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| 1 | Systematic mechanism-orientated approach to chronic pancreatitis pain显示文摘Pain in chronic pancreatitis(CP) shows similarities with other visceral pain syndromes(i.e.,inflammatory bowel disease and esophagitis),which should thus be managed in a similar fashion.Typical causes of CP pain include increased intrapancreatic pressure,pancreatic inflammation and pancreatic/extrapancreatic complications.Unfortunately,CP pain continues to be a major clinical challenge.It is recognized that ongoing pain may induce altered central pain processing,e.g.,central sensitization or pro-nociceptive pain modulation.When this is present conventional pain treatment targeting the nociceptive focus,e.g.,opioid analgesia or surgical/endoscopic intervention,often fails even if technically successful.If central nervous system pain processing is altered,specific treatment targeting these changes should be instituted(e.g.,gabapentinoids,ketamine or tricyclic antidepressants).Suitable tools are now available to make altered central processing visible,including quantitative sensory testing,electroencephalograpy and(functional) magnetic resonance imaging.These techniques are potentially clinically useful diagnostic tools to analyze central pain processing and thus define optimum management approaches for pain in CP and other visceral pain syndromes.The present review proposes a systematic mechanism-orientated approach to pain management in CP based on a holistic view of the mechanisms involved.Future research should address the circumstances under which central nervous system pain processing changes in CP,and how this is influenced by ongoing nociceptive input and therapies.Thus we hope to predict which patients are at risk for developing chronic pain or not responding to therapy,leading to improved treatment of chronic pain in CP and other visceral pain disorders. | Stefan AW Bouwense Marjan de Vries Luuk TW Schreuder Soren S Olesen Jens B Frokjær Asbjorn M Drewes Harry van Goor Oliver HG Wilder-Smith | 2015 | World Journal of Gastroenterology2015，21，1： | 6 |
| 2 | Identification of prokaryotic and Eukaryotic signal peptides and prediction of their cleavage sites 显示文摘 | Hennik N Jacob E Soren B | 1997 | Protein Engineer1997，10，1： | 1 |
| 3 | Public Policy for Venture Capital 显示文摘 | CHRISTIAN K SOREN B N | 2001 | International Tax and Public Finance2001，8，4： | 1 |
| 4 | Sensori-neural hearing loss after radiotherapy for nasopharyngeal carcinoma:individualized risk estimation显示文摘 | Henriette B Honore Soren M | 2002 | Radiotherapy and Oncology2002，65，1： | 1 |
| 5 | Formation and Movement of 14C-atrazine Degradation Products in a Clay Loam Soil in the Field显示文摘 | Soren B A Koskinen W C Buhler D D | 1994 | Weesd Sci1994，2，： | 1 |
| 6 | Mapping the antigenic structure of porcine parvovirus at the level of peptides显示文摘 | Soren K Jan L Anette B | 1998 | J Virus Res1998，53，： | 1 |
| 7 | Spironolactone induces apoptosis and inhibits NF-κB independent of the mineralocorticoid receptor 显示文摘 | Soren U Salling S Anders W Niels O Klaus B | 2006 | Apoptosis2006，11，12： | 1 |
| 8 | Optimisation of a wet FGD pilot plant using fine limestone and organic acids显示文摘 | Frandsen Jan B W Kiil Soren | 2001 | Chemical Engineering Science2001，56，10： | 1 |
| 9 | Investigation of parameters affecting gypsum dewatering properties in a wet flue gas desulphurization pilot plant显示文摘 | Brian B Hansen Soren Kiil | 2012 | Ind Eng Chem Res2012，51，10： | 1 |
| 10 | Sensori-neural hearing loss after radiotherapy for nasopharyngeal carcinoma: individualized risk estimation显示文摘 | Henriette B Honore Soren M | 2002 | Radiotherapy and Oncology2002，65，： | 1 |
| 11 | The Effect of Grass Maturing and Root Decay on N2O Production in Soil显示文摘 | HANNE B SOREN C | 1987 | Plant and soil1987，103，2： | 1 |
| 12 | Entrepreneurial Learning and the Role of Venture Capitalists显示文摘 | TOMAS H SOREN S | 2007 | Venture Capital2007，9，3： | 1 |
| 13 | How common and how large are cost overruns in transport infrastructure projects显示文摘 | Bent F Mette K S H Soren L B | 2003 | Transport Reviews2003，23，1： | 1 |
| 14 | Effect of freezing temperature thawing and cooking rate on water distribution in two perk qualities显示文摘 | M Margit J A Henrik B E Soren | 2006 | Meat Science2006，，72： | 1 |
| 15 | Starch phosphorylation: a new front line in starch research 显示文摘 | Andreas Blennow Soren B Engelsen Tom H Nielsen | 2002 | TRENDS in Plant Science2002，7，10： | 1 |
| 16 | Appearance of acute PRRS-like symptoms in sow herds after vaccination with a modified live PRRS vaccine 显示文摘 | Bother A Strandboygaard B Soren sen K J | 1997 | Vet Rec1997，141，： | 1 |
| 17 | Dose-response effects of lycopene on selected drug-metabolizing and antioxidant enzymes in the rat显示文摘 | Vibeke B Soren T L Bahrain D | 2000 | Cancer Letters2000，154，： | 1 |
| 18 | Development of a novel realtime RT-PCR assay for quantitation of foot-and-mouth disease virus in diverse porcine tissues 显示文摘 | Martin B O Alex I D Soren A | 2001 | Virol Methods2001，92，： | 1 |
| 19 | Information process ing and firm-internal environment contingencies: perform ance impact on global new product development显示文摘 | ELKO K ULRIKE D B SOREN S | 2010 | Crea tivity and Innovation Management2010，19，3： | 1 |
| 20 | Preventing or reducing late side effects ofradiation therapy: radiobiology meets molecular pathology显示文摘 | SOREN M B | 2006 | Nature2006，6，9： | 1 |
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