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| 1 | Ciliary defects caused by dysregulation of O-GlcNAc modification are associated with diabetic complications显示文摘Dear Editor Diabetes is a chronic metabolic disease that has become a major epidemic worldwide. High blood glucose is thought to be the primary cause of most devastating long-term complications of diabetes. In addition to strict glycemic control,a number of therapeutics have been used to slow down the progression of diabetic complications. However,a majority of current therapies for most diabetic complications have shown disappointing results in clinical trials.Because these complications arise from a number of pathological processes,targets for early interventions that could lead to effective treatments are largely unknown. | Fan Yu Song Guo Te Li Jie Ran Wei Zhao Dengwen Li Min Liu Xiumin Yan Xiaoyong Yang Xueliang Zhu Jun Zhou | 2019 | Cell Research2019，29，2： | 3 |
| 2 | Dynamic rupture of metal sheet subjected to laser irradiation and tangential subsonic airflow显示文摘To reproduce the premature rupture process of metal sheet subjected to laser irradiation with subsonic airflow,which is an interesting phenomenon observed in the experiments given by Lawrence Livermore National Laboratory,a coupled numerical model considering the interaction and evolution of metal elastoplastic deformation and aerodynamic pressure profile is presented.With the thermal elastoplastic constitutive relationship and failure criterion,the simulated failure modes and dynamic rupture process are basically consistent with the experimental results,indicating plastic flow and multiple fracturing is the main failure mechanism.Compared with the case of non-airflow,subsonic airflow not only accelerates deformation,but also turns the bugle deformation,plastic strain and rupture mode into asymmetric. | Xiaodong Xing Te Ma Ruixing Wang Chenyu Cao Hongwei Song Chenguang Huang | 2018 | Theoretical & Applied Mechanics Letters2018，8，4： | 2 |
| 3 | Single amino acid substitution of VP1 N17D or VP2 H145Y confers acid-resistant phenotype of type Asia1 foot-and-mouth disease virus显示文摘Infection by foot-and-mouth disease virus(FMDV) is triggered by the acidic pH in endosomes after virus uptake by receptor-mediated endocytosis. However, dissociation of the FMDV 146S particle in mildly acidic conditions renders inactivated foot-and-mouth disease(FMD) vaccines much less effective. Type Asia1 FMDV mutants with increased resistance to acid inactivation were selected to study the molecular basis of viral resistance to acid-induced disassembly and improve the acid stability of FMDV. Sequencing of capsid-coding regions revealed four amino acid replacements(VP1 N17D, VP2 H145Y, VP2 G192D, and VP3 K153E) in the viral population of the acid-selected 10th passage. We performed single or combined mutagenesis using a reverse genetic system, and our results provide direct experimental evidence that VP2 H145Y or VP1 N17D substitution confers an acid-resistant phenotype to type Asia1 FMDV. | Haiwei Wang Shanshan Song Jianxiong Zeng Guohui Zhou Decheng Yang Te Liang Li Yu | 2014 | Virologica Sinica2014，29，2： | 2 |
| 4 | Visualization and simulation of steel metallurgy processes显示文摘Steel production involves the transfer and transformation of material and energy at different levels, structures, and scales, and this process incurs substantial information in the material and energy dimensions. Given the black-box feature of iron and steel production processes, process visualization plays an important role and inevitably benefits parameter correction, technical support decision-making, personnel training, and other aspects of the steel metallurgy industry. The technological characteristics of the entire process in the steel industry were analyzed in this study, a visualization technology route based on virtual reality(VR) was built, and the important components of visual simulation system for steel industry and the important technical points needed to realize the system were proposed. On the foundation, a visual simulation model for the process scheduling of the iron and steel enterprise raw materials' field, slab, and hot rolling processes was built, and a visualization simulation platform of the iron and steel metallurgy plant-wide process, including ironmaking, steelmaking, hot rolling, and cold rolling, was developed. Lastly, the effectiveness of platform was illustrated by practical application. | Te Xu Guang Song Yang Yang Pei-xin Ge Li-xin Tang | 2021 | International Journal of Minerals,Metallurgy and Materials2021，28，8： | 1 |
| 5 | Smad4/DPC4 and Smad3 mediate TGF-β1 signaling through direct binding to a novel TGF-responsive element in the human plasminogen activator inhibitor-1 promoter显示文摘 | Song C Siok TE Gelehrter TD | 1998 | J Biol Chem1998，273，29： | 1 |
| 6 | Cellular localization of gelatinases and tissue inhibitors of metalloproteinases during follicular growth, ovulation, and early luteal formation in the rat显示文摘 | Curry TE Jr Song L Wheeler SE | 2001 | Biol Reprod2001，65，3： | 1 |
| 7 | Complement in inflamma-torytissue damage and disease显示文摘 | Mollnes TE Song WC Lambris JD | 2002 | Trends Immunol2002，23，2： | 1 |
| 8 | Stanniocalcin 1 is a luminal epithelial marker for implantation in pigs regulated by progesterone and estradiol显示文摘 | Song G Dunlap KA Kim J Bailey DW Spencer TE Burghardt RC Wagner GF Johnson GA Bazer FW | | 0，，02： | 1 |
| 9 | Cathepsins in the ovine uterus:regulation by pregnancy,progesterone,and interferon tau显示文摘 | Song G Spencer TE Bazer FW | | 0，，11： | 1 |
| 10 | Radiation and anthracy- cline-induced cardiac toxicity and the influence of ErbB2 blocking agents显示文摘 | Seemann I te Poele JA Song JY | 2013 | Breast Cancer Res Treat2013，141，3： | 1 |
| 11 | Stanniocalcin (STC) in the endometrial glands of the ovine uterus:regulation by progesterone and placental hormones显示文摘 | Song G Bazer FW Wagner GF Spencer TE | | 0，，05： | 1 |
| 12 | Progesterone and interferon-tau regulate cystatin C in the endometrium显示文摘 | Song G Spencer TE Bazer FW | | 0，，07： | 1 |
| 13 | Gastrin-releasing peptide (GRP) in the ovine uterus:regulation by interferon tau and progesterone显示文摘 | Song G Satteffield MC Kim J Bazer FW Spencer TE | | 0，，02： | 1 |
| 14 | Cellular localization of gelatinases and tissue inhibitors of metalloproeinases during follicular growth,ovulation,and early luteal formation in the rat显示文摘 | Curry TE Jr Song L Wheeler SE | 2001 | Biol Reprod2001，65，3： | 1 |
| 15 | Treatment of recurrent eosinophilic granuloma with systemic therapy显示文摘 | Song A Johnson TE Dubovy SR | 2003 | Ophthal Plast Reconstr Surg2003，19，2： | 1 |
| 16 | Complement in inflammatory tissue damage and disease显示文摘 | Song WC Lambris JD | 2002 | Trends Immunol2002，23，： | 1 |
| 17 | Properties of low-formaldehyde-emission particleboard made from recycled wood-waste chips sprayed with PMDI/PF resin显示文摘 | SONG Y W TE H Y LIT L | 2007 | Building and Environment2007，42，： | 1 |
| 18 | Complement in inflammatory tissue damage and disease 显示文摘 | Song WC Lambris JD | 2002 | Trends Immunol2002，23，2： | 1 |
| 19 | Allelic dimorphism in the merozoite surface protein-3alpha in Korean isolates of Plasmodium vivax显示文摘 | Han ET Song TE Park JH | 2004 | Am J Trop Med Hyg2004，71，6： | 1 |
| 20 | Essential Oil from Inula britannica Extraction with SF-CO_2 and Its Antifungal Activity显示文摘The aim of this study was to determine the extraction technique of supercritical fluid carbon dioxide(SF-CO 2) for the essential oil from Inula britannica flowers and its antifungal activities against plant pathogenic fungi for its potential application as botanical fungicide.The effects of factors,including extraction temperature,extraction pressure,SF-CO 2 flow rate,flower powder size,and time on the essential oil yield were studied using the single factor experiment.An orthogonal experiment was conducted to determine the best operating conditions for the maximum extraction oil yield.Adopting the optimum conditions,the maximum yield reached 10.01% at 40°C temperature,30 MPa pressure,60 mesh flower powder size,20 L h-1SF-CO 2 flow rate,and 90 min extraction time.The antifungal activities of I.britannica essential oil using the SF-CO 2 against the most important plant pathogenic fungi were also examined through in vitro and in vivo tests.Sixteen plant pathogenic fungi were inhibited to varying degrees at 1 mg mL-1concentration of the essential oil.The mycelial growth of Gaeumannomyces graminis var.tritici was completely inhibited.The radial growths of Phytophthora capsici and Fusarium monilifome were also inhibited by 83.76 and 64.69%,respectively.In addition,the essential oil can inhibit the spore germination of Fusarium oxysporum f.sp.vasinfectum,Phytophthora capsici,Colletotrichum orbiculare,and Pyricularia grisea,and the corresponding inhibition rates were 98.26,96.54,87.89,and 87.35% respectively.The present study has demonstrated that the essential oil of I.britannica flowers extracted through the SF-CO 2 technique is one potential and promising antifungal agent that can be used as botanical fungicide to protect crops. | ZHAO Te GAO Fei ZHOU Lin SONG Tian-you | 2013 | Journal of Integrative Agriculture2013，12，10： | 1 |
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