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| 1 | prevention of renal dysfunction by nutraceuticals prepared from oil rich plant foods显示文摘Objective:To investigate the protective effect of extracts prepared from avocado,walnut,flaxseed and Eruca sativa seeds in a rat model of kidney dysfunction induced by intraperitoneal cisplatin.Methods:Ethanol and petroleum ether extracts mixture was prepared from each plant.Six groups of rats were conducted:control healthy,cisplatin group and four test groups where rats were given daily oral dose of each extract mixture before cisplatin injection.Different biochemical and cytogenetic parameters and kidney histopathology were determined.Acute toxicity was tested for the nutraceuticals.Total phenolic contents,faity acids(FA) and unsaponifiable matter were assessed in the extracts.Results:Walnut ethanol extract showed the highest content of total phenolic.FA analysis revealed that all the studied plants were rich in unsaturated FA.Gas-liquid chromatographic investigation of the unsaponifiable matter showed the presence of campeslerol.stigmaslerol and β—sitosterol in all the studied plants.Cisplatin treatment induced significant increase in plasma urea,creatinine and malondialdehyde along with significant reduction of plasma albumin,total protein,calalase and total antioxidant as well as reduction in creatinine clearance.Histopathological examination proved the induction of kidney dysfunction.Some sorts of chromosomal aberration and spermshape abnormalities were noticed after cisplatin treatment.Administration of extracts mixtures produced improvements in biochemical,histopathological and cytogenetic parameters.Conclusions:Administration of the studied nutraceuticals proved to possess protective role against cisplatin—induced nephrotoxicity,chromosomal aberration and abnormal sperms.All studied uutraceuticals showed complete safety. | Sahar Y.Al-Okbi Doha A.Mohamed Thanaa E.Hamed Reham SH.Esmail Souria M.Donya | 2014 | Asian Pacific Journal of Tropical Biomedicine2014，4，8： | 5 |
| 2 | Synthesis of belite cement clinker of high hydraulic reactivity显示文摘 | Larbi Kacimi Angélique Simon-Masseron Souria Salem Abdelhamid Ghomari Zoubir Derriche | 2009 | Cement and Concrete Research2009，，7： | 1 |
| 3 | Amoxicillin–clavulanic acid induced sperm abnormalities and histopathological changes in mice显示文摘Objective: To explore the genotoxic potential and histopathological changes induced in liver, kidney, testis, brain and heart after using the antibiotic drug amoxicillin/clavulanic acid(4:1).Methods: The study included chromosomal aberration analysis in bone-marrow and mouse spermatocytes, induction of sperm morphological abnormalities and histopathological changes in different body organs. The drug was administrated orally at a dose of81 mg/kg body weight twice daily(Total = 162 mg/kg/day) for various periods of time equivalent to 625 mg/men(twice daily).Results: The results revealed non-significant chromosomal aberrations induced after treatment with amoxicillin/clavulanic acid(AC) in both bone marrow and mouse spermatocytes after 7 and 10 days treatment. On the other hand, statistically significant percentages of sperm morphological abnormalities were recorded. Such percentage reached 8.10 ± 0.55, 9.86 ± 0.63 and 12.12 ± 0.58 at the three time intervals tested(7, 14 and 35 days after the 1 st treatment respectively)(treatment performed for 5 successive days) compared with 2.78 ± 0.48 for the control. The results also revealed histopathological changes in different body organs after AC treatment which increased with the prolongation of the period of therapy. Congestion of central vain, liver hemorrhage and hydropic changes in hepatocytes were noticed in the liver. Degenerative changes were found in kidney glomerulus and tubules while testis showed atrophy of seminiferous tubules, and reduction of spermatogenesis. AC also induced neurotoxicity and altered brain neurotransmitter levels. Hemorrhage in the myocardium, disruption of cardiac muscle fibers and pyknotic nuclei in cardiomyocytes were recorded as side effects of AC in heart tissue.Conclusions: The results concluded that AC treatment induced sperm morphological abnormalities and histopathological changes in different body organs. Clinicians must be aware of such results while describing the drug. | Maha A. Fahmy Ayman A. Farghaly Enayat A. Omara Zeinab M. Hassan Fawzia A.E. Aly Souria M. Donya Aziza A.E. Ibrahim Elsayed M. Bayoumy | 2017 | Asian Pacific Journal of Tropical Biomedicine2017，7，9： | 0 |
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