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| 1 | Interleukin-6-174G/C polymorphism is associated with a decreased risk of type 2 diabetes in patients with chronic hepatitis C virus显示文摘BACKGROUND Chronic hepatitis C(CHC)is associated with type 2 diabetes mellitus.Although the pathogenesis remains to be elucidated,a growing evidence has suggested a role of pro-inflammatory immune response.Increased serum concentrations of Interleukin 6(IL-6)have been associated with insulin resistance,type 2 diabetes mellitus as well as advanced forms of liver disease in chronic hepatitis C infection.AIM To investigate the frequency of IL-6-174G/C(rs1800795)single nucleotide polymorphism(SNP)in CHC patients and in healthy subjects of the same ethnicity.Associations between type 2 diabetes mellitus(dependent variable)and demographic,clinical,nutritional,virological and,IL-6 genotyping data were also investigated in CHC patients.METHODS Two hundred and forty-five patients with CHC and 179 healthy control subjects(blood donors)were prospectively included.Type 2 diabetes mellitus was diagnosed according to the criteria of the American Diabetes Association.Clinical,biochemical,histological and radiological methods were used for the diagnosis of the liver disease.IL-6 polymorphism was evaluated by Taqman SNP genotyping assay.The data were analysed by logistic regression models.RESULTS Type 2 diabetes mellitus,blood hypertension and liver cirrhosis were observed in 20.8%(51/245),40.0%(98/245)and 38.4%(94/245)of the patients,respectively.The frequency of the studied IL-6 SNP did not differ between the CHC patients and controls(P=0.81)and all alleles were in Hardy-Weinberg equilibrium(P=0.38).In the multivariate analysis,type 2 diabetes mellitus was inversely associated with GC and CC genotypes of IL-6-174(OR=0.42;95%CI=0.22-0.78;P=0.006)and positively associated with blood hypertension(OR=5.56;95%CI=2.79-11.09;P<0.001).CONCLUSION This study was the first to show that GC and CC genotypes of IL-6-174 SNP are associated with a decreased risk of type 2 diabetes mellitus in patients chronically infected with hepatitis C virus.The identification of potential inflammatory mediators involved in the crosstalk between hepatitis C virus and the axis pancreas-liver remains important issues that deserve further investigations. | Cliviany Borges da Silva Diego Alves Vieira Luisa Freitas de Melo Anna Luiza Soares Chagas Adriana Dias Gomes César Lúcio Lopes de Faria Jr Rosangela Teixeira Dulciene Maria de Magalh?es Queiroz Gifone Aguiar Rocha Maria Marta Sarquis Soares Juliana Maria Trindade Bezerra Luciana Diniz Silva | 2020 | World Journal of Hepatology2020，12，4： | 2 |
| 2 | Photolu minescence and thermoanalytical studies of complexes based on 5-C1-8- hydroxyquinoline and calix arene ligands 显示文摘 | Marcos N Soares Jr Elder F | 2013 | Materials Science and Engineering C2013，，： | 1 |
| 3 | Short-term use of estradiol for depression in perimenopausal and postmenopausal women: a preliminary report显示文摘 | Cohen LS Soares CN Poitras JR | 2003 | Am J Psychiatry2003，160，： | 1 |
| 4 | Carotid atheroma rupture observed in vivo and FSI-predicted stress distribution based on pre-rupture imaging显示文摘 | Leach JR Rayz VL Soares B | | 0，，08： | 1 |
| 5 | In silico struc- ture-function analysis of pathological variation in the HSD 11 B2 gene sequence 显示文摘 | Manning JR Bailey MA Soares DC | 2010 | Physio] Genomics2010，42，3： | 1 |
| 6 | Increment in hCG in the48- hperiodpriortotreatment: a new variable predictive of therapeuticsuccess treatment of eetopic pregnancy with methotrexate 显示文摘 | Da Costa Soares R Elito J Jr Camano L | 2008 | ArchGynecol Ob- stet2008，278，4： | 1 |
| 7 | Supraomohyoid neck dissection in the treatment of T1/T2 squamous ceU carcinoma of oral cavity显示文摘 | Kligerman J Lima RA Soares JR | 1994 | Am J Surg1994，168，5： | 1 |
| 8 | Endometrial thickness as an orienting factor for the medical treatment of unruptured tubal pregnancy显示文摘 | Da Costa Soares R Elito J Jr Han KK | 2004 | Acta Obstet Gynaecol Scand2004，83，3： | 1 |
| 9 | Increment in beta-hCG in the 48-h period prior to treatment:a new variable predictive of therapeutic success in the treatment of ectopic pregnancy with methotrexate显示文摘 | da Costa Soares R Elito J Jr Camano L | 2008 | Arch Gynecol Obstet2008，278，4： | 1 |
| 10 | Testicular histopathological diagnosis as a predictive factor for retrieving spermatozoa for ICSI in non-obstructive azoospermic patients显示文摘 | Glina S Soares JB Antunes N Jr | 2005 | Int Braz J Urol2005，31，： | 1 |
| 11 | Supraomohyoid neck dissection in the treatment of T1/T2 squamous cell carcinoma of oral cavity 显示文摘 | Kligerman J Lima RA Soares JR | 1994 | Am J Surg1994，168，5： | 1 |
| 12 | Co-continuous morphologies in polystyrene/ethylene-vinyl acetate blends:the influence of the processing temperature显示文摘 | ANA CRISTINA F MOREIRA FRANCISCO O CARIO JR BLUMA G SOARES | 2003 | Journal of Applied Polymer Science2003，89，： | 1 |
| 13 | Short-term use of estradiol for depression inperimenopausal and postmenopausal womem a preliminary report 显示文摘 | Cohen LS Soares CN Poitras JR | 2003 | American Journal of Psychiatry2003，160，8： | 1 |
| 14 | Optimizing the levels of feeding stimulants for use in high-fish meal and plant feedstuff-based diets for striped bass,Morone saxatilis 显示文摘 | Papatryphon E Soares Jr J H | 2001 | Aquaculture2001，202，： | 1 |
| 15 | The effect of phytase on apparent digestibility of four practical plant feedstuffs fed to striped bass, Morone saxatilis 显示文摘 | PAPATRYPHON E SOARES J H Jr | 2001 | Aquaculture Nutrition2001，7，： | 1 |
| 16 | Estrogen effects on pilocarpine-induced temporal lobe epilepsy in rats显示文摘 | Pereira M Jr Soares JM Jr Valente SG | 2009 | Maturitas2009，62，2： | 1 |
| 17 | Quantitative dietary threonine requirement of juvenile striped bass(Morone saxatilis)显示文摘 | Small B C Soares J H Jr | 1999 | Journal of the World Aquaculture Society1999，30，： | 1 |
| 18 | Supraomohyoid neck dissection in the treatment of T1/T2 squamous cell carcinoma of oral cavity显示文摘 | Kligerman J Lima RA Soares JR | 1994 | Am J Surg1994，168，5： | 1 |
| 19 | What is the in- fluence of hormone therapy on homocysteine and crp levels in postmenopausal women 显示文摘 | Lakryc EM Machado RB Soares Jr JM | 2015 | Clinics ( Sao Paulo )2015，70，2： | 1 |
| 20 | The effect of dietary feeding stimulants on growth performance of striped bass, Morone saxatilis,fed-a-plant feedstaff-based diet显示文摘 | Papatryphon E Soares Jr J H | 2000 | Aquaculture2000，185，： | 1 |
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