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| 1 | After Administration of Intravenous Epinephrine for bee Sting-induced Anaphylaxis: Kounis Syndrome or Epinephrine Effect?显示文摘To the Editor: In the very important report published in Chinese Medical Journal,[1] a 50-year-old male patient, stented with a bare metal stent followed by 3 overlapping drug-eluting stents, developed anaphylactic reaction following a bee sting that was treated with intravenous 0.1 mg epinephrine at a 1:100,000 together with intravenous methylprednisolone, chlorpheniramine maleate, and ranitidine.He developed, immediately after, an anterior wall myocardial infarction, and subsequent coronary arteriography revealed total occlusion in the proximal left anterior descending stent and 90% stenosis with tissue growth in the mid-stent.The authors concluded that the acute myocardial infarction occurred due to acute stent thrombosis caused by exogenous epinephrine administration.This report, however, raises important questions related to the cause and pathophysiology of these events. | Nicholas G Kounis George D Soufras Dimitrios Lianas Nicholas Patsouras | 2016 | Chinese Medical Journal2016，，4： | 2 |
| 2 | Emergence, development, and future of cardio-oncology in China: cardiohypersensitivity, cardiotoxicity and the Kounis syndrome显示文摘To the Editor:Cancer and cardiovascular disease constitute the two major causes of death worldwide. Whereas the incidence of cancer increases among adults up to 74 years of age, above this age the cardiovascular disease surpasses cancer as the primary cause of mortality.[1] Currently, chemotherapy, radiation therapy, and surgery are the main modalities for the treatment of cancer. However, chemotherapy can induce cardiovascular worsening, manifesting as acute and chronic symptomatology. Therefore, the verv interesting report published in Chinese Medical Journal[2] concerning a 60-year-old male patient suffering from coronary artery disease and squamous cell carcinoma of the left lung who developed an ST segment elevation myocardial infarction following treatment with afatinib (tyrosine kinase inhibitor) and gemcitabine (antimetabolite pyrimidine antagonist) and cisplatin (platinum based DNA replication inhibitor) and the subsequent discussion raise several important considerations on cardiac toxicity, cardiac hypersensitivity and the Kounis-hypersensitivity acute coronary syndrome. | Nicholas G. Kounis Ioanna Koniari Panagiotis Plotas George D. Soufras Grigorios Tsigkas Periklis Davlouros George Hahalis | 2019 | Chinese Medical Journal2019，，6： | 2 |
| 3 | Acute Myocardial Infarction Induced by Anaphylaxis in China: The Kounis Syndrome显示文摘 | Nicholas G Kounis Ioanna Koniari Emmanouil Chourdakis George D Soufras Grigorios Tsigkas Periklis Davlouros George Hahalis | 2018 | Chinese Medical Journal2018，，19： | 2 |
| 4 | Penicillin allergy in cancer patients manifesting as Kounis syndrome显示文摘 | Soufras GD Ginopoulos PV Papadaki PJ | | 0，，： | 1 |
| 5 | Serum IgE antibody concentra- tions and the risk of Kounis syndrome显示文摘 | Soufras GD Kounis GN Kounis NG | 2013 | Virchows Arch2013，462，6： | 1 |
| 6 | Anaphylactic Shock: Kounis HypCT-sensitivity-Associated syndrome seems to be the primary cause显示文摘 | Kounis NG Soufras GD Hahalis G | 2013 | N AmJ Med Sci2013，5，11： | 1 |
| 7 | Are bioabsorbable and biodegradable polymer scaffolds still safe or Kounis syndrome is still watching for?显示文摘 | Kounis NG Soufras GD Tsigkas G Hahalis G | 2014 | Chinese Medical Journal2014，，23： | 1 |
| 8 | Attention to infliximab advee events:chimeric monnclonal antibodies can induce anti chimeric antibodies that may result in Kounis hypersensitivity as- sociated acute conmary syndrome显示文摘 | Kounis NG Kounis GN Soufras GD | 2014 | Eur Rev Med Pharmacol Sci2014，18，24： | 1 |
| 9 | Adverse cardiac events to monoclonal antibodies used for cancer therapy: The risk of Kounis syndrome显示文摘 | G Kounis N Soufras GD Tsigkas G | 2014 | Oncoimmunology2014，14，27： | 1 |
| 10 | White blood cell counts, leukocyte ratios, and eosinophils as inflammatory markers in patients with coronary artery disease 显示文摘 | Kounis NG Soufras GD Tsigkas G | 2015 | Clin Appl Thromb Hemost2015，21，2： | 1 |
| 11 | Combined etiology of anaphylactic cardiogenic shock:amiodarone,epinephrine,cardioverter defibrillator,left ventricular assist devices and the Kounis syndrome显示文摘 | Kounis NG Soufras GD Davlouros P | 2015 | Ann Card Anaesth2015，18，2： | 1 |
| 12 | Penicillin allergy in cancer patients manifesting as Kounis syndrome显示文摘 | Soufras G D Ginopoulos P V Papadaki P J | | 0，，04： | 1 |
| 13 | Penicillin allergy in cancer patients manifesting as Kounis syndrome显示文摘 | Soufras GD Ginopoulos PV Papadaki PJ | 2005 | Heart Vessels2005，20，： | 1 |
| 14 | White blood cell counts, leukocyte ratios, and eosinopbils as inflammatory markers in patients with coronary artery disease显示文摘 | Kounis NG Soufras GD Tsigkas G | 2015 | Clin Appl Thromb Hemost2015，21，2： | 1 |
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