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| 1 | Significance of serum carcinoembryonic antigen in metastatic breast cancer patients:A prospective study显示文摘BACKGROUND Carcinoembryonic antigen(CEA)is an important serum tumour marker with a substantial role in diagnosis and monitoring of various solid tumours.About 36%-70%of breast cancers have elevated serum CEA.And the available studies show discrepancy in addressing the prognostic significance of CEA in advanced breast cancer.AIM To estimate the serum CEA level in our metastatic breast cancer patients and correlate it with response to treatment and clinical outcome.METHODS This was a prospective clinical study conducted on 50 metastatic breast cancer patients treated at breast clinic,with newly diagnosed metastatic breast cancer planned for palliative chemotherapy,targeted therapy,and hormonal treatment.We estimated the proportion of patients with elevated serum CEA level at baseline and after palliative treatment and also studied the association of serum CEA levels with known prognostic factors.The response to treatment was correlated with the serum CEA levels in the context of responders and nonresponders.RESULTS The median pre-treatment and post-treatment CEA levels were 7.9(1.8-40.7)ng/mL and 4.39(1.4-12.15)ng/mL,respectively,in the whole study population(P=0.032).No statistically significant difference was seen in baseline serum CEA between responders and non-responders.Even in the luminal group,pretreatment serum CEA was not a predictor of response,but post-treatment CEA was a significant predictor of tumour progression.In patients with liver and lung metastases,post-treatment CEA level difference was not statistically significant in both responders and non-responders though the values were higher in nonresponders.Among those with bone metastases,69.5%had elevated post-treatment serum CEA,and only 37.5%had elevated serum CEA in those with no bone metastases.CONCLUSION Elevated post-treatment serum CEA levels are associated with disease progression and poor response to therapy.Persistently elevated post-treatment serum CEA levels are significantly associated with bone metastases.Elevated serum CEA and hormonal status are significant predictors of treatment response. | Thattungal Manoharan Anoop Rona Joseph P Saikumar Soman Steffi Chacko Mintu Mathew | 2022 | World Journal of Clinical Oncology2022，13，6： | 2 |
| 2 | Least square estimation of three parameters of a weibull estimation显示文摘 | SOMAN K P MISRA K B | 1992 | Microelectronics and Reliability1992，32，3： | 1 |
| 3 | Three-dimensional solution structure of a single zinc finger DNA-binding domain显示文摘 | LEE M S GIPPERT G P SOMAN K V | 1989 | Science1989，245，4918： | 1 |
| 4 | Combined make-to-order and make-to-stock in a food production system 显示文摘 | SOMAN C A VAN DONK D P GAALMAN G | 2004 | International Journal of Production Economics2004，90，2： | 1 |
| 5 | Least Square Estimation of Three Parame-ters of a Weibull Estimation显示文摘 | Soman K P Misra K B | 1992 | Microelectronics and Reliability1992，32，3： | 1 |
| 6 | Power Doppler har- monicimaging:afeasibility study of a new technique for the as- sessment of myocardial perfusion 显示文摘 | SENIOR R KAUL S SOMAN P | 2000 | Am Heart2000，139，21： | 1 |
| 7 | Particulate allergens potentiate allergic asthma in mice through sustained IgE-mediated mast cell activation显示文摘 | Jin Cong Shelburne Christopher P Li Guojie Potts Erin N Riebe Kristina J Sempowski Gregory D Foster W Michael Abraham Soman N | 2011 | Journal of Clinical Investigation2011，，3： | 1 |
| 8 | Combined Make-to-order and Make-to-stock In a Food Production System显示文摘 | Soman C A Van Donk D P Gaalman G | 2004 | International Journal of Production Economics2004，90，2： | 1 |
| 9 | Linear phase paraunitary filter banks: theory, factorizations and designs显示文摘 | SOMAN A K VAIDYANATHAN P P NYUGEN T Q | 1993 | IEEE Transactions on Signal Processing1993，41，12： | 1 |
| 10 | Comparative effects of exercise training on transcription of antioxidant enzyme and the activity in old rat heart 显示文摘 | Soman S M Rybak L P | 1996 | Indian J Physiol Pharm aco1996，40，3： | 1 |
| 11 | Three-dimensional solution structure of a single zinc finger DNA-binding domain 显示文摘 | Lee M S Gippert G P Soman K V | 1989 | Science1989，245，： | 1 |
| 12 | Capacitated planning and scheduling for combinedmake-to-order and make-to-stock production in the food industry: An illustrative case study 显示文摘 | Soman C A van Donk D P Gaalman G J C | 2007 | IntJ Production Economics2007，108，： | 1 |
| 13 | Regression of left ventricular remolding in chronic heart failure:Comparative and combined effects of catopril and carvedilol显示文摘 | Khattar R S Senior R Soman P | 2001 | Am Heart J2001，142，4： | 1 |
| 14 | Power doppler harmonic imaging: a feasibility study of a new technique for the assessment of myocardial perfusion显示文摘 | SENIOR R KAUL S SOMAN P | 2000 | Am Heart J2000，139，21： | 1 |
| 15 | A least square estimation of three parameters of a weibull distribution显示文摘 | Soman K P Misra K B | 1992 | Micro- electronics Reliability1992，32，3： | 1 |
| 16 | Risks associated with renal dysfunction in patients in the coronary care unit显示文摘 | MECULLOUGH P A SOMAN S S SHAH S S | 2000 | J Am Coil Cardiol2000，36，： | 1 |
| 17 | A Three- dimensional polymer scaffolding material exhibiting a zero poisson's Ratio显示文摘 | Soman P Fozdar DY Lee JW | 2012 | Soft Matter2012，8，18： | 1 |
| 18 | Comparison of dynamic scheduling policies for hybrid make-to-order and make-to- stock production systems with stochastic demand显示文摘 | SOMAN C A VAN DONK D P GAALMAN G | 2006 | International Journal of Production Economics2006，104，5： | 1 |
| 19 | Safety of an intravenous second generation contrast agent in patients with severe left ventriculars function显示文摘 | Soman P Lahiri A Senior R | 2000 | Heart2000，84，6： | 1 |
| 20 | Selective tuning visual attention model显示文摘 | Amudha J Soman K P | 2009 | Intemational Journal of Recent Trends in Engi- neering2009，2，2： | 1 |
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