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| 1 | Multiplex RT-PCR-based detections of CEA, CK20 and EGFR in colorectal cancer patients显示文摘AIM: To develop a multiplex reverse transcription polymerase chain reaction (RT-PCR) method detecting cir-culating tumor cells in the peripheral blood of colorectal cancer (CRC) patients. METHODS: Peripheral blood samples were collected from 88 CRC patients and 40 healthy individuals from the blood donors' clinic and subsequently analyzed by multiplex RT-RCR for the expression of carcinoembryonic antigen (CEA), cytokeratin 20 (CK20) and epidermal growth factor receptor (EGFR) mRNA. The analysis involved determining the detection rates of CEA, CK20 and EGFR transcripts vs disease stage and overall survival. Median follow-up period was 19 mo (range 8-28 mo). RESULTS: Rates of CEA, CK20 and EGFR detection in CRC patients were 95.5%, 78.4% and 19.3%, respectively. CEA transcripts were detected in 3 healthy volunteer samples (7.5%), whereas all control samples were tested negative for CK20 and EGFR transcripts. The increasing number of positive detections for CEA, CK20 and EGFR transcripts in each blood sample was positively correlated with Astler-Coller disease stage (P< 0.001) and preoperative serum levels of CEA (P=0.029) in CRC patients. Data analysis using Kaplan-Meier estimator documented signif icant differences in the overall survival of the different CRC patient groups as formed according to the increasing number of positivity for CEA, CK20 and EGFR transcripts. CONCLUSION: These data suggest that multiplex RTPCR assay can provide useful information concerning disease stage and overall survival of CRC patients. | Aikaterini Tsouma Chrysanthi Aggeli Panagiotis Lembessis George N Zografos Dimitris P Korkolis Dimitrios Pectasides Maria Skondra Nikolaos Pissimissis Anastasia Tzonou Michael Koutsilieris | 2010 | World Journal of Gastroenterology2010，16，47： | 19 |
| 2 | Near infrared autofluo- rescence imaging of retinal diseases显示文摘 | D Skondra TD Papakostas R Hunter | 2012 | Seminars in Ophthalmology2012，27，56： | 1 |
| 3 | The role of tenofovir in preventing and treating hepatitis B virus (HBV) reactivation in immunosuppressed patients. A real life experience from a tertiary center显示文摘 | J.S. Koskinas M. Deutsch S. Adamidi M. Skondra M. Tampaki A. Alexopoulou S. Manolakopoulos D. Pectasides | 2014 | European Journal of Internal Medicine2014，，8： | 1 |
| 4 | Intraobserver repeata bility of macular measurements by confodal scanning laser tomography显示文摘 | Pallikaris A Skondra D Tsilimbaris M | 2005 | Am J Ophthalmol2005，139，： | 1 |
| 5 | Characterization of azurocidin as a permeability factor in the retina:Involvement in VEGF-induced and early diabetic blood-retinal barrier breakdown 显示文摘 | Skondra D Noda K Almulki L | 2008 | Invest Ophthalmol Vis Sci2008，49，： | 1 |
| 6 | Near infrared autofluorescence imaging of retinal diseases显示文摘 | Skondra D Papakostas TD Hunter R | 2012 | Semin Ophthalmol2012，27，56： | 1 |
| 7 | Characterization of azurocidin as a permeability factor in the retina:involvement in vegf-induced and early diabetic blood-retinal barrier breakdown显示文摘 | SKONDRA D NODA K ALMULKI L | 2008 | Investigative Ophthalmology and Visual Science2008，49，2： | 1 |
| 8 | lntraobserver repeatability of macula measurements by confocal scanning laser tomography显示文摘 | Pallikaris A Skondra D Tsilimbaris M | 2005 | Am J Ophthalmol2005，139，4： | 1 |
| 9 | Characterization of azurocidin as a permeability factor in the retina:involvement in VEGF-induced and early diabetic blood-retinal barrier breakdown显示文摘 | Skondra D Noda K Almulki L | 2008 | Invest Ophthalmol Vis Sci2008，49，： | 1 |
| 10 | Near infraredautofluorescence imaging of retinal diseases 显示文摘 | Skondra D Papakostas TD Hunter R Vawas DG | 2012 | Semin Oph-thalmolt2012，21，56： | 1 |
| 11 | Wyburn-Mason syndrome associated with cutaneous reactive angiomatosis and central retinal vein occlusion显示文摘 | Callahan AB Skondra D Krzystolik M | 2015 | Ophthalmic Surg Lasers Imaging Retina2015，46，7： | 1 |
| 12 | Presurgical planning in implant restorations:correct interpretation of cone-beam computed tomography for improved imaging显示文摘 | Kourtis S Skondra E Roussou I | 2012 | J Esthet Restor Dent2012，24，5： | 1 |
| 13 | Effects of soil water potential on the nitrate content and the yield of lecture 显示文摘 | Aggelides S Assimakopoulos I Kerkides P Skondras A | 1999 | Commun Soil Plant Anal1999，30，12： | 1 |
| 14 | Application and assessment of the Environmental Vulnerability Index in Greece显示文摘 | NIKOLAOS A SKONDRAS CHRISTOS A KARAVITIS | 2011 | Ecological Indicators2011，11，6： | 1 |
| 15 | Treves' field congenital hernias in children : An un - suspected rare cause of acute small bowel obstruction 显示文摘 | Vaos G Skondras C | 2007 | Pe- diatr Surg Int2007，23，4： | 1 |
| 16 | Implication of gut microbiome in age-related macular degeneration显示文摘Age-related macular degeneration(AMD) is the most common cause of blindness in the United States in adults over 55 years of age and is one of the leading global causes of blindness: at least 196 million of the worldwide population have AMD, and prevalence is projected to rise to 288 million by 2040(Lin et al., 2021). As cases and disease burden increase, improvements in the characterization of AMD pathobiology and exploration of potential therapeutic solutions are necessary first steps in addressing this global health concern. | Wendy Luo Dimitra Skondra | 2023 | Neural Regeneration Research2023，18，12： | 0 |
| 17 | 唐氏综合征患儿由于反复的绞窄性Morgagni疝所导致的结肠坏死显示文摘Postoperative bowel obstruction complicating a recurrent Morgagni’s hernia (MH) is an uncommon condition and hence the presentation. Nonspecific symptoms andmisleading radiologic image may result in misdiagnosis and severe complications. We report the case of a child with a transverse colon necrosis because of strangulation in a misdiagnosed recurrent MH. The child presented with bowel obstruction and repeated chest infections. Colonic necrosis could be avoided by timely diagnosis and repair of MH. This severe and rare occurrence complicating a recurrent MH should be kept in mind in children with respiratory tract infections and vomiting. | Vaos G. Skondras C. 李丹 | 2006 | 世界核心医学期刊文摘(儿科学分册)2006，0，9： | 0 |
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