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| 1 | Expression of 5-Lipoxygenase in human colorectal cancer显示文摘AIM: To evaluate the 5-lipoxygenases (Loxs) expression level in human colorectal cancer specimens in order to determine its clinicopathologic significance in human tumorigenesis. METHODS: The relative quantity of 5-Lox mRNA in paired 91 colorectal tumor and adjacent normal mucosa samples was determined by real time quantitative PCR. Additionally, the expression of 5-Lox and cyclooxygenase (Cox)-2 proteins was also examined using immunohistochemical staining methods. RESULTS: There was a marked increase in 5-Lox mRNA levels in the tumor compared with paired normal mucosa samples (P < 0.0001). Sixty six (72.5%) tumors showed high 5-Lox mRNA levels. The positivity rate of 5-Lox and Cox-2 protein expression was 68.7% and 79.1% respectively. There was a significant association between tumoral 5-Lox mRNA level and tumor size (Rho = 0.392, P = 0.0002), depth or vessel invasion. CONCLUSION: These results suggest that 5-Lox is up-regulated in colorectal cancer and that inhibition of its expression might be valuable in the prevention and treatment of colorectal cancer. | Labile Togba Soumaoro Satoru Iida Hiroyuki Uetake Megumi Ishiguro Yoko Takagi Tetsuro Higuchi Masamichi Yasuno Masayuki Enomoto Kenichi Sugihara | 2006 | World Journal of Gastroenterology2006，12，39： | 3 |
| 2 | 结肠直肠癌中VEGF-C与Cox-2的共表达及与淋巴结转移的关系显示文摘PURPOSE:Several lines of experimental evidence indicated that over-expression of vascular endothelial growth factor-C and cyclooxygenase-2 genes promotes angiogenesis and lymphangiogenesis,both of which are essential for the growth and spreading of tumor cells.This study was designed to evaluate the coexpression of vascular endothelial growth factor-C and cyclooxygenase-2 in human colorectal carcinoma to determine their relationships and correlations with lymph node metastasis and prognosis.METHODS:Tissue samples of primary tumors and metastatic lymph nodes from 150 patients undergoing intentionally curative surgical resections for colorectal adenocarcinoma were immunohistochemically examined for vascular endothelial growth factor-C,cyclooxygenase-2,and CD34 expressions.Then,we analyzed their relationships and correlations with clinicopathologic findings and patients’survival time.RESULTS:The positivity rate of vascular endothelial growth factor-C and cyclooxygenase-2 in the primary tumor was 68 and 72.7 percent,respectively,and in the metastatic lymph nodes was 93.3 and 80 percent,respectively.A significant correlation was found between the expression scores of vascular endothelial growth factor-C and cyclooxygenase-2(P < 0.0001),and both also were correlated to microvessels density and several clinicopathologic parameters,including primary tumor size,lymph node metastasis,lymphatic invasion,and TNM stage.Patients with vascular endothelial growth factor-C-positive and/or cyclooxygenase-2-positive tumors had a significant shorter survival time than those with negative tumors did.However,in a multivariate analysis,only cyclooxygenase-2 expression was recognized as an independent prognostic factor(P = 0.0412;relative risk ratio,3.067;95 percent confidence interval,1.046-8.994).CONCLUSIONS:These data show that in human colorectal carcinoma,vascular endothelial growth factor-C and cyclooxygenase-2 are coexpressed and significantly associated with lymph node metastasis and prognosis. | Soumaoro L.T. Uetake H. Takagi Y. 廖新华 | 2006 | 世界核心医学期刊文摘(胃肠病学分册)2006，2，9： | 2 |
| 3 | Coexpression of VEGF-C and COX-2 in human colorectal cancer and its association with lymph node metastasis 显示文摘 | Soumaoro L T Uetake H Takagi Y | 2006 | Dis Colon Rectum2006，49，3： | 1 |
| 4 | Cyclooxygenase-2 expression:a significant prognostic indicator for patients with colorectal cancer显示文摘 | SOUMAORO L T UETAKE H HIGUCHI T | 2004 | Clin Cancer Res2004，10，24： | 1 |
| 5 | Coexpression of VEGF-C and COX-2 in humacolorectal cancer and its association with lymph nodmetastasis 显示文摘 | Soumaoro L T Uetake H Takagi Y | 2006 | Dis Colon Rec-tum2006，49，3： | 1 |
| 6 | Coexpression of VEGF-C and Cox-2 in human colorectal cancer and its association with lymph node metastasis 显示文摘 | Soumaoro LT Uetake H Takagi Y | 2006 | Dis Colon Rectum2006，49，3： | 1 |
| 7 | Cyclooxygenase-2 expression: a significant prognostic indicator for patients with colorectal cancer显示文摘 | Soumaoro LT Uetake H Higuchi T | 2004 | Clin Cancer Res2004，10，： | 1 |
| 8 | Coexpression of VEGF-C and Cox-2 in human colorectal cancer and its association with lymph node metastases显示文摘 | Soumaoro LT Uetake H Takagi Y | 2006 | Dis Colon Retum2006，49，： | 1 |
| 9 | Cox-2 in human colorectal cancer and its association with lymph node metastasis显示文摘 | Soumaoro LT | 2006 | Dis Colon Rectum2006，49，3： | 1 |
| 10 | Coexpression of VEGF-C and COX-2 in human colorectal cancer and its association with lymph node metastases显示文摘 | Soumaoro LT Uetake H Takagi Y | 2006 | Dis Colon Rectum2006，49，3： | 1 |
| 11 | Cyclooxygenase-2 expression:a significant prognostic indicator for patients with colorectal cancer显示文摘 | Soumaoro LT Uetake H Higuchi T | | 0，，24： | 1 |
| 12 | Coexpression of VEGF C and Cox 2 in human colorectal cancer and its association with lymph node metastasis显示文摘 | Soumaoro LT Uetake H Takagi Y | 2006 | Dis Colon Rectum2006，49，3： | 1 |
| 13 | Coexpression of VEGF- C and COX-2 in human colorectal cancer and its association with lymph node metastasis 显示文摘 | Soumaoro LT Uetake H Takagi Y | 2006 | Discolon Rectum2006，49，： | 1 |
| 14 | Benign schwannoma of the pancreas显示文摘 | Labile Togba Soumaoro Kenichi Teramoto Tohru Kawamura Noriaki Nakamura Takahiro Sanada Kenichi Sugihara Shigeki Arii | 2005 | Journal of Gastrointestinal Surgery2005，，2： | 1 |
| 15 | Coexpression of VEGF-C and Cox-2 in human colorectal cancer and its association with lymph node metastasis显示文摘 | Soumaoro LT Uetake H Takagi Y | 2006 | Dis Colon Rectum2006，49，3： | 1 |
| 16 | Coexpression of VEGF-C and Cox-2 in human colorectal cancer and its association with lymph node metastasis 显示文摘 | Soumaoro LT Uetake H Takagi Y | 2006 | Dis Colon Rectum2006，49，3： | 1 |
| 17 | Cyclooxygenase-2 expression:a significant prognostic indicator for patients with colorectal cancer显示文摘 | Soumaoro LT Uetake H Higuchi T | 2004 | Clin Cancer Res2004，10，24： | 1 |
| 18 | Coexpression of VEGF-C and Cox-2 in human colorectal cancer and its association with lymph node metastasis显示文摘 | Uetake H Takagi Y | 2006 | Dis Colon Rectum2006，49，3： | 1 |
| 19 | Coexpression of VEGF-C and COX-2 in human colorectal cancer and its association with lymph node metastasis显示文摘 | SOUMAORO L T UETAKE H TAKAGI Y | 2006 | Dis Colon Rectum2006，49，3： | 1 |
| 20 | Coexpression of VEGF-C and Cox-2 in human colorectal cancer and its association with lymph node metastasis显示文摘 | Soumaoro LT Uetake H Takagi Y | 2006 | Dis Colon Rectum2006，49，3： | 1 |
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