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| 1 | Distribution of pericellular matrix molecules in the temporomandibular joint and their chondroprotective effects against inflammation显示文摘The objectives of this study were to(1) determine the distribution and synthesis of pericellular matrix(PCM) molecules(collagen VI, collagen IV and laminin) in rat temporomandibular joint(TMJ) and(2) investigate the effects of PCM molecules on chondrocytes against inflammation in osteoarthritis. Four zones(fibrous, proliferating, mature and hypertrophic) of condylar cartilage and three bands(anterior, intermediate and posterior) of disc were analysed by immunohistochemistry for the presence of PCM molecules in rat TMJs. Isolated chondrocytes were pre-treated with PCM molecules before being subjected to interleukin(IL)-1β treatment to stimulate inflammation. The responses of the chondrocytes were analysed using gene expression, nitric oxide release and matrix metalloproteinase(MMP)-13 production measures. Histomorphometric analyses revealed that the highest areal deposition of collagen VI(67.4%), collagen IV(45.7%) and laminin(52.4%) was in the proliferating zone of TMJ condylar cartilage. No significant difference in the distribution of PCM molecules was noted among the three bands of the TMJ disc. All three PCM molecules were expressed intracellularly by chondrocytes cultured in the monolayer. Among the PCM molecules, pre-treatment with collagen VI enhanced cellular proliferation, ameliorated IL-1β-induced MMP-3, MMP-9, MMP-13 and inducible nitric oxide synthase gene expression, and attenuated the downregulation of cartilage matrix genes, including collagen I, aggrecan and cartilage oligomeric matrix protein(COMP). Concurrently, collagen VI pretreatment inhibited nitric oxide and MMP-13 production. Our study demonstrates for the first time the distribution and role of PCM molecules, particularly collagen VI, in the protection of chondrocytes against inflammation. | Wern Cui Chu Shipin Zhang Timothy J Sng Yu Jie Ong Wen-Li Tan Vivien Y Ang Casper B Foldager Wei Seong Toh | 2017 | International Journal of Oral Science2017，9，1： | 5 |
| 2 | The relationship between body mass index and physical activity levels in relation to bone mineral density in premenopausal and postmenopausal women 显示文摘 | Wee J Sng BY Shen L | 2013 | Arch Osteoporos2013，8，： | 1 |
| 3 | The prevalence of BRCA1 mutations in Chinese patients with early onset breast cancer and affected relatives显示文摘 | Sng JH Chang J Feroze F | 2000 | Br J Cancer2000，82，3： | 1 |
| 4 | Condensing osteitis of the medial clavicle-an intermediate-term follow-up 显示文摘 | Sng KK Chart BK Chakrabarti A J | 2004 | Ann Acad Med Singapore2004，4，： | 1 |
| 5 | Production Coal and DryBiomass a Technology Review From 1950 to 2009 显示文摘 | Kopyscinski of Synthetic J Schildhauer Natural Gas T J Biollaz (SNG) From S | 2010 | Fuel2010，89，17： | 1 |
| 6 | The prevalence of BRCA1 mutations in Chinese patients with early onset breast cancer and affected relatives显示文摘 | Sng JH Chang J Feroze F | 2000 | Br J Cancer2000，82，： | 1 |
| 7 | Molecular cloning and characterization of the human topoisomerase II alpha and II beta genes:Evidence for isoform evolution through gene duplication显示文摘 | Sng J H Heaton V J Bell M | 1999 | Biochim Biophys Acta1999，1444，： | 1 |
| 8 | Emerging roles of angiopoietin-like 4 in human cancer显示文摘 | Tan M J Teo Z Sng M K | 2012 | Mol Cancer Res2012，10，6： | 1 |
| 9 | Surgical treatment of angle-closure glaucoma显示文摘 | CHEW P SNG C AQUINO MC SEE J | 2012 | Dev Ophthalmol2012，50，2： | 1 |
| 10 | The prevalence of BRCA1 mutations in Chinese patients with early onset breast cancer and affected relatives显示文摘 | SNG J H CHANG J FEROZE F | 2000 | Br J Cancer2000，82，3： | 1 |
| 11 | Knowledge, attitudes and practices of the advance medical directive in a residential estate in singapore显示文摘 | Tay M Chia S E Sng J | 2010 | Ann Acad Med Singapore2010，39，6： | 1 |
| 12 | Skin cancer trends among Asians living in Singapore from 1968 to 2006 显示文摘 | Sng J Koh D Siong WC | 2009 | J Am Acad Dermatol2009，61，3： | 1 |
| 13 | Synthesis and Water-swelling of Thermo-responsive Poly(ester urethane)s Containing Poly(epsilon-caprolactone), Poly(ethylene glycol) and Poly(propylene glycol) 显示文摘 | Loh X J Sng K B C Li J | 2008 | Biomaterials2008，29，22： | 1 |
| 14 | A novel communication strategy for decontrolled control of paralleled multi-inverter systems 显示文摘 | Cheng Y J Sng E K K | 2006 | IEEE Transactions on Power Electronics2006，21，1： | 1 |
| 15 | A novel communication strategy for decentralized control of paralleled multi- inverter systems 显示文摘 | Yeong J C Sng E K K | 2006 | IEEE Transactions on Power Electronics2006，21，1： | 1 |
| 16 | Histone modifications in kainate-induced status epilepticus显示文摘 | Sng J C Taniura H Yoneda Y | 2006 | Eur J Neurosci2006，23，5： | 1 |
| 17 | The prevalence of BRCA1 mutations in Chinese patients with early onset breast cancer and affected relatives显示文摘 | Sng JH Chang J Feroze F | | 0，，03： | 1 |
| 18 | The effect of hypothesis framing,prior expectations and cue diagnosticity on auditors'information choice, accounting 显示文摘 | Trotman K T Sng J | 1989 | Organizations and Society1989，14，： | 1 |
| 19 | Pretreatment anterior segment imaging during acute primary angle closure: insights into angle closure mechanisms in the acute phase显示文摘 | Sng CC Aquino MC Liao J | 2014 | Ophthalmology2014，121，1： | 1 |
| 20 | The prevalence of BRCA1 mutations in Chinese patients with early onset breast cancer and affected relatives显示文摘 | Sng JH Chang J Feroze F | 2000 | Br J Cancer2000，82，3： | 1 |
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