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| 1 | Role of surgery in colorectal liver metastases:Too early or too late?显示文摘As colorectal cancer and colorectal liver metastases become a serious public health problem,new treatment modalities are needed in order to achieve better results. In the last decade there has been very important progress in oncology,with new and more effective chemotherapeutic agents administered alone or in combination improving the resectability rate in up to 40%of patients with colorectal liver metastases.Advances in interventional radiology,in particular,with the use of portal vein embolization and radiofrequency thermal ablation are new strategies allowing major liver resections and treatment of small liver metastases or early recurrences.Surgery,however,remains the gold standard strategy with intention to treat.In this review article we will describe the advanced role of surgery in the multidisciplinary approach to colorectal liver metastases,and the clinical problems the liver surgeon has to deal with,such as theresectability of the metastases,the presence of bilobar liver lesions and extrahepatic disease,the impact of chemotherapy in already resectable liver metastases,the problem of vanishing metastases after chemotherapy and the dilemma of staged or combined liver and colon operations and which organ first in the clinical scenario of synchronous colorectal liver metastases. | Dimitrios Dimitroulis Nikolaos Nikiteas Theodore Troupis Dimitrios Patsouras Panayiotis Skandalakis Gregory Kouraklis | 2010 | World Journal of Gastroenterology2010，16，28： | 5 |
| 2 | Bilateralbreast cancer 显示文摘 | Gogas J Markopoulos C Skandalakis P | 1993 | Am Surg1993，59，11： | 1 |
| 3 | Strangulated obturator hernia显示文摘 | Gray SW Skandalakis JE Soria RE | 1974 | Surgery1974，75，1： | 1 |
| 4 | Surgical anatomy of the retroperitoneal spaces, Part V: Surgical apphcations and complications 显示文摘 | Mirilas P Skandalakis JE | 2010 | Am Surg2010，76，4： | 1 |
| 5 | Constipation of anorectal outlet obstruction:Pathophysiology, evaluation and management 显示文摘 | Andromanakos N Skandalakis P Troupis T | 2006 | Gastroenterol Hepatol2006，21，4： | 1 |
| 6 | Benign anatomical mistakes: inferior pulmonary ligament显示文摘 | Mirilas P Siatitsas Y Skandalakis JE | 2002 | Am Surg2002，68，10： | 1 |
| 7 | Hepatic surgery and hepatic surgical anatomy:historical partners in progress显示文摘 | McClusky DA 3rd Skandalakis LJ | 1997 | World J Surg1997，21，： | 1 |
| 8 | Zuckerkandl's tubercle:hannibal ad portas显示文摘 | Mirilas P Skandalakis JE | | 0，，05： | 1 |
| 9 | Embrologic and anatomic basis of inguinal herniorrhaphy显示文摘 | John E skandalakis Gene L | 1993 | Sury clin North Am1993，73，4： | 1 |
| 10 | Surgical anatomy of the liver and associated extrahepatic structures显示文摘 | Skandalakis JE | 1987 | Contemporary Surg1987，，30： | 1 |
| 11 | Constipation of anoreetal outlet obstruction: pathophysiology, evaluation and management显示文摘 | Andromanakos N Skandalakis P Troupis T et ol | 2006 | J Gastroenterol Hepatol2006，21，4： | 1 |
| 12 | Hepatic surgery and hepatic surgical anatomy: historical partners in progress 显示文摘 | McClusky DA Skandalakis LJ Colbom GL | 1997 | World J Surg1997，21，3： | 1 |
| 13 | Hepatic surgery and hepatic surgical anatomy: historical partners in progress显示文摘 | McClusky DA 3rd Skandalakis LJ Colborn GL | 1997 | World J Surg1997，21，3： | 1 |
| 14 | Hepatic Surgery and Hepatic Surgical Anatomy:Historical Partners in Progress显示文摘 | McClusky DA Skandalakis LJ Colborn GL | 1997 | {H}WORLD Journal OF SURGERY1997，，03： | 1 |
| 15 | Constipation of anorectal outlet obstruction:Pathophysiology,evaluation and management显示文摘 | Andromanakos N Skandalakis P Troupis T | | 0，，04： | 1 |
| 16 | The surgrical anatomy of the spleen显示文摘 | Skandalakis PN Colborn GL Skandalakis LJ | 1993 | Surg Clin North Am1993，73，4： | 1 |
| 17 | Congenital fusion of the cervical vertebrae 显示文摘 | Gray SW Romaine CB Skandalakis JE | 1964 | Surg Gynecol Obstet1964，118，： | 1 |
| 18 | Obturator hernia revisited:surgical anatomy,embryology,diagnosis,and technique of repair显示文摘 | Stamatiou D Skandalakis LJ Zoras O | | 0，，： | 1 |
| 19 | Isolated Splenic Metastasis From Rectal Carcinoma显示文摘 | PETER J. CAPIZZI KEITH B. ALLEN J R AMERSON JOHN E. SKANDALAKIS | 1992 | Southern Medical Journal1992，，10： | 1 |
| 20 | Strangulated obturator hernia显示文摘 | Gray SW Skandalakis JE Sofia RE | 1974 | Surgery1974，75，1： | 1 |
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