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| 1 | 炎症反应与药物治疗在脑动脉瘤治疗中的作用(英文)显示文摘Intracranial aneurysms remain important clinical concern. There is relatively low risk of rupture of symptomless aneurysms incidentally found in MRA or CTA performed due to other indications. Not all of the intracranial aneurysms should or can be treated with neurosurgery intervention or endovascular embolization. Clinical strategy for small, symptomless, unruptured aneurysms is still questionable. Mechanisms underlying aneurysms formation,progression and rupture are poorly understood. Inflammation is one of the factors suspected to participate in these processes. Therefore the aim of this manuscript is to present current state of knowledge about the role of inflammation in the formation and progression of intracranial aneurysms and in their rupture process. Current knowledge about possible pharmacological treatment of intracranial aneurysms will also be presented. Macrophages infiltration seems to participate in the formation of intracranial aneurysms. Inhibition of signals sent by macrophages may prevent the aneurysms formation. Inflammation present in the wall of the aneurysm seems to be also related to the aneurysm's rupture risk. However it does not seem to be the only cause of the degeneration,but it can be a possible target of drug therapy. Some preliminary studies in humans indicate the potential role of aspirin as a factor that decrease the level of inflammation and lower the risk of rupture of intracranial aneurysms. However further research including a greater number of subjects and a prospective randomized design are necessary to assess the role of aspirin in preventing strategy for small,symptomless,unruptured intracranial aneurysms. | Gruszka W Zbroszczyk M Komenda J Gruszczyńska K Baron J | 2018 | 中华神经外科疾病研究杂志2018，17，5： | 3 |
| 2 | Correlations between skin lesions induced by anti-tumor necrosis factor-α and selected cytokines in Crohn's disease patients显示文摘AIM:To investigate the correlation between the appearance of skin lesions and concentration of interleukin(IL)-17A,IL-23 and interferon-γ(IFN-γ)in Crohn’s disease(CD)patients during anti-tumor necrosis factor-α(TNF-α)therapy METHODS:A prospective study included 30 adult patients with CD of Caucasian origin(19 men and 11women;mean age±SD 32.0±8.6 years)during biological therapy with anti-TNF-αantibodies from January2012 to March 2013.Eighteen patients were treated with infliximab,seven with adalimumab and five withcertolizumab.Inclusion criteria were exacerbation of the underlying disease,Crohn’s Disease Activity Index over 300 and the ineffectiveness of previously used non-biological therapies.Patients with a history of psoriasis,atopic dermatitis and other autoimmune skin lesions were excluded from the study.The control group consisted of 12 healthy subjects.A diagnostic survey was carried out,blood tests and careful skin examination were performed,and the serum levels of IL-17,IL-23 and IFN-γwere measured using an enzyme-linked immunosorbent assays technique.Dermatoses that have developed in the course of biological therapy in patients who had no pre-existing skin lesions of similar character were qualified as skin lesions induced by antiTNF-αtherapy.RESULTS:Skin manifestations occurred in 18 of CD patients during the anti-TNF-αtherapy(60%),in the average time of 10.16±3.42 mo following the beginning of the 52-wk treatment cycle.Skin lesions observed in CD patients during biological therapy included psoriasiform lesions(44.4%),and eczema forms lesions(22.2%).In CD patients with drug induced skin lesions significantly higher levels of hemoglobin(13.3±1.5 g/dL vs 10.8±1.9 g/dL,P=0.018)and hematocrit(39.9%±4.5%vs 34.3%±5.4%,P=0.01),as well as a significantly lower level of platelets(268±62×103/μL vs 408±239×103/μL,P=0.046)was observed compared with CD patients without skin manifestations.The concentrations of IL-17A and IL-23in CD patients with skin lesions developed under antiTNF-αtherapy were significantly higher compared to those in patients without lesions(IL-17A:39.01±7.03pg/mL vs 25.71±4.90 pg/mL,P=0.00004;IL-23:408.78±94.13 pg/mL vs 312.15±76.24 pg/mL,P=0.00556).CONCLUSION:Skin lesions in CD patients during bio-logical therapy may result from significantly increased concentrations of IL-17A and IL-23,which are strongly associated with TNF-α/Th1 immune pathways. | Marcin Wodarczyk Aleksandra Sobolewska Bartosz Wójcik Karolina Loga Jakub Fichna Maria Wisniewska-Jarosińska | 2014 | World Journal of Gastroenterology2014，20，22： | 2 |
| 3 | Microstructure and Properties of Nippon Fire- Resistant Steels显示文摘 | Ska W Keny F S | 1999 | Journal of Materials Engineering and Perform- ance1999，10，8： | 1 |
| 4 | Co-composting of poultry manure mixtures amended with biochar - The effect of biochar on temperature and C-CO2 emission显示文摘 | Czeka?a W Malińska K Cáceres R | 2016 | Bioresource Technology2016，200，1： | 1 |
| 5 | Expression of metallothioein in renal tubules of rats exposed to acute and endurance exercise显示文摘 | Podhorska Okoów M Dziegiel P Dolińska Krajewska B | 2006 | Folia Histochemicaet Cytobiological2006，44，3： | 1 |
| 6 | A rare case of nasopharyngeal angiofibroma in an elderly femeale显示文摘 | Szymańska A Korobowicz E Golabek W | 2006 | Eur Arch Otorhinolaryngol2006，263，7： | 1 |
| 7 | Kinetic and adsorptive characterization of biochar in metal ions removal显示文摘 | Kolody(n)ska D Wnetrzak R Leahy J Hayes M Kwapi(n)ski W Hubicki Z | | 0，，： | 1 |
| 8 | Ectomycorrhizal fungal communities of native and non-native Pinus and Quercus species in a common garden of 35-year-old trees显示文摘 | Trocha L K Kalucka I Stasińska M Nowak W Dabert M Leski T Rudawska M Oleksyn J | 2012 | Mycorrhiza2012，22，2： | 1 |
| 9 | Factors affecting the quality of life in hemifacial spasm patients显示文摘 | Rudzińska M Wójcik M Malec M | 2012 | Neurol Neurochir Pol2012，46，2： | 1 |
| 10 | ProGRP and NSE in therapy monitoring in patients with small cell lung caneer显示文摘 | W ojcik E Kulpa JK Sas-Korczy n ska B | 2008 | Anti Cancer Res2008，28，5： | 1 |
| 11 | Trends and dynamics of changes in calcification score over the 1-year observation period in patients on peritoneal dialysis显示文摘 | Tomasz P. Stompór Mieczys?aw Pasowicz W?adys?aw Su?owicz Aldona Dembińska-Kie? Katarzyna Janda Katarzyna Wójcik Wies?awa Tracz Anna Zdzienicka Ma?gorzata Konieczyńska Piotr Klimeczek Eve Janusz-Grzybowska | 2004 | American Journal of Kidney Diseases2004，，3： | 1 |
| 12 | An evaluation of positive organizational behavior in Banking Sector of Pakistan:role of organization based self-esteem and organizational supports显示文摘 | Ismail K Jafri SKA Khurram W | 2011 | Far East Journal of Psychology and Business2011，4，1： | 1 |
| 13 | The frequency of NBN molecular variants in pediatric astrocytic tumors显示文摘 | Piekutowska-Abramczuk D Ciara E Popowska E Grajkowska W Dembowska-Bagińska B Kowalewska E Czajńska A Perek-Polnik M Roszkowski M Syczewska M Krajewska-Walasek M Perek D Chrzanowska KH | 2010 | J Neurooncol2010，96，2： | 1 |
| 14 | Extracellular concentrations of taurine,glutamate,and aspartate in the cerebral cortex of rats at the asymptomatic stage of thioacetamide-induced hepatic failure:modulation by ketamine anesthesia显示文摘 | Albrecht J Hilgier W Zielińska M | 2000 | Neurochem Res2000，25，11： | 1 |
| 15 | Orexins and adipoinsular axis function in the rat显示文摘 | Ma?gorzata M ?witońska Przemys?aw Kaczmarek Ludwik K Malendowicz Krzysztof W Nowak | 2002 | Regulatory Peptides2002，，1： | 1 |
| 16 | Ro le of leptin in hypothalamic pituitary function显示文摘 | YU WH Kimura M W alczew ska A | 1997 | Proc N atlA-cad SciU SA1997，94，： | 1 |
| 17 | ProGRP and NSE in therapy monitoring in patients with small cell lung caneer显示文摘 | W ojcik E Kulpa JK Sas-Korczy n ska B | 2008 | Anti Cancer Res2008，28，5： | 1 |
| 18 | Effect of dietary cadmium and/or lead on histopathological changes in the kidneys and liver of bank voles Myodes glareolus kept in different group densities显示文摘 | Aneta Salińska Tadeusz W?ostowski El?bieta Zambrzycka | 2012 | Ecotoxicology2012，，8： | 1 |
| 19 | A Headspace–SPME–MS Method for Monitoring Rapeseed Oil Autoxidation显示文摘 | H. H. Jeleń S. Mildner-Szkudlarz I. Jasińska E. W?sowicz | 2007 | Journal of the American Oil Chemists’ Society2007，，6： | 1 |
| 20 | Red blood cell and plasma glutathione peroxidase activities and selenium concentration in patients with chronic kidney disease:a review显示文摘 | Zachara BA Gromadzińska J Wasowicz W | 2006 | Acta Biochim Pol2006，53，4： | 1 |
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