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| 1 | Delayed diagnosis of alpha-1-antitrypsin deficiency following post-hepatectomy liver failure: A case report显示文摘Post-hepatectomy liver failure(PHLF) is a leading cause of morbidity and mortality following major liver resection. The development of PHLF is dependent on the volume of the remaining liver tissue and hepatocyte function. Without effective pre-operative assessment, patients with undiagnosed liver disease could be at increased risk of PHLF. We report a case of a 60-year-old male patient with PHLF secondary to undiagnosed alpha-1-antitrypsin deficiency(AATD) following major liver resection. He initially presented with acute large bowel obstruction secondary to a colorectal adenocarcinoma, which had metastasized to the liver. There was no significant past medical history apart from mild chronic obstructive pulmonary disease. After colonic surgery and liver directed neo-adjuvant chemotherapy, he underwent a laparoscopic partially extended right hepatectomy and radio-frequency ablation. Post-operatively he developed PHLF. The cause of PHLF remained unknown, prompting reanalysis of the histology, which showed evidence of AATD. He subsequently developed progressive liver dysfunction, portal hypertension, and eventually an extensive parastomal bleed, which led to his death; this was ultimately due to a combination of AATD and chemotherapy. This case highlights that formal testing for AATD in all patients with a known history of chronic obstructive pulmonary disease, heavy smoking, or strong family history could help prevent the development of PHLF in patients undergoing major liver resection. | Benjamin Norton Jemimah Denson Christopher Briggs Matthew Bowles David Stell Somaiah Aroori | 2016 | World Journal of Gastroenterology2016，22，11： | 3 |
| 2 | An improved synthesis of antiulcerative drug: tenatoprazole 显示文摘 | SOMAIAH S RAMACHANDRA RB VENUGOPAL RK | 2009 | Org Process Res Dev2009，13，4： | 1 |
| 3 | Antiangiogenic agents in the management of non-small cell lung cancer: where do we stand now and where are we headed? 显示文摘 | Aggarwal C Somaiah N Simon G | 2012 | Cancer Biol Ther2012，13，5： | 1 |
| 4 | An improved synthesis of antiulcerative drug: tenatoprazole 显示文摘 | Somaiah Sripathi Ramachandra Reddy Bojja Venugopal Reddy Kamati | 2009 | Organic Process Research & DevelOpment2009，13，4： | 1 |
| 5 | Magnetic and magnetoelastic properties of Zn-doped cobalt-ferrites—CoFe 2? x Zn x O 4 ( x =0, 0.1, 0.2, and 0.3)显示文摘 | Nalla Somaiah Tanjore V. Jayaraman P.A. Joy Dibakar Das | 2012 | Journal of Magnetism and Magnetic Materials2012，，14： | 1 |
| 6 | Carpal tunnel syndrome 显示文摘 | Somaiah A Roy AJ Spence | 2008 | Ulster Med J2008，77，1： | 1 |
| 7 | Antiangiogenic agents in the management of non-small cell lung cancer: where do we stand now and where are we headed 显示文摘 | Aggarwal C Somaiah N Simon G | 2012 | Cancer Biol Ther2012，13，5： | 1 |
| 8 | Edge effects on plant diversity in tropical forest ecosystems at Periyar Wildlife sanctuary in the Western Ghats of India显示文摘Forest resource conservation has been widely accepted as a key to sustain the local and regional economic development. The forest edges are affected by anthropogenic activities including deforestation, forest fragmentation, selective logging, extraction of non-timber forest products, collection of medicinal plants, recreations, hydroelectric projects and its associated developmental activities, which alter the biodiversity. The present study intends to evaluate the edge effect on vegetation structure and species compositions in the tropical forest ecosystems at Periyar Wildlife Sanctuary in the Western Ghats. High species richness (number of species) and Shannon's diversity indices were observed in the site Ⅲ (completely undisturbed forest) compared to site Ⅰ (adjacent to the village/ edge of the forest, which is next to the teak plantation, severely disturbed forest) and site Ⅱ (in between the undisturbed forest and moderately disturbed forest) while density of tree species showed greater value in site Ⅱ. Single species such as Tectona grandis (IVI of 80) and Terminalia paniculata (IVI of 112) were the dominant tree species in site Ⅰ and site II, respectively, whereas, in site Ⅲ Terminalia bellirica, Bishofia javanica and Syzgium gardneri shared the dominance. Perturbation leads to alien plant invasion particularly Lantana camara, Eupatorium odoratum and Ageratum conizoides. Site Ⅱ is at forest transition level because the site is dominated by both natural species as well as plantation species such as Tectona grandis. This site seems to be a buffer zone on natural forest and plantations. Further studies are required to analyse the real patterns of regeneration and dynamic change due to human impact by long term monitoring with the establishment of permanent plots. | Somaiah Sundarapandian Pascal J. Karoor | 2013 | Journal of Forestry Research2013，24，3： | 1 |
| 9 | Antiangiogenic agents in the management of non-small cell lung cancer:where do we stand now and where are we headed 显示文摘 | Aggarwal C Somaiah N Simon G | 2012 | Cancer Biol Ther2012，13，5： | 1 |
| 10 | A tabulated summary oftargeted and biologic therapies for non-small cell lung cancer显示文摘 | SOMAIAH N SIMON NG SIMON GR | 2012 | Thorac Oncol2012，16，5： | 1 |
| 11 | An improved synthesis of antiulcerative drug : tenatoprazole 显示文摘 | Somaiah Sripathi Ramachandra Reddy Bojja | 2009 | Organic Process Research & Development2009，13，： | 1 |
| 12 | Biomarkers with predictive and prognostic function in non-small cell lung cancer:ready for prime time显示文摘 | Aggarwal C Somaiah N Simon GR | 2010 | Natl Compr Canc Netw2010，8，7： | 1 |
| 13 | Human UBNl is an ortholog of yeast Hpc2p and has an essential role in the HIRA/ASFla ehromatin - remodeling pathway in senes- cent cells显示文摘 | Banumathy G Somaiah N Zhang R | 2009 | Mol Cell Biol2009，29，3： | 1 |
| 14 | An efficient and stereoselective synthesis of (3S,4R)-(-)-trans-4-(4'- fluorophenyl) -3 -hydroxymethyl -N -methylpiperidine 显示文摘 | Somaiah S Sashikanth S Raju V | 2011 | Tetrahedron: Asymmetry2011，22，： | 1 |
| 15 | Gastrointestinal stromal tumors in the setting of multiple tumor syndromes 显示文摘 | Burgoyne AM Somaiah N Sicklick JK | 2014 | Curr OpinOncol2014，26，4： | 1 |
| 16 | Antiangiogenic agents in themanagement of non-small cell lung cancer: where do we stand nowand where are we headed显示文摘 | Aggarwal C Somaiah N Simon G | 2012 | Cancer Biol Ther2012，13，5： | 1 |
| 17 | Evaluation of nilo- tinib in advanced GIST previously treated with imatinib and sunitinib 显示文摘 | Cauchi C Somaiah N Engstrom PF | 2012 | Cancer Chemother Pharmacol2012，69，4： | 1 |
| 18 | Use of negative thyroid transcription factor ( TTF-1 ) status to predict for negative epidermal growth factor receptor (EGFR) mutations ( Mts ) status with a high negative predictive value (NPV) in patients (pts) with adenocarcino- mas (AC) of the lung显示文摘 | Somaiah N Garrett-Mayer E Huang X | 2011 | J Clin Oncol2011，，： | 1 |
| 19 | Locoregional Disease Patterns in Well-Differentiated and Dedifferentiated Retroperitoneal Liposarcoma: Implications for the Extent of Resection?显示文摘 | William W. Tseng John E. Madewell Wei Wei Neeta Somaiah Alexander J. Lazar Markus P. Ghadimi Aviad Hoffman Peter W. T. Pisters Dina C. Lev Raphael E. Pollock | 2014 | Annals of Surgical Oncology2014，，7： | 1 |
| 20 | Biomarkers with predictive and prognostic function in non -small cell lung cancer: ready for prime time 显示文摘 | Aggarwal C Somaiah N Simon GR | 2010 | J Nat Compr Canc Netw2010，8，7： | 1 |
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