes B Rodriguez M Rose R C 3rd Rosenberg E S Rosenthal D Ross P E Rubin D S Rumbaugh E Saenz L Salvaggio M R Sanchez WC Sanjana V M Santiago S Schmidt W Schuitemaker H Sestak P M Shalit P Shay W Shirvani V N Silebi V I Sizemore J M Jr Skolnik P R Sokol-Anderson M Sosman J M Stabile P Stapleton J T Starrett S Stein F Stellbrink H J Sterman FL Stone V E Stone D R Tambussi G Taplitz R A Tedaldi E M Telenti A Theisen W Torres R Tosiello L Tremblay C Tribble M A Trinh P D Tsao A Ueda P Vaccaro A Valadas E Vanig T J Vecino I Vega V M Veikley W Wade B H Walworth C Wanidworanun C Ward D J Warner D A Weber R D Webster D Weis S Wheeler D A White D J Wilkins E Winston A Wlodaver C G van't Wout A Wright D P Yang O O Yurdin D L Zabukovic B W Zachary K C Zeeman B Zhao M	2010	Science2010，330，6010：	1
11	Milk-alkali syndrome from ingestion of calcium carbonate in a patient with hypoparathyroidism显示文摘	Nabhan FA Sizemore GW Camacho PM	2005	EndocrPract2005，10，4：	1
12	Attenuated Shigella as A DNA Delivery Vehicle for DNA-mediated Immunization显示文摘	Sizemore D R Branstrom A A Sadoff J C	1995	Science1995，270，：	1
13	T-cell-replete HLA- baploidentieal hematopoietic transplantation for hematologic malignancies using post-transplantation cyclophosphamide results in outcomes equivalent to those of contemporaneous HLA-matched related and unrelated donor transplantation显示文摘	Bashey A Zhang X Sizemore CA	2013	J Clin Oncol2013，31，10：	1
14	Total Body Irradiation- Based Myeloablative Haploidentical Stem Cell Transplantation Is a Safe and Effective Alternative to Unrelated Donor Transplantation in Patients Without Matched Sibling Donors显示文摘	Solomon SR Sizemore CA Sanacore M	2015	Biol Blood Marrow Transplant2015，21，7：	1
15	Attenuated shigella as a DNA delivery vehicle for DNA-madiated immunization显示文摘	Branstrom AA sadoff JC	1995	Science1995，270，：	1
16	FDG uptake in inferior vena cava tumor thromhus from renal cell carcinoma on positron emission tomography显示文摘	Sizemore AW Jacobs MP Mantil JC	2007	Clin Nucl Med2007，32，4：	1
17	Surgical management of the adrenal glands in the multiple endocrine neoplasia type Ⅱ syndrome显示文摘	Van Heerden JA Sizemore GW Carney JA	1984	World J Surg1984，8，4：	1
18	Human behavioral assessment in neurotoxicology: producing appropriate test performance with written and shaping instructions 显示文摘	ANGER W K ROHLMAN D S SIZEMORE O J	1996	Neurotoxical Teratol1996，18，4：	1
19	Molecular design of in situ phosphatizing coatings (ISPCs) for aerospace primers显示文摘	Neuder H Sizemore C Kolody M	2003	Progress in Organic Coatings2003，47，：	1
20	Toward a mathematical description of dose-effect functions for self-administered drugs in laboratory animal models显示文摘	Sizemore GM Martin TJ	2000	Psychopharmacology (Berl)2000，153，1：	1

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