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| 1 | Spreading depression enhances humanneocortical excitability invitro显示文摘 | Berger M Speckmann EJ Pape HC | 2008 | Cephalalgia2008，28，5： | 1 |
| 2 | Epileptogenic effect of cyclosporine in guinea-pig hippocampal slices 显示文摘 | Gorji A Scheld HH Speckmann EJ | 2002 | Neuroscience2002，115，4： | 1 |
| 3 | Microcutting of living brain slices by a pulsed ultrafine water jet which allows simultaneous electro physiological recordings显示文摘 | Speckmann E J Kohling R | 1998 | Journal of Neuroscience Methods1998，82，3： | 1 |
| 4 | High selenium intake and increased diabetes risk:experimental evidence for interplay between selenium and carbohydrate metabolism显示文摘 | Steinbrenner H Speckmann B Pinto A | 2011 | J Clin Biochem Nutr2011，48，： | 1 |
| 5 | Hyperbaric oxygen in neurosurgery 显示文摘 | Fischer BR Speckmann E J Greiner C | 2009 | Acta Neurochir ( Wien )2009，151，4： | 1 |
| 6 | Familial hemiplegic migraine and spreading depression显示文摘 | Kazemi H Speckmann EJ Gorji A | 2014 | Iran J Child Neurol2014，8，3： | 1 |
| 7 | Selenoprotein P expres?sion is controlled through interaction of the coactivator PGC-l a with FoxOla and hepatocyte nuclear factor 4a transcription fac?tors 显示文摘 | Speckmann B Walter PL Alili L | 2008 | Hepatology2008，48，6： | 1 |
| 8 | New electrochemical method for the determination of the free surface of phosphate layers显示文摘 | Losch A Schultze J W Speckmann H D | 1991 | Applied Surface Science1991，52，12： | 1 |
| 9 | Development and application of an agriculture BUS for data transfer显示文摘 | Hermann H Speckmann Gerhard Johns | 2001 | Comuters and electronics in agricuhure2001，23，3： | 1 |
| 10 | The next-generation sphingosine-1 receptor modulator BAF312(siponimod) improves cortical network functionality in focal autoimmune encephalomyelitis显示文摘Autoimmune diseases of the central nervous system(CNS) like multiple sclerosis(MS) are characterized by inflammation and demyelinated lesions in white and grey matter regions. While inflammation is present at all stages of MS, it is more pronounced in the relapsing forms of the disease, whereas progressive MS(PMS) shows significant neuroaxonal damage and grey and white matter atrophy. Hence, disease-modifying treatments beneficial in patients with relapsing MS have limited success in PMS. BAF312(siponimod) is a novel sphingosine-1-phosphate receptor modulator shown to delay progression in PMS. Besides reducing inflammation by sequestering lymphocytes in lymphoid tissues, BAF312 crosses the blood-brain barrier and binds its receptors on neurons, astrocytes and oligodendrocytes. To evaluate potential direct neuroprotective effects, BAF312 was systemically or locally administered in the CNS of experimental autoimmune encephalomyelitis mice with distinct grey-and white-matter lesions(focal experimental autoimmune encephalomyelitis using an osmotic mini-pump). Ex-vivo flow cytometry revealed that systemic but not local BAF312 administration lowered immune cell infiltration in animals with both grey and white matter lesions. Ex-vivo voltage-sensitive dye imaging of acute brain slices revealed an altered spatio-temporal pattern of activation in the lesioned cortex compared to controls in response to electrical stimulation of incoming white-matter fiber tracts. Here, BAF312 administration showed partial restore of cortical neuronal circuit function. The data suggest that BAF312 exerts a neuroprotective effect after crossing the blood-brain barrier independently of peripheral effects on immune cells. Experiments were carried out in accordance with German and EU animal protection law and approved by local authorities(Landesamt für Natur, Umwelt und Verbraucherschutz Nordrhein-Westfalen;87-51.04.2010.A331) on December 28, 2010. | Petra Hundehege Manuela Cerina Susann Eichler Christian Thomas Alexander M. Herrmann Kerstin Goel Thomas Müntefering Juncal Fernandez-Orth Stefanie Bock Venu Narayanan Thomas Budde Erwin-Josef Speckmann Heinz Wiendl Anna Schubart Tobias Ruck Sven G. Meuth | 2019 | Neural Regeneration Research2019，14，11： | 1 |
| 11 | A portable chamber for long-distance transport of surviving human brain slice preparations 显示文摘 | KOHLING R ALUCKE H SPECKMANN E J | 1996 | Neuroscience Methods1996，67，： | 1 |
| 12 | Built-in diagnostics for monitoring crack growth in aircraft structures 显示文摘 | Ihn J B Chang F K Speckmann H | 2001 | Damage Assessment of Structures2001，2042，： | 1 |
| 13 | Development and application of an agricultural BUS for data transfer显示文摘 | Speckmann H Jahns G | 1999 | Computers and Electronics in Agriculture1999，23，3： | 1 |
| 14 | Antisense expression of polyphenol oxidase genes inhibits enzymatic browning in potato tubers显示文摘 | BACHEM C W B SPECKMANN G J LINDE P C G D | 1994 | Nature Biotechnology1994，1201，： | 1 |
| 15 | Development and application of an agricultural BUS for data transfer 显示文摘 | SPECKMANN H JAHNS G | 1999 | Comput Electron Agric1999，23，3： | 1 |
| 16 | Flow map layout via spiraltrees 显示文摘 | Verbeek K Buchin K Speckmann B | 2011 | IEEE Transactions on Visualization and ComputerGraphics2011，17，25： | 1 |
| 17 | Hyperbaric oxygen in neurosurgery 显示文摘 | Fischer BR Speckmann E J Greiner C | 2009 | Acta Neurochirurgica2009，151，4： | 1 |
| 18 | High selenium in- take and increased diabetes risk:experimental evidence for iuter- play between selcnimn and carbohydrate nmtabolism 显示文摘 | Stcinbrenner H Speckmann B Piouto A | 2011 | J Clin Biocbem Nutr2011，48，1： | 1 |
| 19 | Investigation of oxidation protected C/C heat shield material in different plasma wind tunnels 1 1 Paper IAF-96-I.3.06 presented at the 47th International Astronautical Congress, October 7–11, 1996, Beijing, China.显示文摘 | M. Auweter-Kurtz G. Hilfer H. Habiger K. Yamawaki T. Yoshinaka H.-D. Speckmann | 1996 | Acta Astronautica1996，，2： | 1 |
| 20 | New electro- chemical method for the determination of the free sur- face of phosphate layers显示文摘 | Losch A Schultze J W Speckmann H D | 1991 | Applied Surcace Science1991，52，12： | 1 |
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