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| 1 | Etiology and functional status of liver cirrhosis by ^(31)P MR spectroscopy显示文摘AIM: To assess the functional status and etiology of liver cirrhosis by quantitative 31p magnetic resonance spectroscopy (MRS).METHODS: A total of 80 patients with liver cirrhosis of different etiology and functional status described by Child-Pugh score were examined and compared to 11 healthy volunteers. MR examination was performed on a 1.5 T imager using a 1H/31P surface coil by the 2D chemical shift imaging technique.Absolute concentrations of phosphomonoesters (PME),phosphodiesters (PDE), inorganic phosphate (Pi) and adenosine triphosphate (ATP) were measured.RESULTS: MRS changes reflected the degree of liver dysfunction in all the patients as well as in individual etiological groups. The most important change was a decrease of PDE. It was possible to distinguish alcoholic,viral and cholestatic etiologies based on MR spectra.Alcoholic and viral etiology differed in PDE (alcoholic,viral, controls: 6.5±2.3, 6.5±3.1, 10.8±2.7 mmol/L,P<0.001) and ATP (alcoholic, viral, controls: 2.9±0.8, 2.8±0.9, 3.7±1.0 mmol/L, P<0.01) from the control group.Unlike viral etiology, patients with alcoholic etiology also differed in Pi (alcoholic, controls: 1.2±0.4, 1.6±0.6mmol/L, P<0.05) from controls. No significant changes were found in patients with cholestatic disease and controls; nevertheless, this group differed from both alcoholic and viral groups (cholestatic, alcoholic, viral: 9.4±2.7, 6.5±2.3, 6.5±3.1 mmol/L, P<0.005) in PDE.CONCLUSION: 31p MRS can significantly help in noninvasive separation of different etiological groups leading to liver cirrhosis. In addition, MRS changes reflect functional liver injury. | Monika Dezortova Pavel Taimr Antonin Skoch Julius Spicak Milan Hajek | 2005 | World Journal of Gastroenterology2005，11，44： | 17 |
| 2 | Surgical anatomy of the minimally invasive lateral lumbar approach显示文摘 | Bina RW Zoccali C Skoch J | 2015 | J Clin Neurosci2015，22，3： | 1 |
| 3 | In vivooptical imaging of amyloid aggregates in brain: de-sign of fluorescent markers 显示文摘 | Nesterov E E Skoch J Hyman B T | 2005 | Angew Chem IntEd Engl2005，44，34： | 1 |
| 4 | Four-dimensional muhiphoton imaging of brain entry, amyloidbinding, and clearance of an amyloid-beta ligand in transgenic mice 显示文摘 | Bacskai BJ Hickey GA Skoch J | 2003 | Proc Natl Acad SciUSA2003，100，12： | 1 |
| 5 | Electroporation loading of calcium-sensitive dyes into the CNS显示文摘 | Agens Bonnot George Z Mentis Jesse Skoch | | 0，，03： | 1 |
| 6 | Effects of steam pel- leting conditions and extrusion cooking on a swine diet contain- ing wheat middlings显示文摘 | Skoch E R Binder S F Deyoe C W | 1983 | Journal of Animal Science1983，57，4： | 1 |
| 7 | An investigation of surge in a high-speed centrifugal compressor using digital PIV 显示文摘 | Wemet P Bright M Skoch J | 2001 | Journal of Turbomachinery2001，123，2： | 1 |
| 8 | Experimental Investigation of Centrifugal Compressor Stabilization Techniques显示文摘 | Skoch G J | 2003 | Journal of Turbomachinery2003，125，： | 1 |
| 9 | Experimental Investigation of Diffuser Hub Injection to Improve Centrifugal Compressor Stability显示文摘 | Skoch G J | 2005 | Journal of Turbomachinery2005，127，： | 1 |
| 10 | Effects of steam pelleting conditions and extrusion cooking on a swine diet containing wheat middlings显示文摘 | SKOCH E R BINDER S F DEYOE C W | 1983 | J Anita Sci1983，57，： | 1 |
| 11 | Diffusion tensor imaging and MR morphometry of the central auditory pathway and auditory cortex in aging显示文摘 | PROFANT O SKOCH A BALOQOVA Z | 2014 | Neuroscience2014，260，： | 1 |
| 12 | Amyloid precursor protein associates with a nicastrin-dependent docking site on the presenilin 1-γ-secretase complex in cells demonstrated by fluoresence lifetime imaging显示文摘 | Berezovska O Ramdya P Skoch J | 2003 | J Neurosci2003，23，11： | 1 |
| 13 | Fluorescent-lifetime-based tomography for turbid media显示文摘 | KUMAR A T N SKOCH J BACSKAI B J | 2005 | Opt Lett2005，30，24： | 1 |
| 14 | Physical and functional connection between auxilin and dynamin during endocytosis显示文摘 | Sever S Skoch J Newmyer S | 2006 | EMBO2006，25，18： | 1 |
| 15 | Magnetic resonance spectroscopy of the thalamus in patients with mesial temporal lobe epilepsy and hippocampal sclerosis 显示文摘 | Fojtikova D Brazdil M Skoch A | 2007 | Epileptic Disord2007，，1： | 1 |
| 16 | Fluorescent-lifetimebased tomography for turbid media显示文摘 | Kumar A T N Skoch J Bacskai J | 2005 | Optics Letters2005，30，24： | 1 |
| 17 | Fluorescence resonance energy transfer determinations using multiphoton fluorescence lifetime imaging microscopy to characterize amyloid-beta plaques 显示文摘 | Bacskai B J Skoch J Hickey GA | 2003 | J Biomed Opt2003，8，3： | 1 |
| 18 | Freehand thoracic pedicle screw technique using a uniform entry point and sagittal trajectory for all levels: preliminary clinical experience 显示文摘 | Fennell VS Palejwala S Skoch J | 2014 | J Neurosurg Spine2014，21，5： | 1 |
| 19 | Experimental investigation of centrifugal compressor stabilization techniques显示文摘 | Skoch G J | 2003 | ASME Journal of Turbomachinery2003，125，： | 1 |
| 20 | In vivo optical imaging of amyloid aggregates in brain: design of fluorescent markers显示文摘 | Nesterov E E Skoch J Hyman B T | 2005 | Angew Chem Int Ed Engl2005，44，34： | 1 |
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