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| 1 | Prognostic significance of tumor immune microenvironment and immunotherapy:Novel insights and future perspectives in gastric cancer显示文摘Despite a decrease in gastric cancer incidence, the development of novel biologic agents and combined therapeutic strategies, the prognosis of gastric cancer remains poor. Recently, the introduction of modern immunotherapy, especially using immune checkpoint inhibitors, led to an improved prognosis in many cancers. The use of immunotherapy was also associated with manageable adverse event profiles and promising results in the treatment of patients with gastric cancer, especially in heavily pretreated patients. These data have led to an accelerated approval of some checkpoint inhibitors in this setting. Understanding the complex relationship between the host immune microenvironment and tumor and the immune escape phenomenon leading to cancer occurrence and progression will subsequently lead to the identification of prognostic immune markers. Furthermore, this understanding will result in the discovery of both new mechanisms for blocking tumor immunosuppressive signals and pathways to stimulate the local immune response by targeting and modulating different subsets of immune cells. Due to the molecular heterogeneity of gastric cancers associated with differentclinico-biologic parameters, immune markers expression and prognosis, novel immunotherapy algorithms should be personalized and addressed to selected subsets of gastric tumors, which have been proven to elicit the best clinical responses. Future perspectives in the treatment of gastric cancer include tailored dual immunotherapies or a combination of immunotherapy with other targeted agents with synergistic antitumor effects. | Daniela Cornelia Lazǎr Mihaela Flavia Avram Ioan Romosan Mǎrioara Cornianu Sorina Tǎan Adrian Goldis | 2018 | World Journal of Gastroenterology2018，24，32： | 24 |
| 2 | New advances in targeted gastric cancer treatment显示文摘Despite a decrease in incidence over past decades,gastric cancer remains a major global health problem. In the more recent period, survival has shown only minor improvement, despite significant advances in diagnostic techniques, surgical and chemotherapeutic approaches, the development of novel therapeutic agents and treatment by multidisciplinary teams. Because multiple genetic mutations, epigenetic alterations, and aberrant molecular signalling pathways are involved in the development of gastric cancers, recent research has attempted to determine the molecular heterogeneity responsible for the processes of carcinogenesis, spread and metastasis. Currently, some novel agents targeting a part of these dysfunctional molecular signalling pathways have already been integrated into the standard treatment of gastric cancer, whereas others remain in phases of investigation within clinical trials. It is essential to identify the unique molecular patterns of tumours and specific biomarkers to develop treatments targeted to the individual tumour behaviour. This review analyses the global impact of gastric cancer, as well as the role of Helicobacter pylori infection and the efficacy of bacterial eradication in preventing gastric cancer development. Furthermore, the paper discusses the currently available targeted treatments and future directions of research using promising novel classes of molecular agents for advanced tumours. | Daniela Cornelia Lazar Sorina Taban Marioara Cornianu Alexandra Faur Adrian Goldis | 2016 | World Journal of Gastroenterology2016，22，30： | 15 |
| 3 | Electrochemical detection and degradation of ibuprofen from water on multi-walled carbon nanotubes-epoxy composite electrode显示文摘This work describes the electrochemical behaviour of ibuprofen on two types of multi-walled carbon nanotubes based composite electrodes,i.e.,multi-walled carbon nanotubes-epoxy(MWCNT) and silver-modified zeolite-multi-walled carbon nanotubes-epoxy(AgZMWCNT) composites electrodes.The composite electrodes were obtained using two-roll mill procedure.SEM images of surfaces of the composites revealed a homogeneous distribution of the composite components within the epoxy matrix.AgZMWCNT composite electrode exhibited the better electrical conductivity and larger electroactive surface area.The electrochemical determination of ibuprofen(IBP) was achieved using AgZMWCNT by cyclic voltammetry,differential-pulsed voltammetry,square-wave voltammetry and chronoamperometry.The IBP degradation occurred on both composite electrodes under controlled electrolysis at 1.2 and 1.75 V vs.Ag/AgCl,and IBP concentration was determined comparatively by differential-pulsed voltammetry,under optimized conditions using AgZMWCNT electrode and UV-Vis spectrophotometry methods to determine the IBP degradation performance for each electrode.AgZMWCNT electrode exhibited a dual character allowing a double application in IBP degradation process and its control. | Sorina Motoc Adriana Remes Aniela Pop Florica Manea Joop Schoonman | 2013 | Journal of Environmental Sciences2013，25，4： | 2 |
| 4 | Ki-67 expression in gastric cancer显示文摘 | Daniela Lazar Sorina Taban I Sporea | 2010 | Romanian Journal of Morphology and Embryology2010，51，4： | 1 |
| 5 | Reduced platelet aggregation after fluvastatin therapy is associated with atered platelet lipid composition and drug binding to the platelets显示文摘 | OSAMAH H MIRA R SORINA S | 1997 | Br J Clin Pharmacol1997，44，1： | 1 |
| 6 | Water-oil partition profiling of Ionized drug molecules using cyclic voltammetry and a 96-well microfilter plate system显示文摘 | Sorina M Ulmeanu Henrik Jensen Gé raldine Bouchard | 2003 | Pharmaceutical Research2003，20，8： | 1 |
| 7 | Reduced platelet aggregation after fluvastatin therapy is associated with altered platelet lipid concentration and drug binding to the platelets显示文摘 | Osamah H Mira R Sorina S | 1997 | Br J Clin Pharmacol1997，44，： | 1 |
| 8 | Prognostic Significance of EpCAM-Positive Disseminated Tumor Cells in Rectal Cancer Patients With Stage I Disease显示文摘 | Sameer Dhayat Sorina Sorescu Daniel Vallb?hmer Sebastian Kraus Stephan Ernst Baldus Alexander Rehders Feride Kr?pil Andreas Krieg Wolfram Trudo Knoefel Nikolas Hendrik Stoecklein | 2012 | The American Journal of Surgical Pathology2012，，12： | 1 |
| 9 | Reduced platelet aggregation after fluvastatin therapy is associated with altered platelet lipid composition and drug binding to the platelets 显示文摘 | Mira R Sorina S Shlomo K Michael A | 1997 | Br J Clin Pharmacol1997，44，1： | 1 |
| 10 | Rate dependences of the strength of carbon-fiber- reinforced plastics显示文摘 | Suvorova Yu V Sorina T G Gunyaev G M | 1991 | Mechanics of Composite Materials1991，26，4： | 1 |
| 11 | Detection of LSB steganography via sample pair analysis显示文摘 | Sorina Dumitrescu Wu X L Wang Z | 2003 | IEEE Trans on Signal Processing2003，51，7： | 1 |
| 12 | Detection of LSB steganography via sample pair analysis显示文摘 | SORINA D WU X L WANG ZH | 2003 | IEEE Transactions on Signal Processing2003，51，19： | 1 |
| 13 | FEM simulation of the linear friction welding of titanium alloy 显示文摘 | Sorina J Rettenmayr M Schneefeld D | 2010 | Computational Material Science2010，48，4： | 1 |
| 14 | 查看详情显示文摘 | Schimmel G Sorina J Kempf B | | 0，，： | 1 |
| 15 | Energy-Efficient Full Diversity Collaborative Unitary Space-Time Block Code Designs via Unique Factorization of Signals 显示文摘 | DONG Xia ZHANG Jian-kang SORINA DUMITRESCU | 2013 | IEEE Transactions on Information Theory2013，59，3： | 1 |
| 16 | Reduced platelet aggregation after fluvastatin therapy is associated with altered lipid composition and drug binding to the platelets显示文摘 | MIRA R SORINA S | 1997 | Br J Clin Pharmacol1997，44，1： | 1 |
| 17 | Reduced platelet aggregation after fluvastatin therapy is associated with altered platelet lipid composition and drug binding to the platelets 显示文摘 | OSAMAH H MIRA R SORINA S | 1997 | Br J Clin Pharmacol1997，44，： | 1 |
| 18 | Model innovation system for economical development using entrepreneurship educa- tion 显示文摘 | Sorina M Socaciu T Elena R | 2012 | Procedia Economics and Finance2012，，3： | 1 |
| 19 | Reduced platelet aggregation after fluvastatin therapy is associated with altered platelet lipid composition and drug binding to the platelets显示文摘 | Oaamah H Mira R Sorina S | 1997 | Br J Clin Pharmacol1997，44，1： | 1 |
| 20 | Detection of LSB steganography via sample pair analysis显示文摘 | Sorina D Wu X Wang Z | 2003 | IEEE Transactions on Signal Processing2003，51，7： | 1 |
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