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| 1 | Analysis of the phosphatidylinosit ol 3'-kinase signaling pathway in glioblastoma patients in vivo显示文摘Deregulated signaling through the p hosphatidylinositol 3-kinase(PI3K)pathway is common in many types of can cer,including glioblastoma.Dissecting the molecular events associated with activation of this pathway in glioblastoma p atients in vivo presents an important challenge that has implic ations for the development and clini cal testing of PI3K pathway inhibito rs.Using an immunohistochemical analysis appl ied to a tissue microarray,we performed hierarchical clustering and mul tidimensional scaling,as well as univariate and multivariate analyses,to dissect the PI3K pathway in v ivo.We demonstrate that loss of the t umor suppressor protein PTEN,which antagonizes PI3K pathwa y activation,is highly correlated w ith activation of the main PI3K effec tor Akt in vivo.We also show that Akt activation is signific antly correlated with phosphorylation of mammalian target of rapamycin(mTOR),the family of forkhead transcription factors(FOXO1,FOXO3a,and FOXO4),and S6,which are thought to promote its effects.Expression of the mutan t epidermal growth factor receptor vIII is also tightly correlated with phosphorylation of these effectors,d emonstrating an additional route to PI3K pathway activation in glioblastomas in vivo.These results provide the first dissection of the PI3K path way in glioblastoma in vivo and suggest an approach to stratifying patients for targeted kinase inhi bitor | Choe G Horvath S Cloughesy TF Crosby K Seligson D Palotie A Inge L Smith BL Sawyers CL Mischel PS | 2003 | 癌症2003，22，7： | 41 |
| 2 | Laboratory diagnosis of CHS infection with HSV by PCR performed with CSF specimens 显示文摘 | Mitchell PS Espy M J Smith TF | 1997 | J Clin Microbiol1997，35，11： | 2 |
| 3 | Uterine compression sutures as an alternative to hysterectomy for severe postpartum hemorrhage 显示文摘 | Smith KL Baskett TF | 2003 | J Obstet Gynaecol Can2003，25，3： | 1 |
| 4 | Arbovirus infections in Sarawak:the role of the domestic pig显示文摘 | Simpson DI Smith CE Marshall TF | 1976 | Trans R Soc Trop Med Hyg1976，70，1： | 1 |
| 5 | The WD repeat : a com- mon architecture for diverse functions 显示文摘 | Smith TF Gaitatzes C Saxena K | 1999 | Trends Biochem Sci1999，24，5： | 1 |
| 6 | From theory to practice: a determinants approach to workplace health promotion in small businesses 显示文摘 | Eakin JM Cava M Smith TF | 2001 | Health Promotion Practice2001，2，： | 1 |
| 7 | The mouse Gene Expression Database(GXD):2007 update显示文摘 | Smith CM Finger JH Hayamizu TF | 2006 | Nucleic Acids Res2006，，： | 1 |
| 8 | Avian influenza: a new pandemic threat? 显示文摘 | Trampuz A Prabhu RM Smith TF | 2004 | Mayo Clin Proc2004，79，4： | 1 |
| 9 | Thirty-plus functional families from a single motif显示文摘 | Yu LH Gaitatzes C Neer E Smith TF | 2000 | Protein Sci2000，9，12： | 1 |
| 10 | Evaluation of PCR primers for early diagnosis of cytomegalovirus infection following liver transplantation 显示文摘 | Mendez JC Espy MJ Smith TF | 1998 | J Clin Microbiol1998，36，2： | 1 |
| 11 | The WD-repeat:a common architecture for diverse functions显示文摘 | Smith TF Gaitatzes CG Saxena K | 1999 | TIBS1999，24，： | 1 |
| 12 | Quantitative real- time polymerase chain reaction for evaluating DNAemia due to eytomegalovirus, Epstein-Barr virus, and BK virus in solid-organ transplant recipients显示文摘 | Smith TF Espy MJ Mandrekar J | 2007 | Clin Infect Dis2007，45，8： | 1 |
| 13 | Role of the laboratory in diagnosis and management of cytomegalovirus infection in hematopoietic stem cell and solid-organ transplant recipients显示文摘 | Razonable RR Paya CV Smith TF | 2002 | J Clin Microbiol2002，40，3： | 1 |
| 14 | Identification of common molecular subsequences显示文摘 | Smith TF Waterman MS | 1981 | J Mol Biol1981，147，1： | 1 |
| 15 | The WD repeat:a common architecture for diverse functions显示文摘 | Smith TF Gaitatzes C Saxena K | 1999 | Trends Biochem Sci1999，24，5： | 1 |
| 16 | The WD-repeat: a common architecture for diverse functions显示文摘 | Smith TF Gaitatzes CG Saxena K | 1999 | TIBS1999，24，： | 1 |
| 17 | Mycoplasma pneumoniae pneumonia显示文摘 | Mansel JK Rosenow EC Smith TF | 1989 | Chest1989，95，3： | 1 |
| 18 | Diversity of WD-repeat proteins显示文摘 | Smith TF | 2008 | Subcell Biochem2008，48，： | 1 |
| 19 | Role of the laboratory in diagnosis and management of cytomegalovirus infection in hematopoietic stem cell and solid-organ transplant recipients显示文摘 | Razonable RR Paya CV Smith TF | 2002 | J Clin Microbiol2002，40，： | 1 |
| 20 | Mycoplasma pneumoniae pneumonia显示文摘 | Mansel JK Rosenow EC 3rd Smith TF | 1989 | Chest1989，95，3： | 1 |
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