| 1 | Association between moderately oxidized low-density lipoprotein and high-density lipoprotein particle subclass distribution in hemodialyzed and post-renal transplant patients显示文摘Disturbances in the metabolism of lipoprotein profiles and oxidative stress in hemodialyzed(HD) and post-renal transplant(Tx) patients are proatherogenic,but elevated concentrations of plasma high-density lipoprotein(HDL) reduce the risk of cardiovascular disease.We investigated the concentrations of lipid,lipoprotein,HDL particle,oxidized low-density lipoprotein(ox-LDL) and anti-ox-LDL,and paraoxonase-1(PON-1) activity in HD(n=33) and Tx(n=71) patients who were non-smokers without active inflammatory disease,liver disease,diabetes,or malignancy.HD patients had moderate hypertriglyceridemia,normocholesterolemia,low HDL-C,apolipoprotein A-I(apoA-I) and HDL particle concentrations as well as PON-1 activity,and increased ox-LDL and anti-ox-LDL levels.Tx patients had hypertriglyceridemia,hypercholesterolemia,moderately decreased HDL-C and HDL particle concentrations and PON-1 activity,and moderately increased ox-LDL and anti-ox-LDL levels as compared to the reference,but ox-LDL and anti-ox-LDL levels and PON-1 activity were more disturbed in HD patients.However,in both patient groups,lipid and lipoprotein ratios(total cholesterol(TC)/HDL-C,LDL-C/HDL-C,triglyceride(TG)/HDL-C,HDL-C/non-HDL-C,apoA-I/apoB,HDL-C/apoA-I,TG/HDL) were atherogenic.The Spearman's rank coefficient test showed that the con-centration of ox-LDL correlated positively with HDL particle level(R=0.363,P=0.004),and negatively with TC(R=?0.306,P=0.012),LDL-C(R=?0.283,P=0.020),and non-HDL-C(R=?0.263,P=0.030) levels in Tx patients.Mul-tiple stepwise forward regression analysis in Tx patients demonstrated that ox-LDL concentration,as an independent variable,was associated significantly positively with HDL particle level.The results indicated that ox-LDL and de-creased PON-1 activity in Tx patients may give rise to more mildly-oxidized HDLs,which are less stable,easily un-dergo metabolic remodeling,generate a greater number of smaller pre-β-HDL particles,and thus accelerate reverse cholesterol transport,which may be beneficial for Tx patients.Further studies are necessary to confirm this. | Elzbieta KIMAK Magdalena HALABI Iwona BARANOWICZ-GASZCZYK Janusz SOLSKI Andrzej KSIAZEK | 2011 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2011，12，5： | 5 |
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