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| 1 | Overexpression of Rice Sphingosine-1-Phoshpate Lyase Gene OsSPL1 in Transgenic Tobacco Reduces Salt and Oxidative Stress Tolerance显示文摘Sphingolipids, including sphingosine-1-phosphate (S1P), have been shown to function as signaling mediators to regulate diverse aspects of plant growth, development, and stress response. In this study, we performed functional analysis of a rice (Oryza sativa) S1P lyase gene OsSPL1 in transgenic tobacco plants and explored its possible involvement in abiotic stress response. Overexpression of OsSPL1 in transgenic tobacco resulted in enhanced sensitivity to exogenous abscisic acid (ABA), and decreased tolerance to salt and oxidative stress, when compared with the wild type. Furthermore, the expression levels of some selected stress-related genes in OsSPL1-overexpressing plants were reduced after application of salt or oxidative stress, indicating that the altered responsiveness of stress-related genes may be responsible for the reduced tolerance in OsSPL1-overexpressing tobacco plants under salt and oxidative stress. Our results suggest that rice OsSPL1 plays an important role in abiotic stress responses. | Huijuan Zhang Jing Zhai Jibo Mo Dayong Li Fengming Song | 2012 | Journal of Integrative Plant Biology2012，54，9： | 5 |
| 2 | Model-based approach for available bandwidth prediction in multi-hop wireless networks显示文摘We present a complete and practical analytical model for the IEEE 802.11-based multi-hop wireless networks.The features of our model are that it first takes into account the realistic problems both from the physical and MAC (Media Access Control) layers in multi-hop wireless networks,including packet collisions,neighboring interference,hidden node problems,capture effects,non-ideal channels,non-saturated situations and multi-rate sending scenarios,which makes the analytical results more accurate.Second,it relates the network parameters to the bandwidth requirements of flows and thus is capable of directly analyzing bandwidth-sensitive applications.Third,it provides a 'what-if' analysis,enabling us to predict the performance of the network after a new flow enters.Based on this model,we then present and validate iterative algorithms for end-to-end available bandwidth predictions.With the property of fast convergence and easy realization,these algorithms can give predictive estimates on the change of parameters that will affect the available bandwidth and thus enable us to obtain more accurate available bandwidth information. | ZHAO HaiTao WANG Shah WEI JiBo SONG An LI Ying | 2011 | Science China(Information Sciences)2011，54，9： | 3 |
| 3 | Indoor positioning simulation based on Landmarc system 显示文摘 | Li Xingpeng Hu YongMei Song Jibo | 2008 | The Computer Engineering and Application2008，，27： | 1 |
| 4 | Highly pathogenic coronavirus N protein aggravates inflammation by MASP-2-mediated lectin complement pathway overactivation显示文摘Excessive inflammatory responses contribute to the pathogenesis and lethality of highly pathogenic human coronaviruses,but the underlying mechanism remains unclear.In this study,the N proteins of highly pathogenic human coronaviruses,including severe acute respiratory syndrome coronavirus(SARS-CoV),middle east respiratory syndrome coronavirus(MERS-CoV)and severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),were found to bind MASP-2,a key serine protease in the lectin pathway of complement activation,resulting in excessive complement activation by potentiating MBL-dependent MASP-2 activation,and the deposition of MASP-2,C4b,activated C3 and C5b-9.Aggravated inflammatory lung injury was observed in mice infected with adenovirus expressing the N protein.Complement hyperactivation was also observed in SARS-CoV-2-infected patients.Either blocking the N protein:MASP-2 interaction,MASP-2 depletion or suppressing complement activation can significantly alleviate N protein-induced complement hyperactivation and lung injury in vitro and in vivo.Altogether,these data suggested that complement suppression may represent a novel therapeutic approach for pneumonia induced by these highly pathogenic coronaviruses. | Ting Gao Lin Zhu Hainan Liu Xiaopeng Zhang Tingting Wang Yangbo Fu Hongzhen Li Qincai Dong Yong Hu Zhang Zhang Jing Jin Zijing Liu Weihong Yang Yaoning Liu Yanwen Jin Kaitong Li Yongjiu Xiao Junli Liu Huailong Zhao Yue Liu Ping Li Jibo Song Lu Zhang Yuwei Gao Sisi Kang Shoudeng Chen Qingjun Ma Xiuwu Bian Wei Chen Xuan Liu Qing Mao Cheng Cao | 2022 | Signal Transduction and Targeted Therapy2022，7，10： | 0 |
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