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| 1 | Upregulation of vimentin and aberrant expression of E-cadherin /beta-catenin complex in oral squamous cell carcinomas:correlation with the clinicopathological features and patient outcome显示文摘Oral squamous cell carcinoma is a challenging oncology problem.A reliable biomarker for metastasis or high-risk prognosis in oral cancer patients remains undefined.Using quantitative immunohistochemistry,we examined the expression of vimentin,E-cadherin,and beta-catenin in 83 oral squamous cell carcinoma patients,and the relationships between the expression of these markers and specific clinicopathological features were analysed.The high expression of vimentin was observed in 23 of 43(53%) tumours from patients who eventually developed a recurrent tumour and was associated with recurrence and death(P < 0.001 and < 0.001,respectively).The decreased expression of E-cadherin was observed in 36 of 43(84%) tumours from patients who eventually developed a recurrent tumour and was also associated with recurrence and death(P < 0.001 and < 0.001,respectively).Although no correlation between beta-catenin expression in whole-tumour sections and clinicopathological features was observed,decreased beta-catenin expression at the tumour invasive front was closely associated with recurrence and death(P=0.002 and 0.002,respectively).The expression of vimentin and that of E-cadherin were associated with survival and were independent prognostic factors in univariate and multivariate analyses.Our data show that the overexpression of vimentin was closely associated with recurrence and death in oral squamous cell carcinoma patients.The combination of the upregulation of vimentin and aberrant expression of E-cadherin/beta-catenin complexes at the tumour invasive front may provide a useful prognostic marker in oral squamous cell carcinoma. | Liu,LK Jiang,XY Zhou,XX Wang,DM Song,XL Jiang,HB Nanjing Med Univ,Coll Stomatol,Dept Oral Pathol,Nanjing 210029,Jiangsu,Peoples R China Nanjing Med Univ,Inst Stomatol,Dept Oral Pathol,Nanjing 210029,Jiangsu,Peoples R China Nanjing Med Univ,Coll Stomatol,Dept Oral & Maxillofacial Surg,Nanjing 210029,Jiangsu,Peoples R China | 2010 | 南京医科大学学报(自然科学版)2010，30，5： | 25 |
| 2 | Vasculogenic mimicry is a prognostic factor for postoperative survival in patients with glioblastoma显示文摘A previous report has confirmed the existence and clinical significance of vasculogenic mimicry(VM)in glioma.However,its conclusions about the negative clinical significance of VM in glioblastoma are based on a small group of patients and,thus,might be unconvincing.The aim of the present study was to reevaluate the clinical significance of VM in glioblastoma.Patients were classified as VM-positive or | Wang SY Ke YQ Lu GH Song ZH Yu L Xiao S Sun XL Jiang XD Yang ZL Hu CC | 2013 | 中国神经肿瘤杂志2013，11，3： | 22 |
| 3 | Interleukin-6 alters the cellular responsiveness to clopidogrel, irinotecan, and Oseltamivir by suppressing the expression of Carboxylesterases HCE1 and HCE2显示文摘 | Yang,j shi,D Yang,DF Song,XL Yan,BF | 2007 | 南京医科大学学报(自然科学版)2007，27，11： | 9 |
| 4 | Byakangelicin induces cytochrome P450 3A4 expression via transactivation of pregnane X receptors in human hepatocytes显示文摘 | Yang, JA Luan, XF Gui, HY Yan, P Yang, DF Song, XL Liu, W Hu, G Yah, BF | 2011 | 南京医科大学学报(自然科学版)2011，31，4： | 8 |
| 5 | Autophagy in hypoxia protects cancer cells against apoptosis induced by nutrient deprivation through a Beclin 1-depentent way in hepatocellular carcinoma显示文摘 | Song Jr Guo XL Xie XQ | 2011 | J Cell Biochem2011，112，11： | 1 |
| 6 | ISSR variation within and among natural Brassica juncea populations: implication for herbicide resistance evolution 显示文摘 | Huangfu CH Song XL Qiang S | 2009 | Genet Res Crop Evol2009，56，7： | 1 |
| 7 | Morphological disparities in the epidermal and anatomical features of the leaf among wild Brassica juncea populations 显示文摘 | Huangfu CH Song XL Qiang S | 2009 | Weed Biol Manage2009，9，3： | 1 |
| 8 | Phytoplankton distributions and their relationship with the environment in the Changjiang Estuary,China显示文摘 | GAO XL SONG JM | 2005 | Marine Pollution Bulletin2005，50，： | 1 |
| 9 | Transcriptome of small regulatory RNAs in the development of the zoonotic parasite Trichinella spiralis 显示文摘 | Liu XL Song YX Lu HJ | 2011 | PLoS One2011，6，26： | 1 |
| 10 | HI44a, an anti-CD44 monoclonal antibody, induces differentiation and apoptosis of human acute myeloid leukemia cells 显示文摘 | Song GL Liao XL Han ZC | 2004 | Leuk Res2004，28，10： | 1 |
| 11 | Proton Magnetic Resonance Spectroscopy and Intraoperative MRI Navigation for Frameless Biopsy显示文摘 | Song Z J Chen XL Xu BN | 2012 | J Neurolo Sci-Turkish2012，29，： | 1 |
| 12 | Ecological stoichiometry of carbon,nitrogen,and phosphorus in estuarine wetland soils:influencesof vegetation coverage,plant communities,geomorphology,and seawall 显示文摘 | ZHANG ZS SONG XL LU XG | 2013 | Journal of Soils and Sediments2013，13，6： | 1 |
| 13 | New design approaches to ultra-clean diesel fuels by deep desulfurization and deep dearomatization显示文摘 | Song CS Ma XL | | 0，，： | 1 |
| 14 | Draft genome of the kiwifruit Actinidia chinensis 显示文摘 | Huang SX Ding J Deng DJ Tang W Sun HH Liu DY Zhang L Niu XL Zhang X Meng M Yu JD Liu J Han Y Shi W Zhang DF Cao SQ Wei ZJ Cui YL Xia YH Zeng HP Bao K Lin L Min Y Zhang H Miao M Tang XF Zhu YZ Sui Y Li GW Sun HJ Yue JY Sun JQ Liu FF Zhou LQ Lei L Zheng XQ Liu M Huang L Song J Xu CH Li JW Ye KY Zhong SL Lu BR He GH Xiao FM Wang HL Zheng HK Fei ZJ Liu YS | 2013 | Nat Commun2013，4，： | 1 |
| 15 | Overexpression of adenylate cyclase-associated protein1 is associated with metastasis of lung cancer显示文摘 | TAN M SONG XL ZHANG GL | 2013 | Oncol Reports2013，30，4： | 1 |
| 16 | Clinical observation of concurrent radiotherapy and chemotherapy in the treatment of advanced esophageal cancer with TCF 显示文摘 | Li XL Xing YM Song X | 2008 | Chin J Radiat Oncol2008，17，5： | 1 |
| 17 | Extra- cellular membrane-proximal domain of HAbI8G/CD147 binds to metal ion-dependent adhesion site ( MIDAS ) motif of integrin betal to modulate malignant properties of hepa- toma cells显示文摘 | LI Y WU J SONG F TANG J WANG S J YU XL | 2012 | J Blot Chem2012，287，7： | 1 |
| 18 | A comparison of endoscopic sub- mucosal dissection(ESD) and radical surgery for early gas- tric cancer:a retrospective study 显示文摘 | Song W Qiao XL Gao XZ | 2015 | World J Surg Oncol2015，13，： | 1 |
| 19 | Calcified pericardial cyst-A case report and the roentgenologic and pathologic differentiation from other calcified mediastinal cysts显示文摘 | Zhao F Wang C Song G XL | 1984 | Thorac Cardiovasc Surg1984，32，3： | 1 |
| 20 | The Calcium-sensing receptoraffects fat accumulation via effects on antilipolyticpathways in adipose tissue of rats fed low-calciumdiets显示文摘 | He YH Song Y Liao XL | 2011 | J Nutr2011，141，： | 1 |
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