|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Antibiotic-loaded phosphatidylcholine inhibits staphylococcal bone infection显示文摘AIM: To test antibiotic-loaded coating for efficacy in reducing bacterial biofilm and development of osteomyelitis in an orthopaedic model of implant infection. METHODS: Phosphatidylcholine coatings loaded with 25% vancomycin were applied to washed and sterilized titanium wires 20 mm in length. A 10 mm segment was removed from rabbit radius(total = 9; 5 coated, 4 uncoated), and the segment was injected with 1 × 106 colony forming units(CFUs) of Staphylococcus aureus(UAMS-1 strain). Titanium wires were inserted throughthe intramedullary canal of the removed segment and into the proximal radial segment and the segment was placed back into the defect. After 7 d, limbs were removed, X-rayed, swabbed for tissue contamination. Wires were removed and processed to determine attached CFUs. Tissue was swabbed and streaked on agar plates to determine bacteriological score.RESULTS: Antibiotic-loaded coatings resulted in significantly reduced biofilm formation(4.7 fold reduction in CFUs; P < 0.001) on titanium wires and reduced bacteriological score in surrounding tissue(4.0 ± 0 for uncoated, 1.25 ± 0.5 for coated; P = 0.01). Swelling and pus formation was evident in uncoated controls at the 7 d time point both visually and radiographically, but not in antibiotic-loaded coatings.CONCLUSION: Active antibiotic was released from coated implants and significantly reduced signs of osteomyelitic symptoms. Implant coatings were well tolerated in bone. Further studies with additional control groups and longer time periods are warranted. Antibiotic-loaded phosphatidylcholine coatings applied at the point of care could prevent implant-associated infection in orthopaedic defects. | Jessica Amber Jennings Karen E Beenken Robert A Skinner Daniel G Meeker Mark S Smeltzer Warren O Haggard Karen S Troxel | 2016 | World Journal of Orthopedics2016，7，8： | 2 |
| 2 | A new model for the secondary structure of the 5' non-coding RNA of poliovirus is supported by biochemical and genetic data that also show that RNA secondary structure is important in neurovirulence显示文摘 | Skinner M A Racaniello V R Dunn G | 1989 | J Mol Biol1989，207，2： | 1 |
| 3 | Expression and action of kit ligand/stem cell factor in normal human and bovine ovarian surface epithelium and ovarian cancer 显示文摘 | Parrott JA Kim G Skinner MK | 2000 | Biology of Reproduction2000，62，6： | 1 |
| 4 | An information privacy taxonomy for collaborative environments 显示文摘 | Skinner G Han S Chang E | 2006 | Information management & com- puter security2006，14，4： | 1 |
| 5 | Which patients are suitable for continent diversion or bladder substitution following cystectomy or other definitive local treatment?显示文摘 | SKINNER D G STUDER U E OKADA K | 1995 | Int J Urol1995，2，2： | 1 |
| 6 | Increased oxidative modifications of amniotic fluid albumin in pregnancies associated with gestational diabetes mellitus显示文摘 | Boisvert M R Koski K G Skinner C D | 2010 | Anal Chem2010，82，3： | 1 |
| 7 | Analytical far-field divergence angle of a truncated Gaussian beam显示文摘 | Emmanuel M Drvge Neal G Skinner Dale M Byrne | 2000 | Appl Opt2000，39，27： | 1 |
| 8 | Nitrogen uptake and partitioning under alternate-and every-furrow irrigation显示文摘 | SKINNER R H HANSON J D BENJAMIN J G | 1999 | Plant and Soil1999，210，1： | 1 |
| 9 | A prospective study of folate intake and the risk of pancreatic cancer in men and women显示文摘 | Skinner H G Michaud D S Giovannueci E L Rimm E B Stampfer M J Willett W C | 2004 | Am J Epidemiol2004，160，： | 1 |
| 10 | Analytical farfield divergence angle of a truncated Gaussian beam显示文摘 | DRE'GE E M SKINNER N G BYME D M | 2000 | Appl Opt2000，39，27： | 1 |
| 11 | Options in replacement cystoplasty following radical cystectomy: high hope or successful reality 显示文摘 | Martins F E Bennett C J Skinner D G | 1995 | J Urol1995，153，5： | 1 |
| 12 | Interorganizational depend- ence and control as predictors of opportunism in dealer-supplier relations 显示文摘 | Provan K G Skinner S J | 1989 | The Academy of Man- agement Journal1989，32，1： | 1 |
| 13 | Post-operative feeding strategies for infants with cleft lip显示文摘 | Skinner J Arvedson JC Jones G | 1997 | lnt J Pediatr Otorhinolaryn- gnl1997，1042，2： | 1 |
| 14 | Options in replacement cystoplasty following radical cystectomy:high hopes or successful reality显示文摘 | Martins F E Bennett C J Skinner D G | | 0，，05： | 1 |
| 15 | Clinical experience with the Kock continent ileal reservoir for urinary diversion显示文摘 | SKINNER D G BOYD S D LIESKOVSKY G | 1984 | J Urol1984，132，6： | 1 |
| 16 | Completion of the sequence of the genome of the coronavirus avian infectious bronchitis virus 显示文摘 | BOURSNELL M E G BROWN T D K SKINNER M | 1987 | J Gen Virol1987，68，： | 1 |
| 17 | Earnings surprises, growth expectations, and stock returns or don't let an earnings torpedo sink your portfolio显示文摘 | Skinner D J Sloan R G | 2002 | Review of Accounting Studies2002，7，23： | 1 |
| 18 | The repeat sequence of a hermitcrab satellite deoxyribo nucleica cidis(-T-A-G-G-)n,(-A-T-C-C-)n显示文摘 | Skinner D M Beattie W G Blattner F R | 1974 | Biochemistry1974，13，： | 1 |
| 19 | Phylogenetic analysis of Sorghum and related taxa using internal transcribed spacers of nuclear ribosomal DNA 显示文摘 | SUN Y SKINNER D Z LIANG G H | 1994 | Theor Appl Genet1994，89，： | 1 |
| 20 | Smart Surface chemistry and rheological behaviour of titania pigment suspensions显示文摘 | Gayle E Morris William A Skinner Peter G Self Roger St C | 1999 | Colloids and Surfaces1999，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员