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| 1 | Deep-learning classifier with ultrawide-field fundus ophthalmoscopy for detecting branch retinal vein occlusion显示文摘AIM: To investigate and compare the efficacy of two machine-learning technologies with deep-learning(DL) and support vector machine(SVM) for the detection of branch retinal vein occlusion(BRVO) using ultrawide-field fundus images. METHODS: This study included 237 images from 236 patients with BRVO with a mean±standard deviation of age 66.3±10.6 y and 229 images from 176 non-BRVO healthy subjects with a mean age of 64.9±9.4 y. Training was conducted using a deep convolutional neural network using ultrawide-field fundus images to construct the DL model. The sensitivity, specificity, positive predictive value(PPV), negative predictive value(NPV) and area under the curve(AUC) were calculated to compare the diagnostic abilities of the DL and SVM models. RESULTS: For the DL model, the sensitivity, specificity, PPV, NPV and AUC for diagnosing BRVO was 94.0%(95%CI: 93.8%-98.8%), 97.0%(95%CI: 89.7%-96.4%), 96.5%(95%CI: 94.3%-98.7%), 93.2%(95%CI: 90.5%-96.0%) and 0.976(95%CI: 0.960-0.993), respectively. In contrast, for the SVM model, these values were 80.5%(95%CI: 77.8%-87.9%), 84.3%(95%CI: 75.8%-86.1%), 83.5%(95%CI: 78.4%-88.6%), 75.2%(95%CI: 72.1%-78.3%) and 0.857(95%CI: 0.811-0.903), respectively. The DL model outperformed the SVM model in all the aforementioned parameters(P<0.001). CONCLUSION: These results indicate that the combination of the DL model and ultrawide-field fundus ophthalmoscopy may distinguish between healthy and BRVO eyes with a high level of accuracy. The proposed combination may be used for automatically diagnosing BRVO in patients residing in remote areas lacking access to an ophthalmic medical center. | Daisuke Nagasato Hitoshi Tabuchi Hideharu Ohsugi Hiroki Masumoto Hiroki Enno Naofumi Ishitobi Tomoaki Sonobe Masahiro Kameoka Masanori Niki Yoshinori Mitamura | 2019 | International Journal of Ophthalmology(English edition)2019，12，1： | 16 |
| 2 | The incidence of coronary artery abnormalitiy in incomplete Kawasaki disease显示文摘 | Sonobe T Aso S Imada Y | 2003 | Pediatr Res2003，53，1： | 1 |
| 3 | Prevalence of coronary artery abnormality in incomplete Kawasaki disease 显示文摘 | Sonobe T Kiyosawa N Tsuchiya K | 2007 | Pediatrics International2007，49，4： | 1 |
| 4 | Revision of diagnostic guide- lines for Kawasaki disease显示文摘 | Ayusawa M Sonobe T Uemura S | 2005 | Pediatr Int2005，47，2： | 1 |
| 5 | Revision of diagnostic guidelines for Kawasaki disease显示文摘 | Ayusawa M Sonobe T Uemura S | 2005 | Pediatr Int2005，47，2： | 1 |
| 6 | Source-related effects of wastewater on transcription factor(AhR,CAR and PXR)-mediated induction of gene expression in cultured rat hepatocytes and their association with the prevalence of antimicrobial-resistant Escherichia coli显示文摘 | Guruge KS Yamanaka N Sonobe M | 2015 | PLoS One2015，10，01： | 1 |
| 7 | Prevalence of coronary artery abnormality in incomplete Kawasaki disease显示文摘 | Sonobe T Kiyosawa N T suchiya K | | 0，，04： | 1 |
| 8 | Possible synergic effect of angiotensin-I converting enzyme gene Insertion/Deletion polymorphism and angiotensin-II type-1 receptor 1166A/C gene polymorphism on ischemic heart disease in patients with Kawasaki disease显示文摘 | Fukazawa R Sonobe T Hamamoto K | 2004 | Pediatr Res2004，56，4： | 1 |
| 9 | The incidence of coronary artery abnormalities in incomplete Kawasaki disease 显示文摘 | Sonobe T Aso S Imada Y | 2003 | Pediatr Res2003，53，： | 1 |
| 10 | A novel classification of MUC1 expression is correlated with tumor differentiation and post- operative prognosis in non - small cell lung cancer 显示文摘 | Nagai S Takenaka K Sonobe M | 2006 | J Thorac Oncol2006，1，1： | 1 |
| 11 | Revision of diagnostic gaiidelines for Kawasaki disease (the 5th revised edition) 显示文摘 | Ayusawa M Sonobe T Uemura S | 2005 | Pediatr Int2005，47，2： | 1 |
| 12 | Revision of diagnostic guidelines for Kawasaki disease显示文摘 | Ayusawa M Sonobe TS | 2005 | Pediatr hit2005，47，2： | 1 |
| 13 | New olefin polymerization catalyst systems comprised of bis(phenoxy-imine) titanium complexes and MgCl2-based activators显示文摘 | Nakayama Y Bando H Sonobe Y | 2003 | Journal of Catalysis2003，，： | 1 |
| 14 | Revision of diagnostic guidelines for Kawasaki disease (the 5th revised edition ) 显示文摘 | Ayusawa M Sonobe T Uemura S | 2005 | Pediatr Int2005，47，2： | 1 |
| 15 | Time Path in Innovation,Imitation,and Growth:the case of the motorcycle industry in postwar Japan显示文摘 | Yamamura Eiji Tetsushi Sonobe and Keijiro Otsuka | 2005 | Journal of Evolutionary2005，，15： | 1 |
| 16 | High frequency of apoptosis in infantile capillary haemangioma 显示文摘 | lwata J Sonobe H Furihata M | 1996 | Pathol1996，179，4： | 1 |
| 17 | Prevalence of coronary artery abnormality jn incomplete Kawasaki disease显示文摘 | Sonobe T Kiyosawa N Tsuchiya K | 2007 | Pediatr Int2007，49，4： | 1 |
| 18 | Mutations in Keapl are a potential prognostic factor in resected non-small cell lung cancer显示文摘 | Takahashi T Sonobe M Menju T etal | 2010 | J Surg Oncol2010，101，6： | 1 |
| 19 | Kinetic analyses of biomass pyrolysis using the distributed activator energy model显示文摘 | Sonobe T Worasuwannarak N | | 0，，03： | 1 |
| 20 | Revision nf diagnostic guidelines for Kawasaki disease (the 5th revised edition) 显示文摘 | Ayusawa M Sonobe T Uemura S | 2005 | Pediatr Int2005，47，2： | 1 |
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