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| 1 | Tumor necrosis factor-α and interleukin-6 in cirrhotic patients with spontaneous bacterial peritonitis显示文摘AIM:To evaluate the role of tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) in cirrhotic patients who have hepatic and renal impairment with spontaneous bacterial peritonitis(SBP).METHODS:We prospectively studied 120 cirrhotic patients with SBP and 80 cirrhotic patients with sterile ascitic fluid.They included 144 males and 56 females with ages ranging between 34 and 62 years.The diagnosis of cirrhosis was established by clinical and laboratory criteria that did not require histological confirmation.The severity of underlying liver disease was evaluated using Pugh's modification of Child's criteria(Child-Pugh scores).Ascitic fluid was sent to the laboratory for cell count,culture,sensitivity testing,and measurement of chemical elements(i.e.,albumin,glucose).Specimens were inoculated into aerobic and anaerobic blood culture bottles.Serum and ascitic fluid were also collected in sterile tubes at study entry(before the initiation of antibiotic treatment) and 48 h later.Assays for TNF-α and IL-6 in the serum and ascitic fluid were performed with an immunoenzymometric assay using manufacture's instructions.RESULTS:Cytokine levels in serum and ascitic fluid were significantly higher in the patients with SBP.(plasma TNF-α:135.35 ng/mL ± 11.21 ng/mL vs 92.86 ng/mL ± 17.56 ng/mL,P < 0.001;plasma IL-6:32.30 pg/mL ± 7.07 pg/mL vs 12.11 pg/mL ± 6.53 pg/mL,P < 0.001;ascitic fluid TNF-α:647.54 ± 107.11 ng/mL vs 238.43 ng/mL ± 65.42 ng/mL,P < 0.001);ascitic fluid IL-6:132.84 ng/mL ± 34.13 vs 40.41 ± 12.85 pg/mL,P < 0.001).About 48(40%) cirrhotic patients with SBP developed renal and hepatic impairment and showed significantly higher plasma and ascitic fluid cytokine levels at diagnosis of infection.[(plasma TNF-α:176.58 ± 17.84 vs 135.35 ± 11.21 ng/mL)(P < 0.001) and(IL-6:57.83 ± 7.85 vs 32.30 ± 7.07 pg/mL)(P < 0.001);ascitic fluid TNF-α:958.39 ± 135.72 vs 647.54 ± 107.11 ng/mL,(P < 0.001),ascitic fluid IL-6:654.74 ± 97.43 vs 132.84 ± 34.13 pg/mL,(P < 0.001)].Twenty nine patients(60.4%) with SBP and renal impairment died whereas,only four patients(5.55%) with SBP but without renal impairment died from gastrointestinal hemorrhage(P < 0.0005).CONCLUSION:It appears that TNF-α production may enhance liver cell injury and lead to renal impairment.This correlated well with the poor prognosis and significantly increased mortality associated with SBP in cirrhotic patients. | Muhammed AM Suliman Fawzy MH Khalil Salam SA Alkindi Anil V Pathare Ali AA Almadhani Neveen AAI Soliman | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，5： | 39 |
| 2 | Role of Diffusion-weighted MR Imaging in Cervical Lymphadenophathy显示文摘 | Abdel Razek AA Soliman NY Elkhamary S | 2006 | Eur Radiol2006，16，7： | 1 |
| 3 | Role of diffusion-weighted MR imaging in cervical lymphadenopathy显示文摘 | Abdel Razek AA Soliman NY Elkhamary S | 2006 | European Journal of Radiology2006，16，7： | 1 |
| 4 | Relationship of monoamine oxidase A binding to adaptive and maladaptive personality traits显示文摘 | Soliman A Bagby RM Wilson AA | 2011 | Psychol Med2011，41，5： | 1 |
| 5 | Role of diffusion-weighted MR imaging in cervical lymphadenopathy 显示文摘 | Abdel Razek AA Soliman NY Elkhamary S | 2006 | Eur Radiol2006，16，7： | 1 |
| 6 | Role of diffusion-weighted MR imaging in cervical lymphadenopathy 显示文摘 | Abdel Razek AA Soliman NY Elkhamary S | 2006 | Eur Radiol2006，16，7： | 1 |
| 7 | Standard achromatic perimetry, short wavelength automated perimetry, and frequency doubling technology for detection of glaucoma damage 显示文摘 | Soliman MA de Jong LA Ismaeil AA | 2002 | Ophthalmology2002，109，3： | 1 |
| 8 | Role of Diffusion-weighted MR Imaging in Cervical Lymphadenopathy显示文摘 | Abdel Razek AA Soliman NY Elkhamary S | 2006 | Eur Radiol2006，16，7： | 1 |
| 9 | Sonographic features of triple-negative and non-triple-negative breast cancer显示文摘 | Wojeinski S Soliman AA Schmidt J | 2012 | J Ultrasound Med2012，31，10： | 1 |
| 10 | Role of diffusion-weighted MR imaging in cervical lymphadenopathy 显示文摘 | Abdel Razek AA Soliman NY Elkhamary S Alsharaway MK Tawfik A | 2006 | Eur Radiol2006，16，7： | 1 |
| 11 | Treatment of human Demodex folliculorum by camphor oil and metronidazole显示文摘 | Hassan AA Soliman M | 2004 | J Egypt Soc Parasitol2004，34，1： | 1 |
| 12 | Role of diffusionweighted MR imaging in cervical lymphadenopathy 显示文摘 | Abdel Razek AA Soliman NY Elkhamary S | 2006 | Eur Radiol2006，16，7： | 1 |
| 13 | Role of diffusion-weighted MR imaging in cervical lymphadenopathy 显示文摘 | Abdel Razek AA Soliman NY Elkhamary S | 2006 | Eur Radiol2006，16，7： | 1 |
| 14 | Sonographic features of triple-negative and non-triple-negative breast eaneer显示文摘 | Wojeinski S Soliman AA Schmidt J | 2012 | J Ultrasound Med2012，31，10： | 1 |
| 15 | Sonographic features of tri-pie-negative and non- triple- negative breast cancer显示文摘 | Wojcinski S Soliman AA Schmidt J | 2012 | J Ultrasound Med2012，31，10： | 1 |
| 16 | Role of diffusion-weighted MR imaging in cervical lymphadenopathy显示文摘 | Abdel Razek AA Soliman NY Elkhamary S | 2006 | Eur Radiol2006，16，7： | 1 |
| 17 | Idiopathic intussusception; The role of laparoscopy显示文摘 | Hay SA Kabesh AA Soliman HA | | 0，，04： | 1 |
| 18 | Role of dif-fusion-weighted MR imaging in cervical lymphadenopathy显示文摘 | Abdel Razek AA Soliman NY Elkhamary S | 2006 | Eur Radiol2006，16，： | 1 |
| 19 | Role of diffusion-weighted MR imaging in cervical lymphadenopathy 显示文摘 | Abdel Razek AA Soliman NY Elkhamary S | 2006 | Eur Radiol2006，16，7： | 1 |
| 20 | Effect of propranolol on IL-10,visfatin,Hsp70,i NOS,TLR2,and survivin in amelioration of tumor progression and survival in Solid Ehrlich Carcinoma-bearing mice显示文摘 | Abdin AA Soliman NA Saied EM | 2014 | Pharmacol Rep2014，66，6： | 1 |
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