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| 1 | Pathogenesis and clinical management of Helicobacter pylori gastric infection显示文摘Helicobacter pylori(H.pylori)is a gram-negative bacterium that infects approximately 4.4 billion individuals worldwide.However,its prevalence varies among different geographic areas,and is influenced by several factors.The infection can be acquired by means of oral-oral or fecal-oral transmission,and the pathogen possesses various mechanisms that improve its capacity of mobility,adherence and manipulation of the gastric microenvironment,making possible the colonization of an organ with a highly acidic lumen.In addition,H.pylori presents a large variety of virulence factors that improve its pathogenicity,of which we highlight cytotoxin associated antigen A,vacuolating cytotoxin,duodenal ulcer promoting gene A protein,outer inflammatory protein and gamma-glutamyl transpeptidase.The host immune system,mainly by means of a Th1-polarized response,also plays a crucial role in the infection course.Although most H.pylori-positive individuals remain asymptomatic,the infection predisposes the development of various clinical conditions as peptic ulcers,gastric adenocarcinomas and mucosa-associated lymphoid tissue lymphomas.Invasive and non-invasive diagnostic methods,each of them with their related advantages and limitations,have been applied in H.pylori detection.Moreover,bacterial resistance to antimicrobial therapy is a major challenge in the treatment of this infection,and new therapy alternatives are being tested to improve H.pylori eradication.Last but not least,the development of effective vaccines against H.pylori infection have been the aim of several research studies. | Breno Bittencourt de Brito Filipe Ant?nio Fran?a da Silva Aline Silva Soares Vinícius Afonso Pereira Maria Luísa Cordeiro Santos Mariana Miranda Sampaio Pedro Henrique Moreira Neves Fabrício Freire de Melo | 2019 | World Journal of Gastroenterology2019，25，37： | 84 |
| 2 | Fetal brain tumors:Prenatal diagnosis by ultrasound and magnetic resonance imaging显示文摘Congenital central nervous system tumors diagnosed during pregnancy are rare, and often have a poor prognosis. The most frequent type is the teratoma. Use of ultrasound and magnetic resonance image allows the suspicion of brain tumors during pregnancy. However, the definitive diagnosis is only confirmed after birth by histology. The purpose of this mini-review article is to describe the general clinical aspects of intracranial tumors and describe the main fetal brain tumors. | Herbene Jose Milani Edward Araujo Junior Sergio Cavalheiro Patrícia Soares Oliveira Wagner Jou Hisaba Enoch Quindere Sa Barreto Maurício Mendes Barbosa Luciano Marcondes Nardozza Antonio Fernandes Moron | 2015 | World Journal of Radiology2015，7，1： | 7 |
| 3 | Effects of propolis from Brazil and Bulgaria on fungicidal activity of macrophages against Paracoccid-ioides brasiliensis 显示文摘 | Murad JM Calvi SA Soares AM | 2002 | Ethnopharmacol2002，79，3： | 1 |
| 4 | Metalloproteinases shed TREM-1 ectodomain from lipopolysaccharide-stimulated human monocytes显示文摘 | Gómez PV Soares SA Rodríguez RA | | 0，，06： | 1 |
| 5 | Donepezil: An Important Prototype to the Design of New Drug Candidates for Alzheimerμs Disease显示文摘 | Maria Cecilia Rodrigues Simoes Flavia Pereira Dias Viegas Marcella Soares Moreira Matheus de Freitas Silva Mariana Maximo Riquiel Patricia Mattos da Rosa Maísa Rosa Castelli Marcelo Henrique dos Santos Marisi Gomes Soares Claudio Viegas | 2014 | Mini-Reviews in Medicinal Chemistry2014，，1： | 1 |
| 6 | Interaction of human salivary mucin MG2, its recombinant N - terminal region and a synthetic pep- tide with Actinobacillus actinomycetemcomitans 显示文摘 | Liu B Rayment SA Soares RV | 2002 | J Periodontal Res2002，37，6： | 1 |
| 7 | Impact of ocean warming and ocean acidification on larvaldevelopment and calcification in the sea urchin Tripneustesgratilla显示文摘 | Sheppard Brennand H Soars N Dworjanyn SA | 2010 | PLoS One2010，5，11： | 1 |
| 8 | Effects of ABCA1 SNPs, including the C-105T novel variant, on serum lipids of Brazilian individuals显示文摘 | Genvigir FD Soares SA Hirata MH | 2008 | Clin Chim Acta2008，389，12： | 1 |
| 9 | Effects of ABCA1 SNPs,including the C -105T novel variant,on serum lipids of Brazilian individuals 显示文摘 | Genvigir FD Soares SA Hirata MH | 2008 | Clin Chim Acta2008，389，12： | 1 |
| 10 | Comparison of agar gel immunodiffusion test, rapid slide agglutination test, microbio- logical culture and PCR for the diagnosis of canine brucellosis 显示文摘 | Keid LB Soares RM Vasconcellos SA | 2009 | Res Vet Sci2009，86，1： | 1 |
| 11 | Risk factors for computer visual syndrome (CVS) among operators of two call centers in S?o Paulo, Brazil显示文摘 | Marcelo M. Soares Karen Jacobs Eduardo Costa Sa Mario Ferreira Junior Lys Esther Rocha | 2012 | Work (Supplement )2012，，1： | 1 |
| 12 | Pulmonary disease in patients with AIDS: hish resolution CT and pathologic findings显示文摘 | Marchiori E Muller NL Soares SA | 2005 | AJR Am J Roentgenol2005，184，： | 1 |
| 13 | An assessment of UDP-glucuronosyltransferase induction using prima- ry human hepatocytes显示文摘 | Soars MG Petullo DM Eckstein JA Kasper SC Wdghton SA | 2004 | Drug Metab Dispos2004，32，1： | 1 |
| 14 | Effects of propolis from Brazil and Bulgaria on fungicidal activity of macrophages against Paracoccidioides brasiliensis显示文摘 | Murad JM Calvi SA Soares AM | 2002 | Ethnopharmacol2002，79，3： | 1 |
| 15 | Metalloproteinases shed TREM- 1 ectodomain from lipopolysaccharide-stimulated human monocytes显示文摘 | Gomez PV Soares SA Rodriguez RA | 2007 | J Immunol2007，179，6： | 1 |
| 16 | Metalloproteinases shed TREM-1 ectodomain from lipopolysaccharide-stimulated human monocytes 显示文摘 | G6mez PV Soares SA Rodriguez RA | 2007 | Immunol2007，179，6： | 1 |
| 17 | Preva- lence and correlates of dizziness in community - dwelling older people: a cross sectional population based study 显示文摘 | De Moraes SA Soares WJ Ferriolli E | 2013 | BMC Geriatr2013，13，： | 1 |
| 18 | Diagno stic accu racy of sonohysterography,transvaginal sonography,and hystero salp ingography in patients with uterine cavity diseases显示文摘 | SOARES S R BARBO SA DO S REISMMB | 2000 | Fertil Steril2000，73，： | 1 |
| 19 | Continuous positive airway pressure increases inspiratory capacity of COPD patients显示文摘 | Soares SM Oliveira RA Franca SA | 2008 | Respirology2008，13，2： | 1 |
| 20 | Nitrogen removal in pond systems with different configurations and geometries显示文摘 | SILVA SA OLIVERIRA RD SOARES J | 1995 | Water Science and Technology1995，31，12： | 1 |
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