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| 1 | Association between thrombotic risk factors and extent of fibrosis in patients with non-alcoholic fatty liver diseases显示文摘AIM: To evaluate the prevalence of genetic and acquired prothrombotic risk factors and their association with the extent of fibrosis and fatty infiltration in patients with non-alcoholic fatty liver disease (NAFLD).METHODS: Forty-four patients with chronic hepatitis (28 men and 16 women, with mean age of 45±11 and 49±12 years, respectively) constituted the patient population of this study. The groups were divided as follows: 15 patients with fatty liver (FL); 15 with non-alcoholic steatohepatitis (NASH); 14 with chronic viral hepatitis (CH) diagnosed by histology and liver technetium scan or ultrasound; and 10 healthy individuals. Thrombophilic, coagulation factors and genetic mutations were diagnosed by standard hemostatic and molecular coagulation assays.RESULTS: Activated protein C (APC) resistance and protein S were the most prevalent thrombotic risk factors (6% and 10% in NAFLD vs 21% and 14% in CH; P<0.01 and P<0.05, respectively). One thrombotic risk factor was identified in 41% of patients (23% mild fibrosis, 18% severe fibrosis) and two thrombotic risk factors in 6% of patients with NAFLD and severe fibrosis. While no differences in APC ratio, lupus anticoagulant, fibrinogen, factor V Leiden,prothrombin, and MTHFR mutation were found. Protein S levels were significantly lower in NASH patients than in patients with FL alone (92±19 vs106±2, P<0.01). Protein C levels were markedly higher in patients with NAFLD and mild or severe fibrosis as compared to the patients with CH, respectively (128±40 vs96±14, P<0.001 or 129±36 vs 88±13, P<0.01).CONCLUSION: Up to 46% of patients with NAFLD may have thrombotic risk factors, and the presence of thrombotic risk factors is correlated with the extent of hepatic fibrosis,suggesting a crucial role of the coagulation system in the pathogenesis of hepatic fibrosis. | N Assy I Bekirov Y Mejritsky L Solomon S Szvalb O Hussein | 2005 | World Journal of Gastroenterology2005，11，37： | 3 |
| 2 | Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study显示文摘 | Julia Granerod Helen E Ambrose Nicholas WS Davies Jonathan P Clewley Amanda L Walsh Dilys Morgan Richard Cunningham Mark Zuckerman Ken J Mutton Tom Solomon Katherine N Ward Michael PT Lunn Sarosh R Irani Angela Vincent David WG Brown Natasha S Crowcroft | 2010 | The Lancet Infectious Diseases2010，，12： | 2 |
| 3 | Absorption of selenium from milk protein and isolated soy protein formulas in preschool children: studies using stable isotope tracer 74Se显示文摘 | SOLOMONS N W TORUN B JANGHORBANI M | 1986 | J Pediatr Gastroenterol Nutr1986，5，1： | 1 |
| 4 | Long-term outcomes in patientswith treated childhood hydrocephalus显示文摘 | Gupta N Park J Solomon C | 2007 | J Neurosurg2007，106，5： | 1 |
| 5 | Mycophenolate mofetil or intravenous cyclophosphamide for lupus nephritis with poor kidney function:a subgroup analysis of the Aspreva Lupus Management Study显示文摘 | Walsh M Solomons N Lisk L | | 0，，05： | 1 |
| 6 | Social Percolation Models 显示文摘 | Solomon S Weisbuch G De Arcangelis L Jan N Stauffer D | 2000 | Physica A2000，277，12： | 1 |
| 7 | Prevalence of stroke and strokerelated disability:estimates from the Auckland Stroke Studies显示文摘 | Bonita R Solomon N Broad J | 1997 | Stroke1997，28，： | 1 |
| 8 | Imaging spectrometry for earth remote sensing 显示文摘 | AGOETZ A F H SOLOMON G V J ROCK B N | 1985 | Science1985，228，： | 1 |
| 9 | Beta-cell specific expression of suppressor of cytokine signaling-1 ( SOCS-1 ) delays islet allograft rejection by down-regulating Interferon Regula- tory Factor-1 (IRF-1) signaling显示文摘 | Solomon M Flodsdtrom-Tullberg M Sarventnick N | 2011 | Transpl Immunol2011，24，3： | 1 |
| 10 | Friendship in high- functioning children with autism spectrum disorder: mixed and non-mixed dyads显示文摘 | Bauminger N Solomon M Aviezer A | 2008 | J Autism Dev Disord2008，38，7： | 1 |
| 11 | A review on current research trends in electrical discharge machining (EDM)显示文摘 | Abbas N M Solomon D G Bahari Md F | | 0，，7： | 1 |
| 12 | Effects of fi- brinogen concentrate as first-line therapy during major aortic replacement surgery显示文摘 | Rahe-Meyer N Solomon C Hanke A | 2013 | Anesthesiology2013，118，1： | 1 |
| 13 | Marketing percolation显示文摘 | J Goldenberg B Libai S Solomon N Jan D Stauffer | 2000 | Physica A: Statistical Mechanics and its Applications2000，，1： | 1 |
| 14 | Tectonic stress in the plates显示文摘 | Richardson R M Solomon S C Sleep N H | 1979 | Reviews of Geophysics1979，17，5： | 1 |
| 15 | A review on current researeh trends in electrical discharge machining (EDM) 显示文摘 | Abbas N M Solomon D G Fuad Bahari Md | 2007 | International Journal of Machine Tools and Manufacture2007，47，78： | 1 |
| 16 | Inactivation of Clostridium botulinum type A spores by high pressure processing at elevated temperatures显示文摘 | REDDY N R SOLOMON H M TEZLOFF R C | 2003 | Journal of Food Protection2003，66，6： | 1 |
| 17 | An emerging view of scientific collaboration : scientists ' perspectives on collabora- tion and factors that impact collaboration 显示文摘 | HARA N SOLOMON P KIM S L | 2003 | Journal of the A- merican Society for Information Science and Technology2003，54，10： | 1 |
| 18 | Competitive interaction of iron and zinc in the diet: consequences for human nutrition显示文摘 | | 1986 | Natr1986，116，： | 1 |
| 19 | Negative-pressure wound therapy Ⅰ:the paradox of negative-pressure wound therapy显示文摘 | Kairinos N Solomons M Hudson DA | 2009 | Plast Reconstr Surg2009，123，： | 1 |
| 20 | Nutritional problems in developing countries显示文摘 | Brown K H Solomons N W | 1998 | Infections Disease Clinics of North America1998，5，： | 1 |
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