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| 1 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 2 | Analytical methods for detection of selected estrogenic compounds in aqueous mixtures 显示文摘 | Snyder S A Keith T L Verbrugge D A | 1999 | Environ Sci Technol1999，33，16： | 2 |
| 3 | The avian influenza virus nucleoprotein gene and a specific constellation of avian and human virus polymerase genes each specify attenuation of avian-human influenza A/ Pintail/79 reassortant viruses for monkeys 显示文摘 | Snyder M H Buckler-White A J London W T | | J Virol0，61，： | 1 |
| 4 | A Necessary And Sufficient Con- dition For Quantization Errors To Be Uniform And White 显示文摘 | Sripad A B Snyder D L | 1977 | IEEE Transactions on Acoustics Speech Signal Pro- cessing1977，25，3： | 1 |
| 5 | Nested electrodes for metal-arc welding显示文摘 | SNYDER A W | 1951 | Welding Journal1951，30，11： | 1 |
| 6 | Experiments on the stability of spiral flow at low axial Reynolds numbers 显示文摘 | Snyder H A | 1962 | Proceedings of the royal society of London A1962，265，： | 1 |
| 7 | Involvement in sports and psychological well-being显示文摘 | Snyder E E Spreitzer E A | 1974 | International Journal of Sport Psychology1974，，5： | 1 |
| 8 | Two-photon-excited fluorescence imaging of human RPE cells with a femtosecond Ti: Sapphire laser显示文摘 | Bindewald-Wittich A Han M Schmitz-Valckenberg S Snyder Sar- ah R Giese G Bille Josef F | 2006 | Invest Ophthalmol Vis Sci2006，47，10： | 1 |
| 9 | Pharmaceuticals,personal care products,and endocrine disruptors in water:Implications for the water industry显示文摘 | Snyder S A Westerhoff P Yoon Y | 2003 | Environmental Engineering Science2003，20，5： | 1 |
| 10 | Technology and Higher Education:The Impact of E-Learning Approaches on Student Academic Achievement,Perceptions and Persistence显示文摘 | Nora A Snyder B P | | 0，，： | 1 |
| 11 | Tribology of water and oil repellent sol-gel coatings for optical applications显示文摘 | KESSMAN A HUCKABY D SNYDER C | 2009 | Wear2009，267，1： | 1 |
| 12 | Physiological changes in male competitive cyclists after two weeks of intensified training显示文摘 | JEUKENDRUP A E HESSELINK MKC SNYDER A C | 1992 | Int J Sports Med1992，13，： | 1 |
| 13 | Modified iterative methods for consistent linear system显示文摘 | GUNAWARDENA A D JAIN S K SNYDER L | 1991 | Linear Algebra and Its Applications1991，154，1： | 1 |
| 14 | Reevaluation of PbTel -xlx as High Performance n-type Thermoelectric material 显示文摘 | LaLonde A D Pei Y Snyder G J | 2011 | Energy & Envi- ronmental Science2011，4，6： | 1 |
| 15 | Nanofiltra- tion and ultrafiltration of endocrine disrupting compounds, pharma- ceuticals and personal care products 显示文摘 | Yeomin Yoon Paul Westerhoff Shane A Snyder | 2006 | Joumal of Membrane Sci- ence2006，270，12： | 1 |
| 16 | The Effects of Titanium on Submerged Arc Weld Metal显示文摘 | SNYDER J P PENSE A W | 1982 | Welding Journal1982，61，7： | 1 |
| 17 | Infinite-horizonmodels for inventory control under yield uncertaintyand disruptions 显示文摘 | SCHMITT A J SNYDER L V | 2012 | Computers & OperationsResearch2012，39，4： | 1 |
| 18 | Protected paste volume in concrete exten- sion to internal curing using saturated lightweight fine aggregate显示文摘 | BENTZ D P SNYDER K A | 1999 | Cement and Concrete Research1999，，29： | 1 |
| 19 | The Role of Procalcitonin in Commmunity- Acquied Pneumonia: a literature review 显示文摘 | Lee M Snyder A | 2012 | Adv Emerg Nurs J2012，34，3： | 1 |
| 20 | Mierofibrillated cellulose new cellulose product : properties, uses, and commercial potential 显示文摘 | Turbak A Snyder F W Sandberg K R | 1983 | Journal of Applied Polymer Science: Applied Polymer Symposium1983，37，2： | 1 |
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