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| 1 | 双氢青蒿素哌喹复方治疗无并发症恶性疟的临床观察显示文摘 | 宋建平 Duong Socheat Suou Seila Thou Tharith SesS arim Sim Yutheasa 谈博 李国桥 | 2003 | 中华医学杂志2003，83，12： | 9 |
| 2 | 青蒿素哌喹片治疗间日疟62例临床报道显示文摘【目的】观察青蒿素哌喹片(Artequick)治疗间日疟的有效性、安全性及临床剂量。【方法】对62例间日疟患者采用成人总量4片Artequick 2 d疗程的给药方案治疗,观察近期治愈率、近期复发率以及平均原虫复燃天数等有效性指标,并评价其安全性。【结果】62例患者经治疗后临床症状较快缓解,平均原虫转阴时间为(60.7±23.9)h,平均退热时间为(14.1±7.8)h,其中54例完成28 d观察,近期治愈率为94.4%(51/54例),近期复发率为5.6%(3/54例)。本组病例对Artequick的耐受性良好,仅有少数病人出现恶心、呕吐;且为自限性;比较服药前与服药后第7天的血液、生化、心电图等指标,未发现Artequick片有明显的毒性。【结论】青蒿素哌喹片治疗间日疟,具有高效、速效、副反应少等优点,值得临床推广应用。 | 邓长生 谈博 DUONG Socheat SUOU Seila 徐颖 欧凤珍 SRENG Sokunthea LEAP Sophorn NGET Nom 宋健平 | 2008 | 广州中医药大学学报2008，25，3： | 5 |
| 3 | 高度疟疾流行区快速控制疟疾试验显示文摘【目的】探索在高度疟疾流行区快速控制疟疾的策略与方法。【方法】2004-2005两年期间,选择柬埔寨石居省疟疾高度流行区及其周边地带作为灭源灭疟试验区,共62个自然村21 343人口。在对当地疟疾流行情况进行了细致调查的基础上, 采取三项主要灭源措施:①疟疾现症病人采用复方青蒿素(Artequick,ATQ)方案治疗,发热病人亦以此作假定性治疗;②儿童带虫率≥20%的17个村采用ATQ方案进行一次全民治疗;③儿童带虫率≥6%的27个村采用低剂量伯氨喹全民服药,每10 d 1次,连续6个月。组织村抗疟员执行以上灭源措施。监测17个疫源村的人群带虫率,每6个月监测1次。【结果】采取灭源措施2年后,儿童带虫率从55.8%下降为5.3%:其中恶性疟带虫率由37.0%下降为2.3%;间日疟加三日疟带虫率由 18.9%下降为3.0%;儿童恶性疟配子体带虫率由13.1%下降为1.2%。有8个村儿童恶性疟带虫率由采取措施前的平均46.5%下降至0。成人带虫率的改变与儿童带虫率改变相似,由46.5%降为6.3%;恶性疟带虫率由采取措施前的平均34.2%下降为 2.5%,间日疟加三日疟带虫率由12.3%降为3.8%。【结论】灭源灭疟法有别于以控制蚊媒为主的传统方法,是一种又快又省钱的新方法和新策略,可在较短时间内扭转疟疾的高度流行,直至彻底消灭疟疾,值得在广大高疟区推广应用。 | 宋健平 Duong Socheat 谈博 Prak Dara 李海波 Sreng Sokunthea Suon Seila 欧凤珍 简华香 李国桥 | 2006 | 广州中医药大学学报2006，23，2： | 3 |
| 4 | 青蒿素哌喹片治疗无并发症恶性疟的剂量探索试验显示文摘目的探索青蒿素哌喹片治疗无并发症恶性疟的安全有效的适宜剂量。方法收治7~65岁男性和女性病人共100例,按区组随机化方案分成2组,成人总量1400 mg组年龄(22±s12)岁,1750 mg组年龄(21±12)岁。分别于0h和24h给药一次,比较2组的平均原虫转阴和退热时间、28d治愈率及原虫复燃率。结果2组的平均原虫转阴时间分别是(61±19)h和(57±21)h,平均退热时间为(20±15)h和(18±10)h,P>0.05;28 d治愈率是80%和96%,原虫复燃率为20%和4%,总量1750 mg组显著优于1400 mg组(P<0.05)。2组耐受性均良好,未发现明显的不良反应。结论推荐青蒿素哌喹片的临床治疗剂量为总量1750 mg,每日1次,分2d服完为1个疗程。 | 宋健平 谈博 DUONG Socheat SUOU Seila 徐颖 欧凤珍 SRENG Sokunthea LEAP Sophorn 李国桥 | 2008 | 中国新药与临床杂志2008，27，12： | 2 |
| 5 | Access to ar -te- misinin combination therapy fbr malaria in remote areas of Cam - bodia显示文摘 | YEUNG S VAN DAMME W SOCHEAT D | 2008 | Malar J2008，7，1： | 1 |
| 6 | Application of dipstick dye immunoassay (DDIA) kit for the diagnosis of schistosomiasis mekongi显示文摘 | Zhu Yc Socheat D Bounlu K | 2005 | Acta Trop2005，96，23： | 1 |
| 7 | Application of dipstick dye immunoassay (DDIA) kit for the diagnosis of schistosomiasis mekongi显示文摘 | Zhu Y C Socheat D Bounlu K | 2005 | 96 (2-3):137-412005，96，23： | 1 |
| 8 | Major pitfalls in the measurement of artemisinin derivatives in plasma in clinical studies显示文摘 | N. Lindegardh W. Hanpithakpong B. Kamanikom P. Singhasivanon D. Socheat P. Yi A.M. Dondorp R. McGready F. Nosten N.J. White N.P.J. Day | | Journal of Chromatography B0，，： | 1 |
| 9 | Artemisinin-resistant malaria in Asia显示文摘 | Noedl H Socheat D Satimai W | 2009 | New England J of Med2009，361，5： | 1 |
| 10 | Pyronaridine-artesunate versus chloroquine in patients with acute Plasmodiumvivax malaria:a randomized,double-blind,non-inferiority trial显示文摘 | Poravuth Y Socheat D Rueangweerayut R | 2011 | PLoS One2011，6，14： | 1 |
| 11 | Rapid and effective malaria control in Cambodia through mass administration of artemisinin-piperaquine显示文摘 | Song JP Socheat D Tan B | 2010 | Malaria Journal2010，9，： | 1 |
| 12 | Application of dipstick dye immunoassay (DDIA) kit for the diagnosis of schistosomiasis mekongi显示文摘 | Zhu YC Socheat D Bounlu K | | 0，，2： | 1 |
| 13 | Application of dipstick dye immunoassay (DDIA) kit for the diagnosis of schistosomiasis mekongi显示文摘 | Zhu YC Socheat D Bounlu K | 2005 | Acta Tropica2005，96，： | 1 |
| 14 | Evaluation of Selected Chemical,Biological Fungicides,and Induced Resistance to Control White Rot(Sclerotium rolfsii Sacc.)on Tomato显示文摘Tomato(Solanum lycopersicum)is one of the most widely grown and consumed as fresh vegetable in the world.Sclerotium rolfsii Sacc.is one of the most destructive diseases and affects more than 500 plant species.This study was conducted for“Evaluation of Selected Chemical,Biological Fungicides,and Induced Resistant to Control White Rot(Sclerotium rolfsii Sacc.)on Tomato”.The experiment was conducted at the Royal University of Agriculture and divided into two sections.The first section conducted under in vitro condition consists of four treatments T1 control treatment,T2 copper hydroxide,T3 azoxystrobin+difenoconazole,T4 metalaxyl+mancozeb in Nagoya Laboratory,and had been starting from 11st May to 15th May 2020.Section two was conducted in a pot in net-house which started from 1st January 2019 to 19th February 2019 and 1st January to 19th February 2020 and arranged in RCBD(Randomized Completely Block Design)with six replications and nine treatments.T0 negative control,T1 inoculate but not treatment,T2 metalaxyl+mancozeb,T3 azoxystrobin+difenoconazole,T4 copper hydroxide,T5 acibenzolar-S-methyl,T6 chicken dung+Trichoderma harzianum,T7 acibenzolar-S-methyl+chicken dung+Trichoderma harzianum,T8 acibenzolar-S-methyl+metalaxyl+mancozeb.Data were collected on colonizing diameter in vitro.For pot experiment collected on disease incidence,incubation period Based on the result under in vitro condition metalaxyl+mancozeb highly inhibited germination of Sclerotium rolfsii when compared with another treatment.However,the application of copper hydroxide seems less effective compared with control.For in pot experiment,when treated after symptom of southern blight appeared to seem less effective on the severity of southern blight.In contrast,when applied as a protectant and curative when symptoms appeared only systemic fungicide azoxystrobin+difenoconazole significantly reduced the severity of Sclerotium rolfsii and delayed incubation period while compared with other treatments(p<0.05)and was followed by metalaxyl+mancozeb,whereas,copper hydroxide,acibenzolar-S-methyl,chicken dung+Trichoderma harzianum,acibenzolar-S-methyl+chicken dung+Trichoderma harzianum,acibenzolar-S-methyl+metalaxyl+mancozeb were less effective(p>0.05).Based on the three experiments we can assume that fungicide is more effective in reducing the growth of the pathogen and delaying the incubation period of fungal colonization when compared with biological control and induced resistance. | Penghaing Ly Kim Eang Tho RabyNget Socheath Ong Chanthin Ouk Savry Poeng Phanta Seng Theary Leng Socheat Chheum | 2022 | Journal of Environmental Science and Engineering(A)2022，11，2： | 0 |
| 15 | 胶体染料试纸条法(DDIA)诊断湄公血吸虫病的研究显示文摘目的 评价胶体染料试纸条法诊断湄公血吸虫病的应用价值。方法 制备以日本血吸虫虫卵可溶性抗原为抗原的胶体染料试纸条试剂盒 (DDIA kit)。采用该试剂盒检测来自柬埔寨湄公血吸虫病流行区的 34例粪检阳性者和 170例粪检阴性者 ,近年来经吡喹酮治疗后不同年份的人群12 2例 ,以及 114例来自非血吸虫病流行区的健康人 ;同时对来自老挝湄公血吸虫病流行区的 70例粪检阳性者和 6 0例猫后睾吸虫感染者进行检测。对其中部分样本还采用日本血吸虫 SEA- EL ISA进行对照检测。结果 DDIA试剂盒检测湄公血吸虫病的敏感性为 97.1% (33/ 34,柬埔寨 )和98.6 % (6 9/ 70 ,老挝 ) ,与 EL ISA的检测结果相一致。对非流行区健康人的特异性为 10 0 .0 %。结论 日本血吸虫 DDIA试剂盒具有快速、简便、不需任何仪器设备等优点 。 | 朱荫昌 Duong Socheat Khanthong Bounlu 梁幼生 Muth Sinuon Sithat Insisiengmay 何伟 徐明 史伟珠 Nils Robert Bergquist | 2004 | 中国血吸虫病防治杂志2004，16，3： | 0 |
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