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| 1 | Ultrastructure and histochemistry of rat myocardial capillary endothelial cells in response to diabetes and hypertension显示文摘Insufficient growth and rarefaction of capillaries, followed by endothelial dysfunction may represent one of the mostcritical mechanisms involved in heart damage. In this study we examined histochemical and ultrastructural changes inmyocardial capillary endothelium in two models of heart failure streptozotocin-induced diabetes mellitus (STZ) and NO-deficient hypertension in male Wistar rats. Diabetes was induced by a single i.v. dose of STZ (45 mg/kg) and chronic 9-week stage was analysed. To induce NO-deficient hypertension, animals were treated with inhibitor of NO synthase L-nitroarginine methylester (L-NAME) (40 mg/kg) for 4 weeks. Left ventricular tissue was processed for enzyme cata-lytic histochemistry of capillary alkaline phosphatase (AlPh), dipeptidyl peptidase IV (DPP IV), and endothelial NOsynthase/NADPH-diaphorase (NOS) and for ultrastructural analysis. In diabetic and hypertensive rats, lower/absentAlPh and DPP IV activities were found in focal micro-areas. NOS activity was significantly reduced and persisted onlylocally. Quantitative evaluation demonstrated reduction of reaction product intensity of AlPh, DPP and NOS by 49.50%,74.36%, 20.05% in diabetic and 62.93%, 82.71%, 37.65% in hypertensive rats. Subcellular alterations of endothelialcells were found in heart of both groups suggesting injury of capillary function as well as compensatory processes.Endothelial injury was more significant in diabetic animals, in contrast the adaptation was more evident in hypertensiveones. Concluding: both STZ-induced diabetes- and NO-deficient hypertension-related cardiomyopathy were accompa-nied by similar features of structural remodelling of cardiac capillary network manifested as angiogenesis and angiopathy.The latter was however, predominant and may accelerate disappearance of capillary endothelium contributing to myo-cardial dysfunction. | Ludmila OKRUHLICOVA Narcis TRIBULOVA1 Peter WEISMANN Ruzena SOTNIKOVA | 2005 | Cell Research2005，15，7： | 4 |
| 2 | Mecha- nism regulating invasiveness and growth of endometriosis lesions in rat experimental model and in humans 显示文摘 | Sotnikova N Y Antiferova Y S Posiseeva L V | 2010 | Feritil Steril2010，93，8： | 1 |
| 3 | Mechanismsregulating invasiveness and growth of endometriosis lesions in rat ex-perimental model and in humans显示文摘 | Sotnikova NY Antsiferova YS Posiseeva LV | 2010 | Fertil Steril2010，93，8： | 1 |
| 4 | An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior 显示文摘 | Beaulieu JM Sotnikova TD Marion S | 2005 | Cell2005，122，2： | 1 |
| 5 | Telomerase activity in B and T lymphocytes of patients with systemic lupus erythematosus显示文摘 | Klapper W Moosig F Sotnikova A | 2004 | Ann Rheum Dis2004，63，： | 1 |
| 6 | An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior显示文摘 | Beaulieu J M Sotnikova T D Marion S | 2005 | Cell2005，122，2： | 1 |
| 7 | Optical-fiber-tip temperature control system for fiber-coupled laser modules in medical equipment显示文摘 | S. E. Aleksandrov G. A. Gavrilov G. Yu. Sotnikova A. L. Ter-Martirosyan | 2014 | Semiconductors2014，，1： | 1 |
| 8 | Tryptophan hydroxylase-2 controls brain serotonin synthesis 显示文摘 | Zhang X Beaulieu JM Sotnikova TD | 2004 | Sci- ence2004，305，： | 1 |
| 9 | Noradrenergic control of eortieo-striato-thalamie and mesolimbic cross-structural synehrony 显示文摘 | Dzirasa K Phillips HW Sotnikova TD | 2010 | J Neurosei2010，30，18： | 1 |
| 10 | Changes in theT-helper cytokine profile and in lympho- cyte activation at the systemic and local levels in women with endometriosis 显示文摘 | Antsiferova Y S Sotnikova N Y Posiseeva L V | 2005 | Fertil Steril2005，84，6： | 1 |
| 11 | Nitric oxide-the endothelium-derived relaxing factor and its role in endothelial functions显示文摘 | Bauer V Sotnikova R | 2010 | Gen Physiol Biophys2010，29，4： | 1 |
| 12 | Cytokine network of eutopic and ectopic endometrium in women with adenomyosis显示文摘 | Sotnikova N Antsiferova I Malyshkina A | 2002 | Am J Reprod Immunol2002，47，4： | 1 |
| 13 | An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior显示文摘 | Beaulieu JM Sotnikova TD Marion S | 2005 | Cell2005，122，2： | 1 |
| 14 | Cytokine network of eutopic andectopic endometrium in women withadenomyosis 显示文摘 | Sotnikova N Antsiferova I MalyshkinaA | 2002 | Am J ReprodImmunol2002，47，4： | 1 |
| 15 | Regulation of Akt signaling by D2 and D3 dopamine re- ceptors in viv0显示文摘 | BEAULIEU J M TIROTTA E SOTNIKOVA T D | 2007 | J Neurosci2007，27，4： | 1 |
| 16 | Nitric oxide-the endothelium- derived relaxing factor and its role in endothelial functions显示文摘 | Bauer V Sotnikova R | 2010 | Gen Physiol Biophys2010，29，4： | 1 |
| 17 | Effects of different treat- ments on endothelialfunction in patients with erectile dysfunction and hypogonadism 显示文摘 | Mazo EB Gamidov SI Sotnikova EM | 2008 | Ter Arlda2008，80，12： | 1 |
| 18 | Food reward in the absence of taste receptor signaling显示文摘 | DE ARAUJO IE OLIVEIRA-MAIA AJ SOTNIKOVA TD | 2008 | Euron2008，57，： | 1 |
| 19 | Enhanced rewarding properties of morphine,but not cocaine,in beta(arrestin)-2 knock-out mice显示文摘 | Bohn LM Gainetdinov RR Sotnikova TD | 2003 | J Neurosci2003，23，10： | 1 |
| 20 | Tryptophan hydroxy- lase-2 controls brain serotonin synthesis显示文摘 | Sotnikova TD Zhang X P eaulieu JM | 2004 | Science2004，305，6： | 1 |
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