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| 1 | ICC density predicts bacterial overgrowth in a rat model of post-infectious IBS显示文摘AIM:To investigate the interstitial cells of Cajal(ICC) number using a new rat model.METHODS:Sprague-Dawley rats were assigned to two groups.The first group received gavage with Campylobacter jejuni(C.jejuni) 81-176.The second group was gavaged with placebo.Three months after clearance of Campylobacter from the stool,precise segments of duodenum,jejunum,and ileum were ligated in self-contained loops of bowel that were preserved in anaerobic bags.Deep muscular plexus ICC(DMP-ICC) were quantified by two blinded readers assessing the tissue in a random,coded order.The number of ICC per villus was compared among controls,Campylobacter recovered rats without small intestinal bacterial overgrowth(SIBO),and Campylobacter recovered rats with SIBO.RESULTS:Three months after recovery,27% of rats gavaged with C.jejuni had SIBO.The rats with SIBO had a lower number of DMP-ICC than controls in the jejunum and ileum.Additionally there appeared to be a density threshold of 0.12 DMP-ICC/villus that was associated with SIBO.If ileal density of DMP-ICC was < 0.12 ICC/villus,54% of rats had SIBO compared to 9% among ileal sections with > 0.12(P<0.05).If the density of ICC was < 0.12 DMP-ICC/villus in more than one location of the bowel,88% of these had SIBO compared to 6% in those who did not(P<0.001).CONCLUSION:In this post-infectious rat model,the development of SIBO appears to be associated with a reduction in DMP-ICC.Further study of this rat model might help understand the pathophysiology of postinfectious irritable bowel syndrome. | Sam-Ryong Jee Walter Morales Kimberly Low Christopher Chang Amy Zhu Venkata Pokkunuri Soumya Chatterjee Edy Soffer Jeffrey L Conklin Mark Pimentel | 2010 | World Journal of Gastroenterology2010，16，29： | 3 |
| 2 | Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis显示文摘 | Itin A Soffer L | 1992 | Nature1992，359，6398： | 1 |
| 3 | Impact of angina classon inhibition of platelet aggregation following clopidogrel loading in patients undergoing coronary intervention:Do we need more aggressive dosing regimens in unstable angina显示文摘 | Soffer D Moussa L Kishore J | 2003 | Catheterization and Cardiovascular Interventions2003，59，1： | 1 |
| 4 | Post-earnings Announcement Drift and the Dissemination of Predictable Information显示文摘 | Soffer L C T Lys | 1999 | Contemporary Accounting Research1999，，： | 1 |
| 5 | New challenges in information integration显示文摘 | HAAS L M SOFFER A | | 0，，： | 1 |
| 6 | Loss of intersti- tial cells of cajal and inhibitory innervation in insulin-de- pendent diabetes 显示文摘 | HE C L SOFFER E E FERRIS C' D | 2001 | Gastroenterology2001，121，2： | 1 |
| 7 | Manometric tests of anorectal function in healthy adults显示文摘 | Satish S.C Rao Renae Hatfield Edy Soffer Sheila Rao Jennifer Beaty Jeffrey L Conklin | 1999 | The American Journal of Gastroenterology1999，，3： | 1 |
| 8 | Ion sieving effects in the electrical double layer of porous carbon electrodes: Estimating ef- fective ion size in electrolytic solutions显示文摘 | ELIAD L SALITRA G SOFFER A | 2001 | J Phys Chem B2001，105，29： | 1 |
| 9 | Angiotensin-Converting Enzyme and the Regulation of Vasoactive Peptides显示文摘 | R L Soffer | 1976 | Annual Review of Biochemistry1976，，： | 1 |
| 10 | Angiotensin-converting enzyme and the regulation of vasoactive polypeptides显示文摘 | SOFFER R L | 1976 | Annu Rev Biochem1976，45，7： | 1 |
| 11 | Angiotensin2converting enzyme and the regulation of vasoactivepeptides显示文摘 | Richard L Soffer | 1976 | Annu Rev Biochem1976，45，： | 1 |
| 12 | Ion sieving effects in the electrical double layer of porous carbon electrodes: Estimating effective ion size in electrolytic solutions 显示文摘 | ELIAD L SALITRA G SOFFER A | 2001 | J Phys Chem B2001，105，29： | 1 |
| 13 | 显示文摘 | Soffer L Wang X Zhang X | 2008 | Journal of Biomaterials Science Polymer Edition2008，19，5： | 1 |
| 14 | Pan-colonic decrease in interstitial cells of Cajal in patients with slow transit constipation显示文摘 | He C L Soffer E | 2002 | Gut2002，51，4： | 1 |
| 15 | Silk-based electrospun tubular scaffolds for tissue-engineered vascular grafts显示文摘 | SOFFER L WANG X Y ZANG X H | 2008 | J Biomater Sci Polym Ed2008，19，5： | 1 |
| 16 | Impact of angina class on inhibition of platelet aggregation following clopidogrel loading in patients undergoing coronary intervention:Do we need more aggressive dosing regimens in unstable angina显示文摘 | Soffer D Moussa L Kishore J | 2003 | Catheterization and cardiovascular interventions2003，59，1： | 1 |
| 17 | Pan-colonic decrease in interstitial cells of Cajal in patients with slow transit constipation显示文摘 | LYFORD G L HE C L SOFFER E | 2002 | Gut2002，51，4： | 1 |
| 18 | Carbon electrodes for double-layer capacitors: ralation between ion and pore dimensions显示文摘 | Eliad L Salitra G Soffer A | 2001 | J Phys Chern B2001，105，： | 1 |
| 19 | 显示文摘 | Eliad L Salitra G Soffer A | 2002 | J Phys Chem B2002，106，10： | 1 |
| 20 | Ion sieving effects in the electrical double layer of porous carbon electrodes:Estimating effective ion size in electrolytic solutions显示文摘 | Eliad L Salitra G Soffer A | | 0，，29： | 1 |
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