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| 1 | Four-year follow-up of endoscopic gastroplication for the treatment of gastroesophageal reflux disease显示文摘AIM:To evaluate the long-term effect of Endocinch treatment for gastroesophageal reflux disease(GERD).METHODS:After unblinding and crossover,50 patients(32 males,18 females; mean age 46 years) with pH-proven chronic GERD were recruited from an initial randomized,placebo-controlled,single-center study,and included in the present prospective open-label follow-up study.Initially,three gastroplications using the Endocinch device were placed under deep sedation in a standardized manner.Optional retreatment was offered in the first year with 1 or 2 extra gastroplications.At baseline,3 mo after(re) treatment and yearly proton pump inhibitor(PPI) use,GERD symptoms,quality of life(QoL) scores,adverse events and treatment failures(defined as:patients using > 50% of their baseline PPI dose or receiving alternative antireflux therapy) were assessed.Intention-to-treat analysis was performed.RESULTS:Median follow-up was 48 mo [interquartile range(IQR):38-52].Three patients were lost to follow-up.In 44% of patients retreatment was done after a median of 4 mo(IQR:3-8).No serious adverse events occurred.At the end of follow-up,symptom scores and4 out of 6 QoL subscales were improved(all P < 0.01compared to baseline).However,80% of patients required PPIs for their GERD symptoms.Ultimately,64% of patients were classified as treatment failures.In 60% a post-procedural endoscopy was carried out,of which in 16% reflux esophagitis was diagnosed.CONCLUSION:In the 4-year follow-up period,the subset of GERD patients that benefit from endoscopic gastroplication kept declining gradually,nearly half opted for retreatment and 80% required PPIs eventually. | Matthijs P Schwartz J Rieneke C Schreinemakers André J P M Smout | 2013 | World Journal of Gastrointestinal Pharmacology and Therapeutics2013，4，4： | 4 |
| 2 | Emerging therapies for GERD 显示文摘 | Vander-Pol R Benninga M A Smout A J | 2011 | J Pediatr Gastroenterol Nutr2011，53，2： | 1 |
| 3 | Reverse transcriptase activity and untranslated region sharing of a new RTE-like, non-long terminal repeat retrotransposon from the human blood fluke, Schistosoma japonicum显示文摘 | Laha T Brindley PJ Smout M J | 2002 | Int J Parasitol2002，32，9： | 1 |
| 4 | Isolation of cDNAs encoding secreted and transmembrane proteins from Schistosoma mansoni by a sig- nal sequence trap method 显示文摘 | Smyth D McManus DP Smout M J | 2003 | Infect Immun2003，71，5： | 1 |
| 5 | Randomized controlled trial of dexamphetamine maintenance for the treatment of methamphetamine dependence显示文摘 | Longo M Wickes W Smout M | 2010 | Addiction2010，105，1： | 1 |
| 6 | From time temperature integrator kinetics to time temperature integrator tol- erance levels : heat-treated milk 显示文摘 | CLAEYS W L SMOUT C VAN LOEY A M | 2004 | Biotechnology Progress2004，20，1： | 1 |
| 7 | Chemospecific alterations in duodenal perception and motor response in functional dyspepsia显示文摘 | Schwartz M P Samsom M Smout A J | 2001 | Am J Gastroenterol2001，96，9： | 1 |
| 8 | Randomized controlled trial of dexamphetamine maintenance for the treatment of methamphetamine dependence 显示文摘 | Longo M Wickes W Smout M Harrison S Cahill S White JM | 2010 | Addic- tion2010，105，1： | 1 |
| 9 | Prevalence of delayed gastric emptying in diabetic patients and relation ship to dyspeptic symptoms:a prospective study in unse lected diabetic patients显示文摘 | Samsom M Vermeijden JR Smout AJ | 2003 | Diabetes Care2003，26，11： | 1 |
| 10 | Weak and absent peristalsis显示文摘 | Smout A Fox M | 2012 | Neu- rogastroenterol Motil2012，24，1： | 1 |
| 11 | Isolation of cDNAs encoding secreted and transmembrane proteins from Schistosoma mansoni by a signal sequence trap method显示文摘 | Smyth D Mcmanus DP Smout M] | 2003 | Infect Immun2003，71，5： | 1 |
| 12 | Implementing integrated oceans management: Australia's south east regional marine plan (SERMP) and Canada' s eastern Scotian shelf integrated management (ESSIM) initiative显示文摘 | FOSTER E HAWARD M SMOUT S C | 2005 | Marine Policy2005，29，5： | 1 |
| 13 | The proper use of governance in inter- national relations显示文摘 | Smouts M C | 1998 | International Social Science Journal1998，50，155： | 1 |
| 14 | Weak and absent peristalsis 显示文摘 | Smout A Fox M | 2012 | Neurogastroenterol Motil2012，24，1： | 1 |
| 15 | Platelet function following acute cerebral ischemia显示文摘 | SMOUT J DYKER A CLEANTHIS M | 2009 | Angiology2009，60，3： | 1 |
| 16 | The proper use of governance in international relations 显示文摘 | Smouts M C | 1998 | International Social Sci- ence Journal1998，50，155： | 1 |
| 17 | Chemospecific alterations in duodenal perception and motor response in functional dyspepsia显示文摘 | SCHWARZ MP SAMSOM M SMOUT AJPM | 2001 | American J of Gastroenterology2001，96，： | 1 |
| 18 | Responses to gastric distention in functional dyspepsia显示文摘 | Alet GA Samsom M Roelofs JM Smout A J | 1998 | Gut1998，42，： | 1 |
| 19 | Chemospecific alterations in duodenal perception and motor responses in functional dyspepsia 显示文摘 | Schwartz MP Samsom M Smout AJ | 2001 | Am J Gastroenterol2001，96，： | 1 |
| 20 | Effects of a meal and bisacodyl on colonic motility in healthy volunteers and patients with slow-transit constipation 显示文摘 | De Schryver AM Samsom M Smout AI | 2003 | Dig Dis Sci2003，48，7： | 1 |
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