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| 1 | 高级别胶质瘤放、化疗耐药性可能与microRNAs相关(英文)显示文摘High-grade gliomas(HGGs) are malignant primary brain tumors of glial cell origin.Despite optimal course of treatment,including maximal surgical resection followed by adjuvant chemo-and/or radiotherapy,the prognosis still remains poor.The main reason is the commonly occurring chemo-and radioresistance of these tumors.In recent years,several signaling pathways,especially PI3K/AKT and ATM/CHK2/p53,have been linked to the resistance of gliomas.Moreover,additional studies have shown that these pathways are significantly regulated by microRNAs(miRNAs),short endogenous RNA molecules that modulate gene expression and control many biological processes including apoptosis,proliferation,cell cycle,invasivity,and angiogenesis.MiRNAs are not only highly deregulated in gliomas,their expression signatures have also been shown to predict prognosis and therapy response.Therefore,they present promising biomarkers and therapeutic targets that might overcome the resistance to treatment and improve prognosis of glioma patients.In this review,we summarize the current knowledge of the functional role of miRNAs in gliomas resistance to chemo-and radiotherapy. | Besse A Sana J Fadrus P Slaby O | 2013 | 中华神经外科疾病研究杂志2013，12，2： | 3 |
| 2 | Mantled alkali-feldspar megacrysts from the marginal part of the Karkonosze granitoid massif (SW Poland)显示文摘 | Slaby E Galbarczyk-Gasiorowska L Baszkiewicz A | 2002 | Acta Geologica Polonica2002，52，4： | 1 |
| 3 | Identification of MicroRNAs associated with early relapse after nephrectomy in renal cell carcinoma patients显示文摘 | Slaby O Redova M Poprach A | | 0，，07： | 1 |
| 4 | Xanthomas: clinical and pathophysiologieal re- lations显示文摘 | Zak A Zeman M Slaby A | 2014 | Biomed Pap Med Fac Univ Palacky Olomouc Repub2014，158，2： | 1 |
| 5 | Megacrysts and salic xenoliths in Scottish alkali basalts:Derivatives of deep crustal in- trusions and small-melt fractions from the upper mantle显示文摘 | Upton B G J Finch A A Slaby E | 2009 | Mineralogical Magazine2009，73，6： | 1 |
| 6 | Synthesis, characterization, and in vitro antitumor activity of osteotropic diam (in) ineplatinum( Ⅱ ) complexes bearing a N,N-bis( phosphono- methyl)glycine ligand显示文摘 | GALANSKI M SLABY S JAKUPEC M A | 2003 | J Med Chem2003，46，23： | 1 |
| 7 | Synthesis and in vitro antitumor potency of (cyclohexane-1,2-diamine) platinum ( Ⅱ ) complexes with aminotris (methylenephosphonic acid ) as bone-seeldng ligand 显示文摘 | GALANSKI M SLABY S JAKUPEC M A | 2005 | Bioinorg Chem Appl2005，3，34： | 1 |
| 8 | Identification of MicroRNAs associated with early relapse after nephrectomy in renal cell carci- noma patients 显示文摘 | Slaby O Redova M Poprach A | 2012 | Genes Chromosomes Cancer2012，51，7： | 1 |
| 9 | Expression of miRNA-106b in conventional renal cell carcinoma is a potential marker for prediction of early metastasis after nephrectomy显示文摘 | Slaby O Jancovicova J Lakomy R Svoboda M Poprach A Fabian P | | 0，，： | 1 |
| 10 | Synthesis,characterization, and in vitro antitumor activity of osteotropic diam(m)ineplatinum(Ⅱ) complexes bearing a N,N-bis(phosphonomethyl) glycine ligand显示文摘 | Galanski M Slaby S Jakupec M A | 2003 | J Med Chem2003，46，23： | 1 |
| 11 | Ameloblastin fusion protein enhances pulpal healing and dentin formation in porcine teeth显示文摘 | Nakamura Y Slaby I Spahr A | | 0，，05： | 1 |
| 12 | Identification of MicroRNAs associated with early relapse after nephrectomy in renal cell carcinoma patients显示文摘 | SLABY O REDOVA M POPRACH A | 2012 | Genes Chromosomes Cancer2012，51，7： | 1 |
| 13 | Xanthomas:clinical and pathophysiological relations显示文摘 | Zak A Zeman M Slaby A | 2014 | Biomed Pap Med Fae Univ Palaeky Olomouc Czech Repub2014，158，2： | 1 |
| 14 | Identification of MicroR-NAs associated with early relapse after nephrectomy in renal cellcarcinoma patients 显示文摘 | Slaby 0 Redova M Poprach A | 2012 | Genes Chromosomes Cancer2012，51，7： | 1 |
| 15 | Intracranial haemorrhage as initial presentation of severe haemophilia B: Case report and review of mayo clinic comprehensive hemophil- ia center experience 显示文摘 | Rodriguez V Schmidt K A Slaby J A | 2005 | Haemophilia2005，11，1： | 1 |
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