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| 1 | Superoxide dismutase prevents development of adenocarcinoma in a rat model of Barrett's esophagus显示文摘AIM: To test whether antioxidant treatment could prevent the progression of Barrett's esophagus to adenocarcinoma.METHODS: In a rat model of gastroduodenoesophageal reflux by esophagojejunal anastomosis with gastric preservation, groups of 6-10 rats were randomized to receive treatment with superoxide dismutase (SOD) or vehicle and followed up for 4 mo. Rat's esophagus was assessed by histological analysis, superoxide anion and peroxinitrite generation, SOD levels and DNA oxidative damage.RESULTS: All rats undergoing esophagojejunostomy developed extensive esophageal mucosal ulceration and inflammation by mo 4. The process was associated with a progressive presence of intestinal metaplasia beyondthe anastomotic area (9% 1st mo and 50% 4th mo) (94% at the anastomotic level) and adenocarcinoma(11% 1st mo and 60% 4th mo). These changes were associated with superoxide anion and peroxinitrite mucosal generation, an early and significant increase of DNA oxidative damage and a significant decrease in SOD levels (P<0.05). Exogenous administration of SOD decreased mucosal superoxide levels, increased mucosal SOD levels and reduced the risk of developing intestinal metaplasia beyond the anastomotic area (odds ratio = 0.326; 95%CI: 0.108-0.981; P = 0.046),and esophageal adenocarcinoma (odds ratio = 0.243;95%CI: 0.073-0.804; P = 0.021).CONCLUSION: Superoxide dismutase prevents the progression of esophagitis to Barrett's esophagus and adenocarcinoma in this rat model of gastrointestinal reflux, supporting a role of antioxidants in the chemoprevention of esophageal adenocarcinoma. | Elena Piazuelo Carmelo Cebrián Alfredo Escartín Pilar Jiménez Fernando Soteras Javier Ortego Angel Lanas | 2005 | World Journal of Gastroenterology2005，11，47： | 5 |
| 2 | p53 protein agg- regation promotes platinum resistance in ovarian cancer显示文摘 | Yang-Hartwieh Y Soteras MG Lin ZP | 2015 | Oncogene2015，34，27： | 1 |
| 3 | Tryptophan fortification of adapted formula increases plasma trypto-phan concentrations to levels not different from those found inbreast-fed infants显示文摘 | FAZZOLARI-NESCI A DOMIANELLO D SOTERA V | 1992 | Journal of Pediatric Gastroenterology & Nutri-tion1992，14，4： | 1 |
| 4 | Equipment of medicalbackpacks in mountain rescue显示文摘 | Elsensohn F Soteras I Resiten 0 | 2011 | High Alt Med Biol2011，12，4： | 1 |
| 5 | Effect of the arbuscular mycor- rhizal fungus Glomus intraradiees on the false root-knot nema- tode Nacobbus aberrans in tomato plants 显示文摘 | Lax P Beeerra AG Soteras F | 2011 | Biol Fertil Soils2011，47，5： | 1 |
| 6 | Phytotherapy as alt- ernative to hormone replacement therapy 显示文摘 | Molla MD Hidalgo - Mora JJ Soteras MG | 2011 | Front Biosci (Schol Ed)2011，3，： | 1 |
| 7 | 5-1mine-1,2,4-thiadi- azoles: first small molecules as substrate competitive inhibitors of glycogen synthase kinase 3显示文摘 | Palomo V Perez DI Perez C Morales-Garcia JA Soteras I Alonso-Gil S | 2012 | J Med Chem2012，55，4： | 1 |
| 8 | Tryptophan fortification of adapted formula increases plasma tryptophan concentrations to levels not different from those found in breast-fed infants 显示文摘 | Fazzolari-Nesci A Domianello D Sotera V | 1992 | Journal of pediatric gastroenterology and nutrition1992，14，4： | 1 |
| 9 | Equipment of medical backpacks in mountain rescue显示文摘 | ELSENSOHN F SOTERAS I RESITEN O | 2011 | High Ah med Biol2011，12，4： | 1 |
| 10 | Accidental hypothermia显示文摘 | Soteras Martinez I Subirats Bayego E Reisten O | | 0，，： | 1 |
| 11 | Polysaccharides from the green alga Ulva rigida improve the antioxidant status and prevent fatty streak lesions in the high cholesterol fed hamster, an animal model of nutritionally-induced atherosclerosis显示文摘 | Marlène Godard Kelly Décordé Emilie Ventura Gisèle Soteras Jean-Claude Baccou Jean-Paul Cristol Jean-Max Rouanet | 2008 | Food Chemistry2008，，1： | 1 |
| 12 | Phytotherapy asalternative to hormone replacement therapy 显示文摘 | MOLLA M D J’MORA J J H SOTERAS M G | 2011 | Front Biosci2011，3，3： | 1 |
| 13 | Nitric oxide and superqxide anion in low-grade esophagitis induced by acid and pepsin in rabbits 显示文摘 | Soteras F Lanas A Fiteni l | 2000 | Dig Dis Sci2000，45，： | 1 |
| 14 | Superoxide anion and nitric oxide in high-grade esophagitis induced by acid and pepsin in rabbits 显示文摘 | Lanas A Soteras F Jimenez P | 2001 | Dig Dis Sci2001，46，12： | 1 |
| 15 | Superoxide Anion and Nitric Oxide in High-Grade Esophagitis Induced by Acid and Pepsin in Rabbits显示文摘 | Angel Lanas Fernando Soteras Pilar Jimenez Isabel Fiteni Elena Piazuelo Yolanda Royo Javier Ortego Pedro I?arrea Francisco Esteva | 2001 | Digestive Diseases and Sciences2001，，12： | 1 |
| 16 | Superxide anion and nitric oxide inhigh - grade esophagitis induced by acid and pepsin in rabbits 显示文摘 | Lanas A Soteras F Jimenez P | 2001 | DigDis Sci2001，46，12： | 1 |
| 17 | Breast tumors: Composition of micmcalcification 显示文摘 | Morera A F Esteve M P Soteras J M | 1988 | Radiology1988，169，： | 1 |
| 18 | p53 protein aggregation promotes platinum resistance in ovarian cancer显示文摘 | Yang-Hartwich Y Soteras MG Lin ZP | 2015 | Oncogene2015，34，27： | 1 |
| 19 | Superoxide anion and ni- tric oxide in high grade esophagitis induced by acid and pepsin in rabbits显示文摘 | Lanas A Soteras F J imenez P | 2001 | Dig Dis Sci2001，46，12： | 1 |
| 20 | Superpxide anion and nitric oxide in high- grade esophagitis induced by acid and pepsin in rabbits显示文摘 | Lanas A Soteras F Jimenez P etal | 2001 | Dig Dis Sci2001，46，12： | 1 |
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